Jazib Uddin

Jazib Uddin, MSc

Immunology Program Graduate Student Candidate

Biography

Jazib graduated from the University of Florida with a B.S in Biochemistry and went on to get his MS in Pharmacology from the University of Cincinnati. Jazib joined the Graduate Program in Immunology in the Fall of 2018, and he joined the lab of Dr. Simon Hogan.

Research Interests

Jazib’s research focuses on the paired immunoglobulin-like receptor (PIRB); an inhibitory receptor which upon activation recruits and activates intracellular phosphatases to inhibit activating kinase signaling pathways. Recent data has identified a previously unappreciated pro-inflammatory role for PIRB in the regulation of CD4+ T-cell-dependent colitis. Jazib is interested in how PIRB regulates CD4+ Th17 pathogenic immune responses in the onset or exacerbation of intestinal inflammation.

Techniques

Flow Cytometry, Magnetic Bead Sorting, DNA/RNA Extraction, Cloning & Transformation, Lentivirus Transduction, Protein Purification, Western Blot. ELISA & IVCCA, Retro orbital Injection, Intraperitoneal Injection, Paraffin Tissue Embedding, H&E Staining, T cell isolation (Lymph Nodes, Spleen), Lamina Propria Isolation, In vitro T cell Differentiation, PBMC Isolation and Purification

Awards

2020 Ruth L. Kirchstein National Research Service Award F31

2020 Rackham Travel Award

2019 Poster Award University of Michigan Immunology Retreat

Abstracts

2020 American Association of Immunologists Meeting, Honolulu, HI. May 09, 2020, Poster Presentation: The Regulatory Role of PIRB in CD4+ Th17 Mediated Colitis; conference canceled

2020 Digestive Disease Week, Chicago, IL. May 04, 2020, Oral Presentation: Paired Immunoglobulin-Like Receptor B Regulates Inflammation and Histopathology in T-Cell Mediated Colitis; conference canceled

2019 University of Michigan Immunology Retreat, Oregon, OH. June 07, 2019, Poster Presentation: Paired Immunoglobulin-like Receptor B Regulates Inflammation and Histopathology in T Cell Mediated Colitis

2018 Autumn Immunology Conference, Chicago, IL. November 17, 2018, Oral Presentation: Paired Immunoglobulin-like Receptor B Regulates Inflammation in T Cell Mediated Colitis

2017 University of Cincinnati Immunology Retreat, Mt. Sterling, OH. October 17, 2017, Poster Presentation: Novel Isoforms of Leukocyte Immunoglobulin-like Receptor B3 in Pediatric UC