The goal of my research is to investigate the mechanisms of brain injury caused by cardiac arrest and neuroprotective strategies including targeted temperature management. Cardiac arrest is one of the leading causes of death and disability in the USA. Postcardiac arrest therapeutic hypothermia is the only neuroprotective strategy proven clinically effective after any form of ischemic brain injury. Inadequate understanding of its neuroprotective mechanisms remains a fundamental barrier to optimizing implementation and patient outcomes. In our current research we will investigate the mechanisms of neuroprotection in drug-induced targeted temperature management, determine optimal duration of targeted temperature management after cardiac arrest and compare drug-induced targeted temperature management over external cooling after cardiac arrest. The overall objective of my research project is mechanistic optimization of postcardiac arrest therapeutic hypothermia.