April 21, 2023

Mapping m6A modification

Kin Fai Au, Ph.D., and his colleagues discovered intriguing patterns of m6A modifications.

Kin Fai Au, Ph.D., Department of Computational Medicine and Bioinformatics, and his collaborators have successfully constructed the landscape of m6A in a mouse embryo, one of the last frontiers for mapping m6A modification.

The team discovered intriguing patterns of m6A modification on genes inherited from the mother versus those activated from the developing embryo. They also found m6A distribution in so called transposable elements, previously thought to be ‘junk’ because they do not encode proteins, in the developing embryo.

Read in the media: "Study reveals pivotal RNA modification in mouse embryos"

Paper cited: “The RNA m6A landscape in mouse oocytes and preimplantation embryos,” Nature Structural & Molecular BiologyDOI: 10.1038/s41594-023-00969-x