Dr. Silbergleit has expertise in organizing and conducting clinical trials in the acute care setting. He has substantial past experience as a translational researcher, working on laboratory animal models of brain injury, and participating in clinical trials in stroke as a site PI and sub-investigator. For the past seven years, he has been a leading co-investigator in the formation and organization of the Neurological Emergencies Treatment Trials network, where he contributed to the oversight and management of all NETT trials. In the NETT he has developed specific expertise and experience in investigating initial interventions in patients with status epilepticus and neurotrauma. In multiple trials, he has developed operational and academic expertise in Exception from Informed Consent (EFIC) for Emergency Research and its conduct under FDA regulations. He is also PI of a just-funded NIH empirical ethics project to study the review of local context by local and central IRB's.