MDRC Molecular Genetics Core

RRID: SCR_015119

The Molecular Genetics Core provides services related to the application of genetic methodologies to research related to diabetes:

Generation of targeted genetic rodent models, using CRISPR/Cas9 system in mouse or rat embryos:
  • Gene edited alleles
  • Knockout alleles
  • loxP-flanked alleles
  • Knock-in alleles (gene insertions, e.g., cre and Flp recombinases, rtTA (“TET-on”), GFP)
  • Cost includes design, construct assembly, embryo injection costs, and screening of potential founders.
  • Application of CRISPR-Cas9 technology in specific genetic backgrounds is available on request, at extra cost.
Generation of specialty viral vectors:
  • Constitutive or cre-inducible AAVs expressing transgenes of interest
  • Cost includes design and construct assembly. Viral production costs are paid directly to the Viral Vector Core by user. ALL costs may be waived for reagents likely to be of general interest, providing that PI is willing to allow distribution to other MDRC members following initial testing.
Specialty viral reagents:
  • Defective pseudotyped rabies viruses for tract-tracing, including AAV helper viruses
  • A panel of general interest cre-inducible AAVs (for list, click here)
  • Under development: AAV-driven CRISPR/Cas9 reagents for gene ablation in animals

Cost of Services

Rates approved through June 30, 2020

* non-UM customers please contact David Olson for quote

Rates with Transgenic Costs Built In (* U-M Customers)

$10,227 per test

$8,867 per test

$10,841 per test

Rates without Transgenic Costs

$4,967 per test

$4,567 per test

$4,332 per test

$3,009 per test

$1,007 per test

$31 per hour

Service Request Form

* External Customers, please download, complete, and return the signed Service Agreement, along with the Service Request form and return to David Olson.

Key Personnel

David P. Olson, MD, PhD

Core Director

Thomas Lanigan, PhD


Huira Kopera, PhD

Vector Core Assistant Director

Dennis Larkin, BS

Research Laboratory Specialist

Qing Zhu, MD

Research Lab Specialist Associate

Contact Us

David P. Olson, MD, PhD

Brehm Tower Room 6442

Remember to cite the Michigan Diabetes Research Center (MDRC) in publications as follows:
“The project described was supported by Grant Number P30DK020572 (MDRC) from the National Institute of Diabetes and Digestive and Kidney Diseases”