Stuart H. Orkin, M.D. presents "Remembrance of Things Past: Reactivation of Fetal Hemoglobin for Therapy" at the 20th Annual James V. Neel Lecture.
May 7, 2021 | 12:00 PM
ZOOM MEETING ID: 983 1136 4189
ZOOM MEETING LINK: https://umich.zoom.us/j/98311364189
Dr. Stuart H. Orkin is the David G. Nathan Distinguished Professor of Pediatrics at Harvard Medical School, and an HHMI Investigator at Boston Children’s Hospital. Orkin has defined the molecular basis of human blood disorders and mechanisms governing blood cell development. Previously he served as Chairman of the Department of Pediatric Oncology at the Dana Farber Cancer Institute from 2000-2016. He received a BS from MIT and an MD from Harvard Medical School. Dr. Orkin served on the National Research Council Committee on Mapping the Human Genome and as co-chair of the Panel to Assess the NIH Investment in Gene Therapy. He was the inaugural chair of the Grants Reviews Committee of the California Institute of Regenerative Medicine (CIRM).
He provided the first comprehensive molecular dissection of an inherited disorder (the thalassemia syndromes), and characterized genes responsible for other human blood disorders, including X-linked chronic granulomatous disease (the first positional cloning). Orkin identified the first hematopoietic transcription factors (the GATA family) and characterized their roles in blood cell development and cancer. His studies of BCL11A, a repressor of fetal hemoglobin (HbF), have illuminated regulation of globin gene switching and improved prospects for HbF reactivation as therapy of the thalassemias and sickle cell disease.
Dr. Orkin was elected to the National Academy of Sciences (NAS), National Academy of Medicine (NAM), American Academy of Arts and Sciences, and the American Philosophical Society, He received the E. Mead Johnson Award, Warren Alpert Prize, Helmut Horten Foundation Prize, Distinguished Research Award from the Association of American Medical Colleges (AAMC), E. Donnall Thomas, Dameshek and Basic Science Mentor Awards of the American Society of Hematology (ASH). He received Jessie Stevenson Kovalenko Medal of the NAS for "important contributions to the medical sciences"(2013), the William A. Allan Award of the American Society of Human Genetics (2014), the George M. Kober Medal of the American Association of Physicians (2018), the Mechthild Esser Nemmers Prize in Medical Science of Northwestern University (2018), the King Faisal Prize in Medicine (2020), the Harrington Prize for Innovation in Medicine (2020), the Tobias Prize Lecture of the International Society of Stem Cell Research (2021), and the Gruber Prize in Genetics (2021).
James V. Neel Lecturers:
- 2021 - Stuart H. Orkin, M.D. (Watch Recorded Video) (Online Program)
- 2020 - Cancelled due to COVID-19
- 2019 - James Lupski (Watch Recorded Video)
- 2018 - Uta Francke
- 2017 - Neil Risch
- 2016 - Andrew Clark (Watch Recorded Video)
- 2015 - Haig H. Kazazian Jr
- 2014 - Richard P. Lifton
- 2013 - Huntington F. Willard
- 2012 - Mary Claire King
- 2011 - David Page
- 2010 - David Botstein
- 2009 - Aravinda Chakravarti
- 2008 - Janet Rowley
- 2007 - Joe Goldstein
- 2006 - Newton Morton
- 2005 - Charles Scriver
- 2004 - Arno Motulsky
- 2003 - James Crow
- 2002 - Cavalli-Sforza
- 2001 - Jack Schull
For more information, contact the Department of Human Genetics, 734-647-3149.