October 6, 2022

October 2022 CPOD Faculty Publication Spotlight-Seo Lab

Ekaputri S, Choi EK, Sabelli M, Aring L, Green KJ, Chang J, Bao K, Choi HS, Iwase S, Kim J, Corradini E, Pietrangelo A, Burke MD, Seo YA.  Proc Natl Acad Sci U S A. 2022 Jun 28;119(26) A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages.

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Iron misdistribution underlies various diseases, ranging from anemia to neurodegeneration. We previously reported that a small molecule natural product, hinokitiol, is capable of restoring hemoglobinization in various animal models with missing iron transporters. We now demonstrated that hinokitiol is capable of redistributing iron systemically, which in turn restores iron homeostasis in ferroportin-deficient mice and in primary macrophages derived from patients with ferroportin disease.