BIOINF-528: Structural Bioinformatics

Credits: 3
Category: Advanced Bioinformatics and Computational Biology
Instructor: Prof. Yang Zhang

Offered in Fall
Fridays, 9:00 am - 12:00 noon
Rm. 2036 Palmer Commons Bldg.
Syllabus (PDF)

This course introduces fundamental concepts and methods for structural bioinformatics and the advanced applications. Topics covered include sequence, structure and function databases of DNA and protein molecules, advanced sequence and structure alignment methods, methods of protein folding and protein structure prediction (homologous modeling, threading and ab initio folding), basics of molecular dynamics and Monte Carlo simulation, principle and application of machine learning, and techniques of protein structure determination (X-ray crystallography, NMR and cryo-EM). Emphasis is on the understanding of the concepts taught and the practical utilization, with the objective to help students to use the cutting-edge bioinformatics tools/methods to solve problems in their own research. For this term, top experts are invited to give lectures on mass spectrometry and proteomics (Prof. Philip Andrews), NMR spectroscopy (Prof. Tomek Cierpicki), Cryo-electron microscopy (Prof. Melanie Ohi), and X-ray crystallography (Prof. Mark Saper).