“Our overarching question is how immune cell types in fat are changing,” said Muir. One observation made via mouse studies of obesity is that macrophages change a lot within fat tissue, increasing in number and skewing away from a normal proportion of different types. Furthermore, diabetes combined with obesity also is reflected in changes in macrophages.
- “Human CD206+ macrophages associate with diabetes and adipose tissue lymphoid clusters,” JCI Insight. DOI: 10.1172/jci. insight.146563