Heineken graduated from Rutgers University in 2020 with a Bachelor’s Degree in Biochemistry with a concentration in toxicology. During undergrad, she was involved in the IMSD (Initiative for Maximizing Student Development) Scholars Program funded by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health, as well as in Douglass Residential College's Project SUPER, a program that provides opportunities for women in STEM majors to participate in research. Additionally, Heineken conducted her senior honors thesis on the protein mTOR complex 2 under the mentorship of Dr. Estela Jacinto. Before pursuing her graduate studies at the University of Michigan in 2023, she worked as a laboratory technician in Dr. Wei-Xing Zong’s lab at the Ernest Mario School of Pharmacy of Rutgers University for a few years, where she studied arginine metabolism in cancer-associated fibroblasts in the context of pancreatic cancer.
Biography
Research Interest
In collaboration with the Department of Biomedical Engineering at the University of Michigan, Heineken’s lab utilizes a new method of ablation therapy called histotripsy to treat solid tumors. The lab investigates the ability of histotripsy to promote immunostimulation, as well as its potential to overcome current limitations of cancer immunotherapy. Heineken further studies how histotripsy can alter the immune milieu and the microenvironment of solid tumors.
Techniques Used
In vivo and in vitro models; Microscopy; Histology; Flow cytometry; Transfection; Lentiviral transduction; Immunoblotting; qRT-PCR; ELISA
Awards
2024 - Research Training in Experimental Immunology T32 Training Grant, University of Michigan Medical School
2024 - Rackham Conference Travel Grant, University of Michigan
2024 - Trainee Abstract Award, The American Association of Immunologists
2023 - Rackham Merit Fellowship, University of Michigan
2020 - George H. Cook Scholar, Rutgers University
2019 - Phillip Alampi Scholarship, Rutgers University
2017 - Distinguihed Leadership Award, Bergen Commsunity College
2017 - Moses Family Merit Scholarship, Bergen Community College
2016 - Lester Bogen Fund Institutional Scholarship, Bergen Community College
Abstracts
Queen, H., Song, B., Karanam, C., Kim, H., Gatteno, N., Buglak, K., Xu, Z., Cho, C.S., and Ganguly, A. Histotripsy tumor ablation causes vascular anatomic changes that enhance drug delivery. Moses Gunn 35th Annual Research Conference, University of Michigan, 2024. (Poster)
Queen, H., Song, B., Gatteno, N., Karanam, C., Buglak, K., Kim, H., Xu, Z., Olszewski, M.A., Cho, C.S., and Ganguly, A. Investigating the potential of histotripsy to reprogram the tumor microenvironment by altering tumor vasculature. The 22nd Annual Graduate Program in Immunology Retreat, University of Michigan Medical School, 2024. (Poster)
Daguplo, H.Q., Song, B., Gatteno, N., Karanam, C., Buglak, K., Kim, H., Xu, Z., Olszewski, M.A., Cho, C.S., and Ganguly, A. Investigating the potential of histotripsy to reprogram the tumor microenvironment by altering tumor vasculature. The Annual Meeting of the American Association of Immunologists, 2024. (Oral and Poster)
Daguplo, H.Q., Rajput, S., Patel, C., and Jacinto, E. Regulation of P90 Ribosomal S6 Kinase (RSK) Phosphorylation via mTORC2. Project SUPER Research Symposium & Douglass Annual STEM Lecture, Rutgers University, 2019. (Poster)
Daguplo, H.Q. and Kulczyk, A. Structure determination of the mitochondrial helicase Twinkle by cryo-electron microscopy (cryo-EM). RISE at Rutgers Summer Symposium, Rutgers University, 2018. (Oral and Poster)
Daguplo, H.Q., Brincker, M., and Torres, E.B. Autism: The Micro-Movement Perspective. Introduction to Scientific Research Poster Session, Rutgers University, 2018. (Poster)
Hobbies and Extracurricular Activities
When not in the lab, Heineken is either out of state or out of the country, traveling and marveling at the wonders of the world. She also plays instruments and likes to read books of any genre.
Immunology Mentor
