Gary Luker, M.D., completed his medical training, residency in diagnostic radiology, and fellowship training in pediatric radiology at Washington University School of Medicine in St. Louis, Missouri. He completed a research fellowship in the Molecular Imaging Center at Washington University prior to coming to the University of Michigan in 2004. His laboratory integrates multi-scale, quantitative imaging studies, cancer biology, and computational modeling to investigate tumor initiation, metastasis, and response to therapy.
The Luker Laboratory employs an integrated approach focused on understanding mechanisms of tumor initiation, metastasis, and response to therapy. We use a variety of imaging methods ranging from sub-cellular resolution to clinical studies in patients with cancer. We combine these imaging methods with engineered tumor environments, animal models of cancer, deep learning methods of image analysis and computational models of cell signaling and function. These studies focus on discovering heterogeneity in tumor environments, including intercellular variations in single cell signaling, cancer stem cells, and spatial/temporal differences in disease at diagnosis. We also employ computational imaging methods to improve early detection of treatment efficacy. Ongoing studies in the lab focus particularly on breast cancer and myelofibrosis.