Arushi Varshney, PhD
Research Investigator
Computational Medicine and Bioinformatics
Department of Computational Medicine & Bioinformatics
100 Washtenaw Ave., 2049 Palmer Commons
Ann Arbor, MI 48109
[email protected]

Available to mentor

Arushi Varshney, PhD
Research Investigator
  • Qualifications
  • Research Overview
  • Links
  • Recent Publications
  • Qualifications
    • Doctor of Philosophy (PhD) in Human Genetics
      University of Michigan, Ann Arbor, MI, 2019
    • Master of Science (MS) in Bioengineering
      Swiss Federal Institute of Technology, Lausanne, 2014
    • Bachelor of Technology (BTech) in Biotechnology
      Indian Institute of Technology Guwahati, Assam, 2012
    Research Overview

    Through my research, I am to better understand how predisposition to complex metabolic diseases such as type 2 diabetes (T2D) is encoded in our DNA. I employ computational and statistical approaches to analyze large high-throughput data sets on the genome, epigenome, and transcriptome in disease-relevant tissues/cells to understand biological mechanisms of gene regulation.

    Links
    • Google Scholar
    • GitHub
    Recent Publications See All Publications
    • Journal Article
      Genetic risk converges on regulatory networks mediating early type 2 diabetes.
      Walker JT, Saunders DC, Rai V, Chen H-H, Orchard P, Dai C, Pettway YD, Hopkirk AL, Reihsmann CV, Tao Y, Fan S, Shrestha S, Varshney A, Petty LE, Wright JJ, Ventresca C, Agarwala S, Aramandla R, Poffenberger G, Jenkins R, Mei S, Hart NJ, Phillips S, Kang H, Greiner DL, Shultz LD, Bottino R, Liu J, Below JE, HPAP Consortium , Parker SCJ, Powers AC, Brissova M. Nature, 2023 Dec; 624 (7992): 621 - 629. DOI:10.1038/s41586-023-06693-2
      PMID: 38049589
    • Preprint
      An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals.
      Zhao Z, D'Oliveira Albanus R, Taylor H, Tang X, Han Y, Orchard P, Varshney A, Zhang T, Manickam N, Erdos M, Narisu N, Taylor L, Saavedra X, Zhong A, Li B, Zhou T, Naji A, Liu C, Collins F, Parker SC, Chen S. 2023 Oct 18; DOI:10.21203/rs.3.rs-3343318/v1
      PMID: 37886586
    • Preprint
      Using a modular massively parallel reporter assay to discover context-specific regulatory grammars in type 2 diabetes
      Tovar A, Kyono Y, Nishino K, Bose M, Varshney A, Parker SCJ, Kitzman J. 2023 bioRxiv, DOI:10.1101/2023.10.08.561391
    • Journal Article
      Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.
      Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, MAGIC Investigators , Diabetes Prevention Program (DPP) Research Group , Udler MS, Leong A, Mercader JM, Florez JC. Diabetologia, 2023 Jul; 66 (7): 1260 - 1272. DOI:10.1007/s00125-023-05922-7
      PMID: 37233759
    • Journal Article
      Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis.
      Tenney AP, Di Gioia SA, Webb BD, Chan W-M, de Boer E, Garnai SJ, Barry BJ, Ray T, Kosicki M, Robson CD, Zhang Z, Collins TE, Gelber A, Pratt BM, Fujiwara Y, Varshney A, Lek M, Warburton PE, Van Ryzin C, Lehky TJ, Zalewski C, King KA, Brewer CC, Thurm A, Snow J, Facio FM, Narisu N, Bonnycastle LL, Swift A, Chines PS, Bell JL, Mohan S, Whitman MC, Staffieri SE, Elder JE, Demer JL, Torres A, Rachid E, Al-Haddad C, Boustany R-M, Mackey DA, Brady AF, Fenollar-Cortés M, Fradin M, Kleefstra T, Padberg GW, Raskin S, Sato MT, Orkin SH, Parker SCJ, Hadlock TA, Vissers LELM, van Bokhoven H, Jabs EW, Collins FS, Pennacchio LA, Manoli I, Engle EC. Nat Genet, 2023 Jul; 55 (7): 1149 - 1163. DOI:10.1038/s41588-023-01424-9
      PMID: 37386251
    • Journal Article
      Loci for insulin processing and secretion provide insight into type 2 diabetes risk.
      Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A, Jackson AU, Ahuja V, Bornstein SR, Corbin LJ, Delgado GE, Dwivedi OP, Fernandes Silva L, Frayling TM, Grallert H, Gustafsson S, Hakaste L, Hammar U, Herder C, Herrmann S, Højlund K, Hughes DA, Kleber ME, Lindgren CM, Liu C-T, Luan J, Malmberg A, Moissl AP, Morris AP, Perakakis N, Peters A, Petrie JR, Roden M, Schwarz PEH, Sharma S, Silveira A, Strawbridge RJ, Tuomi T, Wood AR, Wu P, Zethelius B, Baldassarre D, Eriksson JG, Fall T, Florez JC, Fritsche A, Gigante B, Hamsten A, Kajantie E, Laakso M, Lahti J, Lawlor DA, Lind L, März W, Meigs JB, Sundström J, Timpson NJ, Wagner R, Walker M, Wareham NJ, Watkins H, Barroso I, O'Rahilly S, Grarup N, Parker SC, Boehnke M, Langenberg C, Wheeler E, Mohlke KL. Am J Hum Genet, 2023 Feb 2; 110 (2): 284 - 299. DOI:10.1016/j.ajhg.2023.01.002
      PMID: 36693378
    • Journal Article
      Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.
      DiCorpo D, Gaynor SM, Russell EM, Westerman KE, Raffield LM, Majarian TD, Wu P, Sarnowski C, Highland HM, Jackson A, Hasbani NR, de Vries PS, Brody JA, Hidalgo B, Guo X, Perry JA, O'Connell JR, Lent S, Montasser ME, Cade BE, Jain D, Wang H, D'Oliveira Albanus R, Varshney A, Yanek LR, Lange L, Palmer ND, Almeida M, Peralta JM, Aslibekyan S, Baldridge AS, Bertoni AG, Bielak LF, Chen C-S, Chen Y-DI, Choi WJ, Goodarzi MO, Floyd JS, Irvin MR, Kalyani RR, Kelly TN, Lee S, Liu C-T, Loesch D, Manson JE, Minster RL, Naseri T, Pankow JS, Rasmussen-Torvik LJ, Reiner AP, Reupena MS, Selvin E, Smith JA, Weeks DE, Xu H, Yao J, Zhao W, Parker S, Alonso A, Arnett DK, Blangero J, Boerwinkle E, Correa A, Cupples LA, Curran JE, Duggirala R, He J, Heckbert SR, Kardia SLR, Kim RW, Kooperberg C, Liu S, Mathias RA, McGarvey ST, Mitchell BD, Morrison AC, Peyser PA, Psaty BM, Redline S, Shuldiner AR, Taylor KD, Vasan RS, Viaud-Martinez KA, Florez JC, Wilson JG, Sladek R, Rich SS, Rotter JI, Lin X, Dupuis J, Meigs JB, Wessel J, Manning AK. Commun Biol, 2022 Jul 28; 5 (1): 756 DOI:10.1038/s42003-022-03702-4
      PMID: 35902682
    • Preprint
      Single-cell gene expression and chromatin accessibility profiling of human pancreatic islets at basal and stimulatory conditions nominates mechanisms of type 1 diabetes genetic risk
      Albanus RD, Tang X, Taylor HJ, Manickam N, Erdos M, Narisu N, Han Y, Orchard P, Varshney A, Liu C, Naji A, Consortium H, Collins FS, Chen S, Parker SCJ. bioRxiv, DOI:10.1101/2022.11.12.516291