The study found that levels of a regulatory protein called ATF4, and the levels of the molecules it controls, are elevated in the livers of mice exposed to interventions known to increase longevity. Elevation of ATF4, at least in the liver, seems to be a shared feature of diets, drugs, genes, and developmental alterations that extend maximum lifespan. According to Dr. Miller, the senior author, "Pathways that appear to change in the same way in many different kinds of slow-aging mice may provide helpful hints towards the design of drugs that keep people healthy longer by slowing most of the diseases of aging. ATF4 seems to be involved in control of aging from yeast to mice, so it's a good bet to be important in human aging, too."
September 11, 2014
Dr. Richard Miller's new study featured in Wiley's News Round-Up
Dr. Miller's new study, published in Aging Cell, is being featured in Wiley's News Round-Up, a biweekly mailing that promotes a selection of the most newsworthy research published across Wiley's journals.