Yuanfang Guan, Ph.D.

Yuanfang Guan, Ph.D.

Assistant Professor, Department of Computational Medicine & Bioinformatics
Assistant Professor, Internal Medicine (Nephrology)

2044F Palmer Commons
Ann Arbor MI 48109-2218

734-764-0018

Areas of Interest

Functional genomic data, such as RNA-seq, microarray, protein-protein interactions, are growing exponentially these days. The research in Guan Lab focuses on developing novel and high-accuracy algorithms that integrate these data for predicting gene functions and networks. We have the following ongoing projects in the lab:

1. Modeling dynamic networks: Biological networks may rewire during cell lineage differentiation, tissue development or a disease course. We are actively developing novel algorithms that capture such dynamics. The algorithm contributed by our group (The GuanLab Team) was one of the six best-performance methods (out of over 100 submissions) in the HPN-DREAM 2013 Competition. We achieved the best performance (along another team) to subchallenge 2A, as well as the best aggregate prediction to subchallenges 2A and 2B: network timecourse prediction.

2. Isoform-level analysis: We are exploring algorithms that allow us to go beyond the traditional gene-level analysis to the isoform level.

Published Articles via Michigan Experts or PubMed

Web Sites