October 12, 2023

Obesity leads to a complex inflammatory response inside fat tissue

A new publication by Lindsey Muir and collaborators

A study from Lindsey Muir, Ph.D., Ph.D.-candidate Cooper Stansbury, and their colleagues uses single cell analysis of gene expression combined with spatial transcriptomics to reveal previous unrecognized immune cell types and interactions within adipose tissue. Spatial transcriptomics is a newer technology that captures all gene expression in small spots across an entire thin section of tissue.


Paper cited: “A lipid-associated macrophage lineage rewires the spatial landscape of adipose tissue in early obesity,” JCI Insight. DOI: /10.1172/jci.insight.171701

Additional authors include Gabrielle A. Dotson, Harrison Pugh, Alnawaz Rehemtulla, and Indika Rajapakse.

Lindsey Muir, Ph.D.

Lindsey Muir, Ph.D.

Research Assistant Professor of Computational Medicine and Bioinformatics