Dr. Barsan is an emergency physician with over 25 years of experience in neurological clinical trials. He was co-principal investigator on the NINDS tPA pilot study from 1986 to 1988 and was co-principal investigator for the University of Cincinnati team in the NINDS tPA study. Since 2006, he has been the principal investigator for the Neurologic Emergency Treatment Trials (NETT) Network Clinical Coordinating Center funded by the NINDS. In this role he is responsible for all aspects of the development, design, and conduct of clinical trials in the NETT. Since 2006, the NETT has conducted several large randomized clinical trials, four of which are still ongoing. In 2010, he was the co-principal investigator on a grant funded by the NIH Common Fund and FDA titled “Accelerating Drug and Device Evaluation through Innovative Clinical Trial Design” (ADAPT-IT). As part of this grant, Dr. Barsan lead the team that developed Bayesian adaptive clinical trials for the NETT and have been performing in mixed methods analysis to evaluate the barriers to adoption and acceptance of these novel clinical trial designs from FDA, NIH, Study Sections, Statisticians and Clinical Trialists. As part of the ADAPT-IT project, this team designed five novel Bayesian adaptive clinical trials, one of which has been recently funded and will begin enrollment in 2015.