Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes, but little is known about their interaction. The group conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without diabetes. Their work suggests that most drug interventions to alter eGFR should be effective in patients with and without diabetes.
Read the full article, "Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals". Commun Biol 5, 580 (2022).