June 14, 2022

DCMB faculty member Cristen Willer contributes to large project focused on genetic effects on kidney function

"Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals". Commun Biol 5, 580 (2022). 

Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes, but little is known about their interaction. The group conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without diabetes. Their work suggests that most drug interventions to alter eGFR should be effective in patients with and without diabetes.

Read the full article, "Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals". Commun Biol 5, 580 (2022). 

Cristen J. Willer, Ph.D.

Cristen J Willer, Ph.D.

Frank Norman Wilson Professor of Cardiovascular Medicine
Professor of Computational Medicine and Bioinformatics
Professor of Internal Medicine
Professor of Human Genetics
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