Available to mentor
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Center MemberRogel Cancer Center
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Center MemberPrecision Health Initiative
The Sartor laboratory has both methodological and biomedical areas of focus. Their methodological focus is bioinformatics methods and tools for the analysis of genome-wide regulatory and epigenomics data, and for assessing the biological/clinical significance of results. For instance, Dr. Sartor is a member of the Impact of Genomic Variants on Function (IGVF) NIH Consortium, for which she is developing a coupled tensor-matrix completion method to prioritize disease-specific variant-gene target pairs. The Sartor Lab also focuses on multi-omics approaches for biomarker and treatment-target discovery in disease, focusing specifically on Amyotrophic Lateral Sclerosis (ALS) and head and neck squamous cell carcinomas (HNSCC). Dr. Sartor is PI of an R01 studying downstream consequences of HPV integration in HPV-associated HNSCC, and Co-PI of a Transformative R01 linking environmental exposures with multi-omics in ALS. Being formally trained in biostatistics, Dr. Sartor uses machine learning and statistical approaches to make advances in the above areas.
Sartor Lab
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Petroff RL, Dolinoy DC, Wang K, Montrose L, Padmanabhan V, Peterson KE, Ruden DM, Sartor MA, Svoboda LK, Téllez-Rojo MM, Goodrich JM. Environ Int, 2024 Mar 11; 186: 108575Journal ArticleTranslational toxicoepigenetic Meta-Analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead exposure in mouse and human offspring.
DOI:10.1016/j.envint.2024.108575 PMID: 38507935 -
Li S, Xia S, Lawas M, Qin T, Grab B, D'Silva N, Rozek L, Sartor M. Cancer Research, 2024 Mar 22; 84 (6_Supplement): 2280 - 2280.Journal ArticleAbstract 2280: HPV integration identifies emerging oncogenes and carcinogenic mechanisms, potentially indicating tumor recurrences
DOI:10.1158/1538-7445.am2024-2280 -
Garb BF, Li S, Qin T, Lopez E, Soppe S, Patil S, Rozek L, D'Silva N, Sartor M. Cancer Research, 2024 Mar 22; 84 (6_Supplement): 3491 - 3491.Journal ArticleAbstract 3491: Tumor subtype classification of HPV-associated head and neck cancers is central to key clinically relevant variables
DOI:10.1158/1538-7445.am2024-3491 -
Kandarpa M, Robinson D, Wu Y-M, Qin T, Pettit K, Li Q, Luker G, Sartor M, Chinnaiyan A, Talpaz M. Clin Cancer Res, 2024 Feb 22;Journal ArticleBroad next generation integrated sequencing of myelofibrosis identifies disease-specific and age-related genomic alterations.
DOI:10.1158/1078-0432.CCR-23-0372 PMID: 38386293 -
Wang K, Kim N, Bagherian M, Li K, Chou E, Colacino JA, Dolinoy DC, Sartor MA. Environ Sci Technol, 2024 Apr 2; 58 (13): 5889 - 5898.Journal ArticleGene Target Prediction of Environmental Chemicals Using Coupled Matrix-Matrix Completion.
DOI:10.1021/acs.est.4c00458 PMID: 38501580 -
Wang K, Perera BPU, Morgan RK, Sala-Hamrick K, Geron V, Svoboda LK, Faulk C, Dolinoy DC, Sartor MA. Database (Oxford), 2024 Jan 10; 2024:Journal ArticlepiOxi database: a web resource of germline and somatic tissue piRNAs identified by chemical oxidation.
DOI:10.1093/database/baad096 PMID: 38204359 -
Medeiros MCD, The S, Bellile E, Russo N, Schmitd L, Danella E, Singh P, Banerjee R, Bassis C, Murphy GR, Sartor MA, Lombaert I, Schmidt TM, Eisbruch A, Murdoch-Kinch CA, Rozek L, Wolf GT, Li G, Chen GY, D'Silva NJ. Microbiome, 2023 Nov 30; 11 (1): 268Journal ArticleSalivary microbiome changes distinguish response to chemoradiotherapy in patients with oral cancer.
DOI:10.1186/s40168-023-01677-w PMID: 38037123 -
Morgan RK, Wang K, Svoboda LK, Rygiel CA, Lalancette C, Cavalcante R, Bartolomei MS, Prasasya R, Neier K, Perera BPU, Jones TR, Colacino JA, Sartor MA, Dolinoy DC. 2023 Oct 10;PreprintEffects of Developmental Lead and Phthalate Exposures on DNA Methylation in Adult Mouse Blood, Brain, and Liver Identifies Tissue- and Sex-Specific Changes with Implications for Genomic Imprinting.
DOI:10.1101/2023.09.29.560131 PMID: 37873115