Administrative Contact
Biography
Blood vessels respond to injury and various hemodynamic and metabolic stimuli by changing physiologic properties or mechanical properties such as diameter and wall thickness. This process of structural adaptation, known as vascular remodeling, may improve vascular function or may cause adverse effects, such as occlusion of blood flow, loss of arterial integrity, promotion of thrombotic events, or aneurysm and rupture of the blood vessel. I am a physician scientist, and my laboratory is focused on the genetics of vascular remodeling as it pertains to the development of common diseases, such as hypertension, as well as rare diseases such as fibromuscular dysplasia and spontaneous arterial dissections, which may cause stroke, heart attacks, and severe hypertension in children and adults. We have an interest in mechanisms of sex differences in cardiovascular diseases, and our lab works on a number of diseases that disproportionately burden women or children and have been historically under-studied, and are areas of significant unmet clinical needs. We collaborate across disciplines to ascertain patients and implement a variety of gene discovery approaches and functional modeling approaches in the lab. We investigate novel gene discoveries in mechanistic studies using molecular genetic, cellular, and vascular biology techniques, including in vitro, ex vivo, and in vivo models of disease. We are seeking students with an interest in human genetics, molecular genetics or vascular biology as it pertains to the biologic basis of cardiovascular diseases. Trainees can expect to gain exposure to multidisciplinary collaborations as well as the translational and clinical impact of our research.
Areas of Interest
Genetics and genomics of vascular diseases; arterial dysplasia/ FMD / SCAD / pRVH / MAS / dissections; hypertension
Clinical Interests
Arterial diseases (FMD, arterial dissections including SCAD, arterial aneurysms, renovascular hypertension); genetics; cardiovascular diseases
Honors & Awards
- Alpha Omega Alpha
- NIH Pathway to Independence (PI) Award
- University of Michigan, Cardiovascular Center Heart of a Champion Award
- Founder’s Award, Fibromuscular Dysplasia Society of America
- Election to the American Society of Clinical Investigation (ASCI)
- NHLBI R35 MIRA Award
- Doris Duke Charitable Foundation Paragon Award for Research Excellence
- Biosciences Faculty Achievement Recognition award (MBioFAR), University of Michigan
Credentials
- Postdoctoral Fellowship
National Institutes of Health, NHLBI and NHGRI, Bethesda, United States - Postdoctoral Fellowship
Johns Hopkins Institute of Genetic Medicine, Baltimore, United States - Internal Medicine Residency
University of Michigan, USA - Cardiology Fellowship
Johns Hopkins School of Medicine, USA
Published Articles or Reviews
Full publication list: https://pubmed.ncbi.nlm.nih.gov/?term=santhi+ganesh&sort=date
Selected publications – cardiovascular genetics:
- Yang M, Xu C, Gupte T, Hoffmann TJ, Iribarren C, Zhou X, Ganesh SK. Sex-specific genetic architecture of blood pressure. Nature Medicine. In press.
- Katz A, Ganesh SK. Advancements in the genetics of spontaneous coronary artery dissection. Current Cardiology Reports. In press.
- Xu X, Ganesh SK, Zhou X. mtPGS: Leverage Multiple Correlated Traits for Accurate Polygenic Score Construction. American Journal Human Genetics. 2023; 110(10:1673-1689
- Hesson AM¥, Langen ES, Plazyo O, Gudjonsson JE, Ganesh SK. Placental transcriptome analysis of hypertensive pregnancies identifies distinct gene expression profiles of preeclampsia superimposed on chronic hypertension. BMC Med Genomics. 2023;16(1):91. PMID: 37131171
- Bakker MK, Kanning JP, Abraham G, Martinsen AE, Winsvold BS, Zwart JA, Bourcier R, Sawada T, Koido M, Kamatani Y, Morel S, Amouyel P, Debette S, Bijlenga P, Berrandou T, Ganesh SK, Bouatia-Naji N, Jones G, Bown M, Rinkel GJE, Veldink JH, Ruigrok YM; HUNT All-In Stroke, CADISP group, International Consortium for Blood Pressure, International Headache Genetics Consortium, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity Stroke. 2023; 54(3)810-818. PMID: 36655558
- Katz AE*, Yang M*, Levin MG*, Tcheandjieu C, Mathis M, Hunker KL, Blackburn S, Eliason JL, Coleman DM, Fendrikova-Mahlay N, Gornik HL, Karmakar M, Hill H, Xu C, Zawistowski M, Brummett C, Zoellner S, Zhou Z, O'Donnell C, Douglas JA, Assimes TL, Tsao PS, VA Million Veteran Program, Li JZ, Damrauer S, Stanley JC, Ganesh SK. Fibromuscular dysplasia and abdominal aortic aneurysms are dimorphic sex-specific diseases with shared complex genetic architecture. Circ Precis Med Genom, 2022. Circ Genom Precis Med. 2022; 15(6):e003496 Epub. PMID: 36374587
- Saw J, Starovoytov A, Aymong E, Inohara T, Alfadhel M, McAlister C, Samuel R, Grewal T, Parolis JA, Sheth T, So D, Minhas K, Brass N, Lavoie A, Bishop H, Lavi S, Pearce C, Renner S, Madan M, Welsh RC, McGrath BM, Vijayaraghavan R, Har B, Ibrahim R, Chaudhary P, Ganesh SK, Graham J, Matteau A, Martucci G, Ko DT, Humphries K, Mancini GJ. Canadian Spontaneous Coronary Artery Dissection Cohort Study: 3-Year Outcomes. J Am Coll Cardiol. 2022;80(17):1585-1597. PMID: 36265953
- McAlister C, Alfadhel M, Samuel R, Starovoytov A, Parolis JA, Grewal T, Aymong E, Sedlak T, Ganesh SK, Saw J. Differences in Demographics and Outcomes Between Men and Women With Spontaneous Coronary Artery Dissection. JACC Cardiovasc Interv. 2022;15(20):2052-2061. PMID: 36265936
- Wang Y, Starovoytov A, Murad AM, Hunker KL, Brunham LR, Li JZ, Saw J, Ganesh SK. Burden of Rare Genetic Variants in Spontaneous Coronary Artery Dissection With High-risk Features. JAMA Cardiol. 2022;7(10):1045-1055. PMID: 36103205
- Wang Y, Richer J, Ganesh SK. Letter to the Editor Regarding Lavanya et al. A patient with a novel pathogenic variant in COL5A1 exhibiting prominent vascular and cardiac features. Am J Med Genet Part A. 2022; 188(9):2832-2833. PMID: 35762247. (¥Correspondence author)
- Murad A, Hill HL, Wang Y, Ghannam M, Yang M, Pugh N, Asch FM, Hornsby W, Driscoll A, McNamara J, Willer CW, Regalado E, GenTAC Investigators, Montalcino Aortic Consortium Investigators, Milewicz DM, Eagle KA, Ganesh SK. Spontaneous Coronary Artery Dissection is Infrequent in Individuals with Heritable Thoracic Aortic Disease Despite Shared Genetic Susceptibility. American Journal of Medical Genetics Part A, 2022; 188(5):1448-1456. PMID: 35092149
- 12. Heider A, Gordon D, Coleman DM, Eliason JL, Ganesh SK, Stanley JC.. Histologic and morphologic character of pediatric abdominal aortic developmental coarctation and hypoplasia. J Vasc Surg. 2022. S0741-5214(22): 00237-3
- 13. Kumar N, Zuo Y, Yalavarthi S, Hunker KL, Knight JS, Kanthi Y, Obi AT, Ganesh SK: SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism. Viruses. 2021; 13(11). PM34835015/PMC8617813
- Aslam A, Stojanovska J, Khokhar US, Weinberg RL, Ganesh SK, Labounty T, Sutton NR, Patel S. Spontaneous Coronary Artery Dissection: An Underdiagnosed Clinical Entity-A Primer for Cardiac Imagers. Radiographics. 2021;41(7):1897-1915. PMID: 34652974
- Coleman D¥*, Wang Y*, Yang M, Hunker KL, Birt I, Bergin I, Li JZ, Stanley JC, Ganesh SK. Molecular Genetic Evaluation of Pediatric Renovascular Hypertension due to Renal Artery Stenosis and Midaortic Syndrome in Neurofibromatosis Type 1. Human Molecular Genetics. 2022, 31(3):334-346. PMID: 34476477
- Georges A, Yang ML, Berrandou TE, Bakker M, Dikilitas O, Kiando SR, Ma L, Satterfield BA, Sengupta S, Yu M, Deleuze JF, Dupre D, Hunker KL, Kyryachenko S, Liu L, Amar L, Brumett CM, Coleman DM, d'Escamard V, de Leeuw P, Fendrikova-Mahlay N, Kadian-Dodov D, Li JZ, Lorthioir A, Pappaccogli M, Prejbisz A, Smigielski W, Stanley JC, Zawistowski M, Zhou X, Zoellner S, FEIRI investigators, International stroke genetics consortium (ISGC) intracranial aneurysm working group, MEGASTROKE, Amouyel P, De Buyzere ML, Dobrowolski P, Wojciech W, Gornik H, Olin JW, Piwonski J, Rietzschel ER, Ruigrok Y, Vikkula M, Warchol-Celinska E, Januszewicz A, Kullo IJ, Azizi M, Jeunemaitre X, Persu A, Kovacic JC, Ganesh SK*, Bouatia-Naji N* . Nature Communications. 2021;15;12(1):6031 PMID: 34654805.
- Sun P, Kumar N, Tin A, Zhao J, Brown MR, Lin S, Yang M, Zheng Q, Jia J, Bielak LF, Yu B, Boerwinkle E, Hunker KL, Coresh J, Chen YE, Huo Y, Kardia SL, Khoriaty R, Zhou X, Morrison A, Zhang Y*, Ganesh SK*. Epidemiologic and genetic associations of erythropoietin with blood pressure, hypertension, and coronary artery disease. Hypertension. 2021;78(5):1555-1566. PMID: 34488438
- Grunwald H, Hunker KL, Birt I, Aviram R, Zaffryar-Eilot S, Ganesh SK, Hasson P. Lysyl oxidase interactions with TGF-ß during angiogenesis are mediated by endothelin 1. FASEB J. 2021; 35(9):e21824. doi: 10.1096/fj.202001860RR. PMID: 34370353
- Kim, E; Saw, J, Kadian-Dodov D; Wood, M; Ganesh SK. Fibromuscular dysplasia and spontaneous coronary artery dissection: Sex-biased arterial diseases with clinical and genetic pleiotropy. Circ Res. 2021;128(12):1958-1972. PMID: 34110898 (¥Correspondence authors)
- Persu A, Dobrowolski P, Gornik HL, Olin JW, Adlam D, Azizi M, Boutouyrie P, Bruno RM, Boulanger M, Demoulin JB, Ganesh SK, Guzik T, Januszewicz M, Kovacic JC, Kruk M, Leeuw P, Loeys B, Pappaccogli M, Perik M, Touzé E, Van der Niepen P, Van Twist DJL, Warchoł-Celińska E, Prejbisz A, Januszewicz A. Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia. Cardiovasc Res. 2021; 118(1):65-83. PMID: 33739371
- Sun P, Zhou W, Fu Y, Cheung CYY, Dong Y, Yang ML, Zhang H, Jia J, Huo Y, Willer CJ, Chen YE, Tang CS, Tse HF, Lam KSL, Gao W, Xu M, Yu H, Sham PC, Zhang Y*, Ganesh SK*. An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population. Hum Mol Genet. 2021;30(9):836-842. PMID: 33693786
- Saw J, Yang ML, Trinder M, Tcheandjieu C, Xu C, Starovoytov A, Birt I, Mathis MR, Hunker KL, Schmidt EM, Jackson L, Fendrikova-Mahlay N, Zawistowski M, Brummett CM, Zoellner S, Katz A, Coleman DM, Swan K, O'Donnell CJ; Million Veteran Program, Zhou X, Li JZ, Gornik HL, Assimes TL, Stanley JC, Brunham LR, Ganesh SK. Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction. Nat Commun. 2020;11(1):4432. PMID: 32887874
- Richer J, Hill HL, Wang Y, Yang ML, Hunker KL, Lane J, Blackburn S, Coleman DM, Eliason J, Sillon G, D'Agostino MD, Jetty P, Mongeon FP, Laberge AM, Ryan SE, Fendrikova-Mahlay N, Coutinho T, Mathis MR, Zawistowski M, Hazen SL, Katz AE, Gornik HL, Brummett CM, Abecasis G, Bergin IL, Stanley JC, Li JZ, Ganesh SK. A Novel Recurrent COL5A1 Genetic Variant Is Associated With a Dysplasia-Associated Arterial Disease Exhibiting Dissections and Fibromuscular Dysplasia. Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2686-2699. PMID: 32938213
- Georges A, Albuisson J, Berrandou T, Dupré D, Lorthioir A, D'Escamard V, Di Narzo AF, Kadian-Dodov D, Olin JW, Warchol-Celinska E, Prejbisz A, Januszewicz A, Bruneval P, Baranowska AA, Webb TR, Hamby SE, Samani NJ, Adlam D, Fendrikova-Mahlay N, Hazen S, Wang Y, Yang ML, Hunker K, Combaret N, Motreff P, Chédid A, Fiquet B, Plouin PF, Mousseaux E, Azarine A, Amar L, Azizi M, Gornik HL, Ganesh SK, Kovacic JC, Jeunemaitre X, Bouatia-Naji N. Rare Loss-of-function Mutations of PTGIR are enriched in Fibromuscular Dysplasia. Cardiovasc Res. 2021;117(4):1154-1165. PMID: 32531060
- Coleman DM, Heider A, Gordon D, Ganesh SK, Eliason JL, Stanley JC. Histologic and morphologic character of pediatric renal artery occusive disease. J Vasc Surg. 2020:S0741-5214(20)30474-2. PMID: 32276022
- Coleman DM, Eliason JL, Beaulieu R, Jackson T, Karmakar M, Kershaw DB, Modi ZJ, Ganesh SK, Khaja MS, Williams D, Stanley JC. University of Michigan Pediatric Renovascular Hypertension Center. Surgical Management of Pediatric Renin-mediated Hypertension Secondary to Renal Artery Occlusive Disease and Abdomincal Aortic Coarctation. J Vasc Surg. J Vasc Surg. 2020;72(6):2035-2046. PMID: 32276020
- Sun P, Jia J, Fan F, Zhao J, Huo Y, Ganesh SK*, Zhang Y*. Hemoglobin and erythrocyte count are independently and positively associated with arterial stiffness in a community-based study. J Hum Hypertension. 2021 Mar;35(3):265-273. PMID: 32265488
- Atchison DK, O'Connor CL, Menon R, Otto EA, Ganesh SK, Wiggins RC, Smrcka AV, Bitzer M. Hypertension Induces Glomerulosclerosis in Phospholipase C Epsilon 1 Deficiency. Am J Physiol Renal Physiol 2020 PMID: 32223311
- Hill HL, Stanley JC, Matusko N, Ganesh SK, Coleman DM. The association of intracranial aneursyms in women with renal artery aneurysms. Ann Vasc Surg. 2019;S0890-5096(19)30390-5. PMID: 31200039
- Saw J, Starovoytov A, Humphries K, Sheth T, So D, Minhas K, Brass N, Lavoie A, Bishop H, Lavi S, Pearce C, Renner S, Madan M, Welsh RC, Lutchmedial S, Vijayaraghavan R, Aymong E, Har B, Ibrahim R, Gornik HL, Ganesh S, Buller C, Matteau A, Martucci G, Ko D, Mancini GBJ. Canadian spontaneous coronary artery dissection cohort study: in-hospital and 30-day outcomes. Eur Heart J. 2019;40(15)1188-1197. PMID: 30698711
- Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, de Leeuw P, Fendrikova-Mahlay N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ES, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touzé E, van der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF. First International Consensus on the Diagnosis and Management of Fibromuscular Dysplasia (FMD) on behalf of the Society for Vascular Medicine (SVM) and the Working Group “Hypertension and the Kidney” of the European Society of Hypertension (ESH), Vascular Medicine. 2019;24(2):164-189. PMID: 30648921
- Saw J, Starovoytov A, Humphries K, Sheth T, So D, Minhas K, Brass N, Lavoie A, Bishop H, Lavi S, Pearce C, Renner S, Madan M, Welsh RC, Lutchmedial S, Vijayaraghavan R, Aymong E, Har B, Ibrahim R, Gornik HL, Ganesh S, Buller C, Matteau A, Martucci G, Ko D, Mancini GBJ. Canadian Spontaneous Coronary Artery Dissection Cohort Study: In-hospital and 30-day Outcomes. Eur Heart J. 2019;40(15):1188-1197. PMID: 30698711
- Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, Ganesh SK, Gulati R, Lindsay ME, Mieres JH, Naderi S, Shah S, Thaler DE, Tweet MS, Wood MJ, Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association; American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council. Circulation. 2018;137(19)e523-e557. PMID: 29472380
- Mehta NN, Teague HL, Swindell WR, Baumer Y, Ward NL, Xing X, Baugous B, Johnston A, Joshi AA, Silverman J, Barnes DH, Wolterink L, Nair RP, Stuart PE, Playford M, Voorhees JJ, Sarkar MK, Elder JT, Gallagher K, Ganesh SK, Gudjonsson JE. IFN-γ and TNF-α synergism may provide a link between psoriasis and inflammatory atherogenesis. Sci Rep. 2017;7(1):13831. PMID: 29062018
- van Rooij FJ, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, Keller MF, Chang LC, Schmidt H, Yang ML, Chen MH, Hayes J, Johnson AD, Yanek LR, Mueller C, Lange L, Floyd JS, Ghanbari M, Zonderman AB, Jukema JW, Hofman A, van Duijn CM, Desch KC, Saba Y, Ozel AB, Snively BM, Wu JY, Schmidt R, Fornage M, Klein RJ, Fox CS, Matsuda K, Kamatani N, Wild PS, Stott DJ, Ford I, Slagboom PE, Yang J, Chu AY, Lambert AJ, Uitterlinden AG, Franco OH, Hofer E, Ginsburg D, Hu B, Keating B, Schick UM, Brody JA, Li JZ, Chen Z, Zeller T, Guralnik JM, Chasman DI, Peters LL, Kubo M, Becker DM, Li J, Eiriksdottir G, Rotter JI, Levy D, Grossmann V, Patel KV, Chen CH; BioBank Japan Project., Ridker PM, Tang H, Launer LJ, Rice KM, Li-Gao R, Ferrucci L, Evans MK, Choudhuri A, Trompouki E, Abraham BJ, Yang S, Takahashi A, Kamatani Y, Kooperberg C, Harris TB, Jee SH, Coresh J, Tsai FJ, Longo DL, Chen YT, Felix JF, Yang Q, Psaty BM, Boerwinkle E, Becker LC, Mook-Kanamori DO, Wilson JG, Gudnason V, O'Donnell CJ, Dehghan A, Cupples LA, Nalls MA, Morris AP, Okada Y, Reiner AP, Zon LI, Ganesh SK*¥. Genome-wide trans-ethnic meta-analysis identifies seven genetic loci influencing erythrocyte traits and a novel role for RBPMS in erythropoiesis. American Journal of Human Genetics. Am J Hum Genet. 2017;100(1):51-63. PMID: 28017375
- Kiando SR, Tucker NR, Castro-Vega LJ, Katz A, D'Escamard V, Tréard C, Fraher D, Albuisson J, Kadian-Dodov D, Ye Z, Austin E, Yang ML, Hunker K, Barlassina C, Cusi D, Galan P, Empana JP, Jouven X, Gimenez-Roqueplo AP, Bruneval P, Hyun Kim ES, Olin JW, Gornik HL, Azizi M, Plouin PF, Ellinor PT, Kullo IJ, Milan DJ, Ganesh SK, Boutouyrie P, Kovacic JC, Jeunemaitre X, Bouatia-Naji N. PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance. PLoS Genetics. 2016 Oct 28;12(10):e1006367. PMID: 27792790
- Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJ, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Walter K, Chen L, Yanek L, Becker LC, Peloso GM, Wakabayashi A, Kals M, Metspalu A, Esko T, Fox K, Wallace R, Franceshini N, Matijevic N, Rice KM, Bartz TM, Lyytikäinen LP, Kähönen M, Lehtimäki T, Raitakari OT, Li-Gao R, Mook-Kanamori DO, Lettre G, van Duijn CM, Franco OH, Rich SS, Rivadeneira F, Hofman A, Uitterlinden AG, Wilson JG, Psaty BM, Soranzo N, Dehghan A, Boerwinkle E, Zhang X, Johnson AD, O'Donnell CJ, Johnsen JM, Reiner AP*, Ganesh SK*, Sankaran VG*. Whole exome sequencing identifies novel loci associated with blood cell traits and reveals a role for alternative GFI1B splice variants in human hematopoiesis. Am J Hum Genet. 20164;99(2):481-488 PMID: 27486782
- Pankratz N¥, Schick UM, Zhou Y, Zhou W, Ahluwalia TS, Allende ML, Auer PL, Bork-Jensen J, Brody JA, Chen MH, Clavo V, Eicher JD, Grarup N, Hagedorn EJ, Hu B, Hunker K, Johnson AD, Leusink M, Lu Y, Lyytikäinen LP, Manichaikul A, Marioni RE, Nalls MA, Pazoki R, Smith AV, van Rooij FJ, Yang ML, Zhang X, Zhang Y, Asselbergs FW, Boerwinkle E, Borecki IB, Bottinger EP, Cushman M, de Bakker PI, Deary IJ, Dong L, Feitosa MF, Floyd JS, Franceschini N, Franco OH, Garcia ME, Grove ML, Gudnason V, Hansen T, Harris TB, Hofman A, Jackson RD, Jia J, Kähönen M, Launer LJ, Lehtimäki T, Liewald DC, Linneberg A, Liu Y, Loos RJ, Nguyen VM, Numans ME, Pedersen O, Psaty BM, Raitakari OT, Rich SS, Rivadeneira F, Di Sant AM, Rotter JI, Starr JM, Taylor KD, Thuesen BH, Tracy RP, Uitterlinden AG, Wang J, Wang J, Dehghan A, Huo Y, Cupples LA, Wilson JG, Proia RL, Zon LI, O'Donnell CJ, Reiner AP*, Ganesh SK*. Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits. Nature Genetics. 2016;48(8):867-876. PMID: 27399967
- Davis FM, Eliason JL, Ganesh SK, Blatt NB, Stanley JC, Coleman DM. Pediatric Nonaortic Arterial Aneurysms. Journal of Vascular Surgery. 2016;63(2):466-476.e1. PMID: 26804218
- Saw J, Sedlak T, Ganesh SK, Isserow S, Mancini J. Spontaneous Coronary Artery Dissection (SCAD): Cardiology Patient Page. Circulation. 2015;131(1):e3-5. PMID: 25561479
- Keller MF, Reiner AP, Okada Y, Van Rooij FJ, Johnson AD, Chen MH, Smith AV, Morris AP, Tanaka T, Ferrucci L, Zonderman AB, Lettre G, Harris T, Garcia M, Bandinelli S, Qayyum R, Yanek LR, Becker DM, Becker LC, Kooperberg C, Keating B, Reis J, Tang H, Boerwinkle E, Kamatani Y, Matsuda K, Kamatani N, Nakamura Y, Kubo M, Liu S, Dehghan A, Felix J, Hofman A, Uitterlinden AG, Van Duijn CM, Franco OH, Longo DL, Singleton AB, Psaty BM, Evans MK, Cupples LA, Rotter JI, O’Donnell CJ, Takahashi A, Wilson JG*, Ganesh SK¥* , and Nalls MA* for the CHARGE Hematology, COGENT, and BioBank Japan Project (RIKEN) Working Groups. Trans-ethnic fine-mapping of white blood cell genetic associations. Human Molecular Genetics. 2014; 23(25):6944-60. (*Co-last author; ¥Correspondence author)
- Ganesh SK¥, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang ML, Zhang Y, Ehret G, Rose LM, Hwang SJ, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS, Newton-Cheh C; Global Blood Pressure Genetics Consortium, Raffel LJ, Amin N, Rotter JI, Liu K, Launer LJ, Xu M, Caulfield M, Morrison AC, Johnson AD, Vaidya D, Dehghan A, Li G, Bouchard C, Harris TB, Zhang H, Boerwinkle E, Siscovick DS, Gao W, Uitterlinden AG, Rivadeneira F, Hofman A, Willer CJ, Franco OH, Huo Y, Witteman JC, Munroe PB, Gudnason V, Palmas W, van Duijn C, Fornage M, Levy D, Psaty BM, Chakravarti A.¥ Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. American Journal of Human Genetics. 2014; 95(1):49-65. PMID: 24975945 (¥Correspondence author)
- Ganesh SK¥, Morissette R, Xu Z, Schoenhoff F, Griswold BF, Yang J, Tong L, Yang M, Hunker K, Sloper L, Raza R, Milewicz DM, Francomano CA, Dietz HC, Van Eyk J, McDonnell NB¥. Clinical and biochemical features of fibromuscular dysplasia, a systemic vasculopathy with connective tissue features. (¥Correspondence author). FASEB J. 2014; 28(8):3313-24. PMID: 24732132
- Ganesh SK¥*, Arnett D*, Assimes TL, Basson CT, Chakravarti A, Ellinor PT, Engler MB, Goldmuntz E, Herrington DM, Hershberger RE, Hong Y, Johnson JA, Kittner SJ, McDermott DA, Meschia JF, Mestroni L, O'Donnell CJ, Psaty BM, Vasan RS, Ruel M, Shen WK, Terzic A, Waldman SA; American Heart Association Council on Functional Genomics and Translational Biology; American Heart Association Council on Epidemiology and Prevention; American Heart Association Council on Basic Cardiovascular Sciences; American Heart Association Council on Cardiovascular Disease in the Young; American Heart Association Council on Cardiovascular and Stroke Nursing; American Heart Association Stroke Council. Genetics and Genomics for the Prevention and Treatment of Cardiovascular Disease: A Scientific Statement from the American Heart Association Council on Functional Genomics and Translational Biology. Circulation. 2013;128:2813–2851.
- Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, Gaunt TR, Gho JM, Gieger C, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MF, Mellander O, Molony CM, Nolte IM, Padmanabhan S, Price TS, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, Van Iperen EP, Van Setten J, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JM, Boerwinkle E, Burkley B, Burt A, Chakravarti A, Chen W, Cooper-Dehoff RM, Curtis SP, Dreisbach A, Duggan D, Ehret GB, Fabsitz RR, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, Lacroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R; CARDIOGRAM, METASTROKE, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine CJ, Pettinger M, Polak JF, Ramachandran VS, Ranchalis J, Redline S, Ridker PM, Rose LM, Scharnag H, Schork NJ, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Winkelmann BR, Wyatt S, Young JH, Boehm BO, Caulfield MJ, Chasman DI, Davidson KW, Doevendans PA, Fitzgerald GA, Gums JG, Hakonarson H, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W; LifeLines Cohort Study, März W, Mitchell BD, Murray SS, Oldehinkel AJ, Rader DJ, Reilly MP, Reiner AP, Schadt EE, Silverstein RL, Snieder H, Stanton AV, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Johnson AD, Munroe PB, de Bakker PI, Zhu X, Levy D, Keating BJ, Asselbergs FW. Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet. 2013;22(8):1663-78.