MDRC Pilot/Feasibility Study Grant Program Awardees

  • Lucia Russo, PhD, Research Investigator, Pediatrics-Pulmonary Medicine, University of Michigan, “Study of cholesterol 25-hydroxylase in the regulation of adipose tissue inflammation using human approaches”
  • Deqiang Zhang, PhD, Research Investigator, Molecular and Integrative Physiology, “ChREBP acetylation by CLOCK in non-alcoholic fatty liver disease”
  • Emillio Mottillo, PhD, Assistant Scientist, Hypertension and Vascular Research Division, Henry Ford Health System, “Piloting the ABHD5/PNPLA3 metabolon in response to endogenous lipd ligands”
  • Hyunbae Kim, PhD, Research Scientist, Center for Molecular Medicine and Genetics, Wayne State University, “Role of stress-induced miRNA decay in metabolic disorder”
  • Eric Buras, MD, PhD, Clinical Lecturer, Internal Medicine, University of Michigan, “Fibro-adipogenic remodeling of the diaphragm in obesity hypoventilation syndrome”
  • Christian Burgess, PhD, Assistant Professor, Molecular & Integrative Physiology; Research Assistant Professor, Molecular & Behavioral Neuroscience Institute, University of Michigan, “Investigating the relationship between lateral hypothalamic peptide release and energy balance”
  • Laura Saslow, PhD, Assistant Professor, School of Nursing, Department of Health Behavior & Biological Sciences, University of Michigan, “Diet and lifestyle management for obese women with polycystic ovary syndrome”
  • Charles Chung, PhD, Assistant Professor, Physiology, Wayne State University, “Does insulin signaling regulate cardiac stiffness via regulation of titin splicing?”
  • Gina Leinninger, PhD, Assistant Professor, Physiology, Michigan State University, “Contribution of orexin-DLK1 neurons to body weight and behavior”
  • David Bridges, PhD, Assistant Professor, Nutritional Sciences, “The role of adipose tissue in obesity-associated glucocorticoid responses”
  • Isin Cakir, PhD, Research Investigator, Life Sciences Institute, “Reversal of diet-induced obesity with histone deacetylase 6 inhibitors”
  • Ulrike Klueh, PhD, Associate Professor, Biomedical Engineering, Wayne State University, “Development of blood biomarkers for clinical management of diabetic foot ulcers”
  • Suresh Palaniyandi, PhD, Assistant Scientist, Internal Medicine - Hypertension and Vascular Research Division, Henry Ford Health System, “Role for ALDH2 in endothelial cell energy metabolism in diabetic cardiomyopathy: An iPSC approach”
  • Jonathan Flak, PhD, Research Investigator, Internal Medicine, University of Michigan “Uncovering the neurocircuitry that drive counterregulation downstream from the VMN”
  • Carol F. Elias, PhD, Associate Professor, Molecular and Integrative Physiology “Cellular and molecular basis of diabetes-induced placental dysfunction”
  • Robert Wessells, PhD, Assistant Professor, Physiology, Wayne State University “Cardiac lipolysis in Drosophila is controlled by the ABHD5 homolog bremse (CG1882)”
  • Xiangmin Zhang, MD, PhD, Assistant Professor of Research, Pharmaceutical Sciences, Wayne State University “Recombinant attenuated bacteria as drug to initiate insulin synthesis in vivo”
  • Kevin Atkins, MD, PhD, Assistant Research Scientist, Internal Medicine-Nephrology, University of Michigan “The role of GLUT4 on the development of vasculopathy in diabetes”
  • Marianna Sadagurski, PhD, Assistant Research Scientist, Internal Medicine, Geriatrics & Palliative Medicine University of Michigan “Role of growth hormone receptor (GHR) in nutrient-sensing leptin receptor expressing neurons (LEPR-B) in physiology and neuronal function”
  • Renny Franceschi, PhD, Professor, Periodontics & Oral Medicine, School of Dentistry, University of Michigan “Discoidin receptor 2 and adiponectin in energy and mineral homeostasis; relationship to type 2 diabetes”
  • Brigid Gregg, MD, Assistant Professor, Pediatric Endocrinology, Department of Pediatrics, University of Michigan “Understanding the role of metformin during lactation in programming of offspring weight and glucose homeostasis”
  • Wei Perng, PhD, MPH, Department of Nutritional Sciences, SPH, University of Michigan “A prospective study of metabolomics patterns and glycemia in U.S. and Mexican Children”
  • Kyle Burghardt, PharmD, Assistant Professor, College of Pharmacy and Health Sciences, Wayne State University “Insulin resistance induced by antipsychotic medication in the absence of weight gain: impact of skeletal muscle epigenetic and protein mechanisms”
  • Jennifer Hill, PhD, Assistant Professor, Physiology and Pharmacology, University of Toledo “Intergenerational obesity resulting from lactational impairment”
  • Alexander Johnson, PhD, Assistant Professor, Department of Psychology, Michigan State University “Modulation of predictive regulation via chemogenetic and optogenetic control of Melanin Concentrating Hormone”
  • Craig Harris, PhD, Professor of Toxicology, Environmental Health Sciences, University of Michigan “Fetal programming of oxidative stress and insulin resistance”
  • Elizabeth Speliotes, MD, PhD, MPH, Assistant Professor, Internal Medicine-Gastroenterology, University of Michigan “Metabolic studies on Lypla1 mutant mice”
  • Jun Wu, PhD., Research Investigator, Neurology, University of Michigan “The role of activation of RAGE by AGEs in diabetes-induced neuropathic pain”
  • Ren Zhang, MD, PhD, Assistant Professor, Center for Molecular Medicine & Genetics, Wayne State University “Examination of therapeutic potentials of lipasin monoclonal antibodies and the ChREBP-mediated transcriptional regulation”
  • Jian Wang, MD PhD, Assistant Professor, Pathology, Wayne State University “Regulation of glycine metabolism is diabetes”
  • Paula Goforth, PhD, Assistant Research Scientist, Pharmacology, University of Michigan, “Chronic regulation of lateral hypothalamic circuits by leptin”
  • Jennifer W. Hill, Ph.D., Assistant Professor, Physiology and Pharmacology, University of Toledo, “Inflammatory processes driving insulin resistance in polycystic ovary syndrome”
  • Marianna Sadagurski, PhD, Assistant Research Scientist, Internal Medicine, University of Michigan, “Hypothalamic inflammation and energy homeostasis in long-lived mice models and its impact on whole body metabolism and metabolic signaling”
  • Dawn P Misra, PhD, MHS, Professor, Family Medicine and Public Health Science, Wayne State University, “Epigenetic mediators of the obese intrauterine environment”
  • Xin Tong, M.D., PhD, Research Investigator, University of Michigan, “Regulation of lipid metabolism by DDB1-CUL4A E3 ligase in liver steatosis”
  • Jun Li, PhD, Assistant Professor, Human Genetics, University of Michigan, “Genetic analysis of a rat model of aerobic capacity and diabetes risk”
  • Atta Ahmad, PhD, Research Investigator, Life Sciences Institute, University of Michigan, “Examining the role of chaperones in insulin quality control and its relation to type II diabetes”
  • Diane M. Robins, PhD, Professor, Human Genetics, University of Michigan, “KRAB-ZFPs as genetic modifiers of sex-dependent metabolic disease”
  • Anuska V. Andjelkovic-Zochowska, MD, PhD, University of Michigan, Assistant Professor, Pathology, “Blood brain barrier dysfunction in diabetes: The role of miRNA 126 in regulation of blood brain barrier integrity”
  • Gina M. Leinninger, PhD, Assistant Professor, Physiology, Michigan State University, “Role of lateral hypothalamic neurotensin signaling in energy balance and obesity”
  • Xuequn Chen, PhD, Assistant Professor, Physiology, Wayne State University, “Quantitative proteomic analysis of altered ER homeostasis in pancreatic beta cells”
  • Tae-Hwa Chun, MD, PhD, Assistant Professor, Internal Medicine-MEND, “Peri-adipocyte fibrosis and adipocyte dysfunction in diabetes”
  • James Wrobel, DPM, Clinical Associate Professor, Internal Medicine-MEND, “Multi-material, layer, and density approach to shear and pressure reduction in the treatment and prevention of diabetes-related foot ulcer”
  • Jeffrey B. Hodgin, MD, PhD, Assistant Professor of Pathology, “Deep sequencing of the podocyte transcriptome in diabetic and hypertensive mice”
  • David S. Olson, MD, PhD, Clinical Instructor, Pediatrics, Pediatrics and Communicable Diseases, “Translational profiling of neurons involved in feeding”
  • Deneen Wellik, PhD, Associate Professor of Internal Medicine and Cell and Developmental Biology, “The role of Hox6 genes in the pancreatic niche”
  • Menq-Jer Lee, PhD, Associate Professor, Pathology, Wayne State University, “Role of lipolysis activated autocrine sphingosine-1-phosphate signaling in adipocyte function”
  • Roseanne Armitage, PhD, Professor of Psychiatry, “Measurement of sleep physiology in obese and type 2 diabetic patients”
  • Markus Bitzer, MD, Assistant Professor, Department of Internal Medicine, Division of Nephrology, “The role of microRNA-21 in diabetic nephropathy”
  • Christopher Krebs, PhD, Research Investigator, Department of Internal Medicine, Division of Human Genetics, “Distinguishing the mouse RsI genes as genetic modifiers of hepatic insulin sensitivity”
  • David Lombard, M.D., PhD, Assistant Professor, Department of Pathology, Research Assistant Professor, Institute of Gerontology, “Novel mechanisms of pyruvate dehydrogenase complex regulation”
  • Lei Yin, PhD, Assistant Professor, Department of Molecular and Integrative Physiology, “Circadian regulation of AMPK signaling and glucose metabolism by the transcription repressor E4BP4 “
  • Munmum Chattopadhyay, PhD, Research Investigator, Department of Neurology, “Role of neuroinflammation in painful neuropathy in Type 2 diabetes”
  • Alla Karnovsky, PhD, Research Investigator, Center for Computational Medicine & Bioinformatics. “Development and application of bioinformatics tools for metabolomics and diabetes”
  • Joyce Lee, M.D., MPH, Assistant Professor, Department of Pediatrics, Division of Pediatric Endocrinology “The Pediatric Diabetes Consortium (PDC): Improving care in children with type 1 diabetes through collaborative research”
  • Sung Kyun Park, ScD, MPH, Assistant Professor, Department of Environmental Health Sciences, “Bisphenol-A, epigenetics and type-2 diabetes”
  • Scott Pletcher, PhD, Associate Professor, Department of Molecular and Integrative Physiology and Geriatrics, “Identification of novel mechanisms of metabolic homeostasis in Drosophila”
  • Bin Xu, PhD, Research Assistant Professor, Department of Internal Medicine, “Novel function of the RNA activator SRA in adipogenesis”
  • Peter Dempsey, PhD, Associate Professor, Pediatric Gastroenterology, "Role of ErbB4 receptor signaling in the Central Regulation of Energy Metabolism"
  • Carey Lumeng, MD, PhD, Assistant Professor, Pediatrics, “Depot-specific differences in adipose tissue macrophages “Michigan macrophages in adipose tissue”
  • Sandeep Pandit, PhD, Professor, Internal Medicine-Cardiology, “Arrhythmogenesis in type-1 diabetes”
  • Rodica Pop-Busui, MD, PhD, Assistant Professor, Internal Medicine, “Stress induced hyperglycemia: A predictor of long-term glucose abnormalities in patients undergoing cardiovascular surgery?”
  • Bhumsoo Kim, PhD, Research Assistant Professor, Neurology, “Animal models of increased Alzheimer's disease progression with diabetic background”
  • Maria Dolors Sans Gili, PhD, Assistant Professor, Molecular and Integrative Physiology, “Insulin, diabetes and the regulation of pancreatic digestive enzymes”
  • Ming Liu, M.D., PhD, Research Investigator, Internal Medicine, “Dominant negative effects of misfolded proinsulin in pancreatic beta cells”
  • Ayyalusamy Ramamoorthy, PhD, Associate Professor of Chemistry, “Solid-state NMR studies on human islet amyloid polypeptide and its role in beta-cell membrane disruption”
  • Allison Rosen, MD, MPH, ScD, Assistant Professor, Internal Medicine and Health Management and Policy Clinical Director, Center for Value-Based Insurance Design, “Trends in the cost of diabetes care in the United States: 1996-2004”
  • Patrick J. Hu, MD, PhD, Assistant Professor, Internal Medicine, “A novel endocrine pathway regulating insulin-like signaling in C. elegans
  • Jiandie Lin, PhD, Assistant Professor of Cell & Developmental Biology and Life Sciences Institute, “Genome-wide analysis of transcription factors in the regulation of mitochondrial biogenesis by PGC-1α”
  • Julie C. Lumeng, MD, Assistant Research Scientist and Assistant Professor of Pediatrics, “Factors impacting maternal beliefs and feeding practices in mothers of low-income African American Preschoolers”
  • Heike Muenzberg, PhD, Research Investigator, Internal Medicine, “Leptin signaling in the DMH and its role in feeding circuits”
  • Subramaniam Pennathur, MD, Assistant Professor of Medicine, “Molecular mechanisms of pancreatic β-cell failure in vivo