I am a Pediatrician physician scientist with an interest in the mechanisms by which obesity negatively impacts health and disease. I completed MD PhD training at the University of Michigan Medical Scientist Training Program with graduate training in Human Genetics. I perform clinical work as a Pediatric Pulmonology at Mott Children's Hospital.
1. Adipose tissue macrophages (ATMs) as antigen presenting cells - Studies are underway to evaluate communication between macrophage and T cells in fat and how these pathways regulate nutrient metabolism.
2. Mechanisms of ATM activation - With obesity, ATMs take on a pro-inflammatory profile. The mechanisms of this relates to chemokine mediated monocyte trafficking to fat and knockout mice are utilized to identify the critical pathways.
3. Adipose tissue cell diversity - single cell and single nuclear RNAseq approaches are used in human and mouse samples to understand cellular responses to obesity and disease.