Jun Li, Ph.D.

Jun Li, Ph.D.

Professor of Computational Medicine and Bioinformatics
Associate Chair for Research, Department of Computational Medicine and Bioinformatics
Professor of Human Genetics

Administrative Contact

Amy Koger

Areas of Interest

Genetic and genomic analyses of complex phenotypes, including bipolar disorder, cancer, blood clotting disease, and traits involving animal models and human microbiomes. Our approach emphasizes statistical analysis of genome-scale datasets (e.g, gene expression and genotyping data, results from next-generation sequencing), evolutionary history, bioinformatics, and pattern recognition.

Main Funding Sources

NIH 1R01DK099034: Genotype-Phenotype relationships underlying aerobic capacity and metabolic health (contact PI: Li, MPIs: Burant, Britton)               

NIH 1R01GM118928: High-resolution map of human germline mutation patterns and inference of mutagenic mechanisms (contact PI: Li, MPI: Zoellner)

NIH U01DA043098: Genetics of novelty seeking and propensity for drug abuse in outbred rats (contact PI: Akil, MPI: Li)

NIH 1U24DK112342: Michigan MoTrPAC Chemical Analysis Site (MiCAS) (contact PI: Burant, MPI: Li)

NIH 5P40OD021331: Resource for Rat Genetic Models of Aerobic Capacity (MPI: Britton, Koch, Co-I: Li)

Michigan Institute for Data Science (MIDAS): Michigan Center for Single-Cell Genomic Data Analytics (Co-PI: Li, Gilbert, Co-I: 8 others)

UMHS-PUHSC Joint institute Discovery Grant: Genomic evolution and mutational signature of esophageal cancer in Anyang, China (PI: Li)

Michigan Diabetes Research Ctr. Study Grant: Elucidating the landscape of liver cell heterogeneity in normal and insulin resistant states by single cell RNA sequencing (co-PI: Lin, Li, Kurabayashi)

Cancer Center Research Committee Innovation Grant: Identifying the cellular source of relapse in AML (Co-PI: Malek, Li)

Taubman Institute Grand Challenge Phase I Grants: Individualized Disease Prediction Using a Multi-Dimensional, Time-Resolved “Big Data” Approach (Co-PI: Choi, Tewari, Co-I, Li)

Pritzker Neuropsychiatric Disorders Research Consortium: Genetic and genomic analyses of psychiatric disorders (PI of subcontract: Li)

NIH 1R01HL139672: Genetic and Genomic Analysis of Arterial Dysplasia (PI: Ganesh, Co-I, Li)

NIH R21HD090371: Comprehensive mapping of mouse testis cell types and spermatogenic stages by single-cell RNA sequencing (PI: Hammoud, Co-I, Li)

Positions Available

The Li lab is recruiting talented individuals with background in quantitative analysis or interest in statistical genetics, bioinformatics, or cancer genomics. Positions are open at multiple levels: graduate student, postdoc, research staff, or research-track faculty. Current projects (2016-2020) include: single-cell RNAseq data analysis, methodological and theoretical research in clustering, mutation patterns in the human genome, multi-omics data integration involving metabolomic, proteomic, and transcriptomic data, QTL mapping in rat models of metabolomic traits and emotional traits. Please contact junzli@med.umich.edu.

Published Articles via Michigan Experts or PubMed

Web Sites