The study focused specifically on one area of the brain that plays a critical role in controlling feeding — the paraventricular nucleus (or PVN) — where neurons express a protein called the melanocortin 4 receptor (MC4R). The work shows that a newly approved drug for severe obesity, setmelanotide, potently activates these neurons in mice.
Indika Rajapakse Publishes in PNAS
Body weight and food intake are tightly controlled by neural circuitry in the brain. Now, a new study from the University of Michigan offers insights into how these circuits operate and respond to feeding and hunger in real-time.