Areas of Interest
Dr. Chinnaiyan’s laboratory is focused on using functional genomic, proteomic, metabolomic and bioinformatics approaches to dissect and understand cancer biology as well as discover biomarkers. He and his collaborators have characterized a number of biomarkers of prostate cancer including AMACR, EZH2, hespin and sarcosine. His laboratory identified recurrent gene fusions of TMPRSS2 to ETS family transcription factors in prostate cancer, potentially redefining the molecular basis of prostate cancer as well as other common epithelial cancers. His laboratory developed the popular cancer profiling bioinformatics resource called Oncomine (www.oncomine.org (link is external)).