Research Investigator
Computational Medicine and Bioinformatics
Department of Computational Medicine & Bioinformatics
100 Washtenaw Ave., 2049 Palmer Commons
Ann Arbor, MI 48109
[email protected]
100 Washtenaw Ave., 2049 Palmer Commons
Ann Arbor, MI 48109
Available to mentor
Arushi Varshney, PhD
Research Investigator
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Doctor of Philosophy (PhD) in Human GeneticsUniversity of Michigan, Ann Arbor, MI, 2019
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Master of Science (MS) in BioengineeringSwiss Federal Institute of Technology, Lausanne, 2014
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Bachelor of Technology (BTech) in BiotechnologyIndian Institute of Technology Guwahati, Assam, 2012
Through my research, I am to better understand how predisposition to complex metabolic diseases such as type 2 diabetes (T2D) is encoded in our DNA. I employ computational and statistical approaches to analyze large high-throughput data sets on the genome, epigenome, and transcriptome in disease-relevant tissues/cells to understand biological mechanisms of gene regulation.
Google Scholar GitHub
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Walker JT, Saunders DC, Rai V, Chen H-H, Orchard P, Dai C, Pettway YD, Hopkirk AL, Reihsmann CV, Tao Y, Fan S, Shrestha S, Varshney A, Petty LE, Wright JJ, Ventresca C, Agarwala S, Aramandla R, Poffenberger G, Jenkins R, Mei S, Hart NJ, Phillips S, Kang H, Greiner DL, Shultz LD, Bottino R, Liu J, Below JE, HPAP Consortium , Parker SCJ, Powers AC, Brissova M. Nature, 2023 Dec; 624 (7992): 621 - 629.Journal ArticleGenetic risk converges on regulatory networks mediating early type 2 diabetes.
DOI:10.1038/s41586-023-06693-2 PMID: 38049589 -
Zhao Z, D'Oliveira Albanus R, Taylor H, Tang X, Han Y, Orchard P, Varshney A, Zhang T, Manickam N, Erdos M, Narisu N, Taylor L, Saavedra X, Zhong A, Li B, Zhou T, Naji A, Liu C, Collins F, Parker SC, Chen S. 2023 Oct 18;PreprintAn integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals.
DOI:10.21203/rs.3.rs-3343318/v1 PMID: 37886586 -
Tovar A, Kyono Y, Nishino K, Bose M, Varshney A, Parker SCJ, Kitzman J. 2023 bioRxiv,PreprintUsing a modular massively parallel reporter assay to discover context-specific regulatory grammars in type 2 diabetes
DOI:10.1101/2023.10.08.561391 -
Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, MAGIC Investigators , Diabetes Prevention Program (DPP) Research Group , Udler MS, Leong A, Mercader JM, Florez JC. Diabetologia, 2023 Jul; 66 (7): 1260 - 1272.Journal ArticleGenome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.
DOI:10.1007/s00125-023-05922-7 PMID: 37233759 -
Tenney AP, Di Gioia SA, Webb BD, Chan W-M, de Boer E, Garnai SJ, Barry BJ, Ray T, Kosicki M, Robson CD, Zhang Z, Collins TE, Gelber A, Pratt BM, Fujiwara Y, Varshney A, Lek M, Warburton PE, Van Ryzin C, Lehky TJ, Zalewski C, King KA, Brewer CC, Thurm A, Snow J, Facio FM, Narisu N, Bonnycastle LL, Swift A, Chines PS, Bell JL, Mohan S, Whitman MC, Staffieri SE, Elder JE, Demer JL, Torres A, Rachid E, Al-Haddad C, Boustany R-M, Mackey DA, Brady AF, Fenollar-Cortés M, Fradin M, Kleefstra T, Padberg GW, Raskin S, Sato MT, Orkin SH, Parker SCJ, Hadlock TA, Vissers LELM, van Bokhoven H, Jabs EW, Collins FS, Pennacchio LA, Manoli I, Engle EC. Nat Genet, 2023 Jul; 55 (7): 1149 - 1163.Journal ArticleNoncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis.
DOI:10.1038/s41588-023-01424-9 PMID: 37386251 -
Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A, Jackson AU, Ahuja V, Bornstein SR, Corbin LJ, Delgado GE, Dwivedi OP, Fernandes Silva L, Frayling TM, Grallert H, Gustafsson S, Hakaste L, Hammar U, Herder C, Herrmann S, Højlund K, Hughes DA, Kleber ME, Lindgren CM, Liu C-T, Luan J, Malmberg A, Moissl AP, Morris AP, Perakakis N, Peters A, Petrie JR, Roden M, Schwarz PEH, Sharma S, Silveira A, Strawbridge RJ, Tuomi T, Wood AR, Wu P, Zethelius B, Baldassarre D, Eriksson JG, Fall T, Florez JC, Fritsche A, Gigante B, Hamsten A, Kajantie E, Laakso M, Lahti J, Lawlor DA, Lind L, März W, Meigs JB, Sundström J, Timpson NJ, Wagner R, Walker M, Wareham NJ, Watkins H, Barroso I, O'Rahilly S, Grarup N, Parker SC, Boehnke M, Langenberg C, Wheeler E, Mohlke KL. Am J Hum Genet, 2023 Feb 2; 110 (2): 284 - 299.Journal ArticleLoci for insulin processing and secretion provide insight into type 2 diabetes risk.
DOI:10.1016/j.ajhg.2023.01.002 PMID: 36693378 -
DiCorpo D, Gaynor SM, Russell EM, Westerman KE, Raffield LM, Majarian TD, Wu P, Sarnowski C, Highland HM, Jackson A, Hasbani NR, de Vries PS, Brody JA, Hidalgo B, Guo X, Perry JA, O'Connell JR, Lent S, Montasser ME, Cade BE, Jain D, Wang H, D'Oliveira Albanus R, Varshney A, Yanek LR, Lange L, Palmer ND, Almeida M, Peralta JM, Aslibekyan S, Baldridge AS, Bertoni AG, Bielak LF, Chen C-S, Chen Y-DI, Choi WJ, Goodarzi MO, Floyd JS, Irvin MR, Kalyani RR, Kelly TN, Lee S, Liu C-T, Loesch D, Manson JE, Minster RL, Naseri T, Pankow JS, Rasmussen-Torvik LJ, Reiner AP, Reupena MS, Selvin E, Smith JA, Weeks DE, Xu H, Yao J, Zhao W, Parker S, Alonso A, Arnett DK, Blangero J, Boerwinkle E, Correa A, Cupples LA, Curran JE, Duggirala R, He J, Heckbert SR, Kardia SLR, Kim RW, Kooperberg C, Liu S, Mathias RA, McGarvey ST, Mitchell BD, Morrison AC, Peyser PA, Psaty BM, Redline S, Shuldiner AR, Taylor KD, Vasan RS, Viaud-Martinez KA, Florez JC, Wilson JG, Sladek R, Rich SS, Rotter JI, Lin X, Dupuis J, Meigs JB, Wessel J, Manning AK. Commun Biol, 2022 Jul 28; 5 (1): 756Journal ArticleWhole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.
DOI:10.1038/s42003-022-03702-4 PMID: 35902682 -
Albanus RD, Tang X, Taylor HJ, Manickam N, Erdos M, Narisu N, Han Y, Orchard P, Varshney A, Liu C, Naji A, Consortium H, Collins FS, Chen S, Parker SCJ. bioRxiv,PreprintSingle-cell gene expression and chromatin accessibility profiling of human pancreatic islets at basal and stimulatory conditions nominates mechanisms of type 1 diabetes genetic risk
DOI:10.1101/2022.11.12.516291