Mats Ljungman, Ph.D.

Mats Ljungman, Ph.D.

CCMB Affiliated Faculty
Professor of Radiation Oncology
Professor of Environmental Health Sciences

Areas of Interest

We have developed four techniques based on bromouridine labeling of nascent RNA that allow us to estimate both the rate of transcription (Bru-seq) and the rate of degradation and splicing kinetics (BruChase-seq) of any RNA. In addition, the use of UV light to introduce random transcription-blocking lesions allowing us to map transcription start sites and active enhancer elements genome-wide (BruUV-seq). Finally, BruDRB-seq allows for the assessment of transcription elongation rates genome-wide. We have gotten funding from NIHGR and we participate in the ENCODE consortium to further develop the Bru-seq technologies.

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