Mikel Haggadone

Mikel Haggadone

Immunology Program Graduate Student Candidate

Biography

Mike is a native Midwesterner and proud graduate of the University of Michigan, receiving his B.S. in Cellular and Molecular Biology in 2014 with High Honors and High Distinction. After performing a brief stint of research in California, Mike enthusiastically returned to the University of Michigan in January 2016 to pursue his graduate work in immunology.

Research Interests

Since joining the Peters-Golden lab, Mike has been studying a subset of small, cell-secreted structures called extracellular vesicles (EVs). In the lung, EVs released by the main tissue-resident immune cell, the alveolar macrophage, are concentrated with anti-inflammatory molecules that are taken up by surrounding epithelial cells, which is important for keeping inflammation at bay. From the perspective of a basic biologist, this is also a fascinating phenomenon because it suggests that over time, these two cell types have evolved to depend on one another for generating, secreting, and acquiring homeostatic information that is concentrated in little vesicular packages. However, while the functional importance of these EVs is known, very little is known about how molecular information is specifically concentrated (i.e., sorted) into EVs, which remains a major gap in knowledge in the field. Mike’s thesis work has focused on how the interplay between cell stress responses and metabolic alterations in alveolar macrophages regulates vesicular sorting and release of anti-inflammatory cargoes.

Techniques

Western blot, flow cytometry, nanoparticle tracking analysis, RT-qPCR

Awards

2020 Monte V. Hobbs Student Award (2020)
2019 Abstract Scholarship (American Thoracic Society
2019 International Conference) - Assembly on Allergy, Immunology and Inflammation
2019 Herman and Dorothy Miller Research Recognition Award - University of Michigan Graduate Program in Immunology
2018 Scientist Spotlight - University of Michigan Office of Graduate and Postdoctoral Studies
2018 Award for Excellence in Teaching - University of Michigan Office of Graduate and Postdoctoral Studies
2016 Graduate Research Fellowship - National Science Foundation
2014 High Honors in Cellular and Molecular Biology - University of Michigan Program in Biology
2014 Bachelor of Science, with High Distinction - University of Michigan College of Literature, Science, and the Arts
2014 Sidney Fine Teaching Award - University of Michigan College of Literature, Science, and the Arts Honors Program
2014 Phi Beta Kappa Society - Alpha of Michigan Chapter
2013 Undergraduate Research Fellowship - American Heart Association
2013 Honor Society of Phi Kappa Phi - University of Michigan Chapter
2012 Research Internship in Science and Engineering - German Academic Exchange Service
2011 Outstanding Poster Award - University of Michigan Undergraduate Research Opportunity Program Symposium

Abstracts

Haggadone, MD, Speth, J, Hong, H, Zhang, E, Lyssiotis, CA, and Peters-Golden, M. Homeostatic release of vesicular suppressor of cytokine signaling 3 by alveolar macrophages requires glycolytic restraint. Am. J. Respir. Crit. Care Med. (2020) 201:A6504.

Haggadone, MD, Zhang, E, and Peters-Golden, M. Degradation of extracellular vesicles by enzymatic allergens. Am. J. Respir. Crit. Care Med. (2019) 199:A2952.

Haggadone, MD, Mancuso, P, Bazzill, J, Moon, JJ, and Peters-Golden, M. Reactive oxygen species enhance suppressor of cytokine signaling 3 packaging into alveolar macrophage-derived microvesicles. Am. J. Respir. Crit. Care Med. (2018) 197:A4488.

Grailer, J, Haggadone, M, and Ward, P. Catecholamines promote an M2 macrophage activation phenotype. J. Immunol. (2013) 190:63.7.

Hobbies and Extracurricular Activities

In addition to his scientific pursuits, Mike is an avid runner and competes in trail ultra-marathons as a member of the Some Work, All Play Adventure Team. Mike also runs for Bigger Than The Trail, a non-profit organization that raises money to support mental health counseling for those in need. When not in lab or outside running, Mike thoroughly enjoys reading, writing, and spending time with friends in the Graduate Program in Immunology.