Patrick Coit

Patrick Coit, MPH

Immunology Program Graduate Student Candidate

Biography

I received my Bachelor of Science degree in Microbiology from Oklahoma State University in 2011. I started as a research technician in the Sawalha lab and moved to the University of Michigan in 2012 to continue pursuing research in the role of DNA methylation in autoimmunity. While here, I completed a two year Master of Public Health program in Hospital & Molecular Epidemiology at the University of Michigan School of Public Health.

Research Interests

My research interests include studying epigenetic and gene expression changes in immune cells that contribute to autoimmunity, especially lupus, and how these changes can track disease activity in the clinic. I am also interested in how the host salivary microbiome changes in lupus patients with disease activity. In addition, I apply a variety of statistical and bioinformatics tools and methods for the analysis and visualization of genome-wide epigenetics and transcriptional data and perform follow up functional studies.

Awards

2011 Honor’s College Degree Oklahoma State University

2010 Lew Wentz Research Scholarship Oklahoma State University

2014 School of Public Health Dean’s Tuition Award University of Michigan

 

Abstracts

ACR/ARHP Annual Scientific Meeting - November 2012 Washington, D.C.

Direskeneli H, Coit P, Ture-Ozdemir F, Alibaz-Oner F, Saruhan-Direskeneli G, Jeffries M, Sawalha AH, A Genome-Wide DNA Methylation Study Identifies Significant Epigenetic Changes Across the Genome and in Multiple HLA Loci in Behcet's Disease. (Poster)

ACR/ARHP Annual Scientific Meeting - October 2013 San Diego, CA

Coit P, Hughes T, Koelsch K, Scofield R, Sivils K, Farris A, Sawalha AH, Altorok N. Genome-wide DNA methylation patterns in naïve CD4+ T cells from patients with primary Sjogren’s syndrome. (Oral Presentation: Nezam Altorok)

ACR/ARHP Annual Scientific Meeting - November 2014 Boston, MA

Coit P, Yalavarthi S, Zhao W, Kaplan MJ, Sawalha AH. Epigenome Profiling Reveals Robust Hypomethylation of Interferon Signature Genes in Lupus Neutrophils. (Poster)

Coit P, De Lott LB, Nan B, Elner VM, Sawalha AH. DNA Methylation Analysis of the Temporal Artery Microenvironment Reveals a Robust T Cell Signature and Suggests a Role for TNF-α in Giant Cell Arteritis. (Oral Presentation: Patrick Coit)

ACR/ARHP Annual Scientific Meeting - November 2015 San Diego, CA

Coit P, Yalavarthi S, Knight JS, Sawalha AH. Neutrophils in Primary Antiphospholipid Syndrome Are Characterized by a Prominent Activated Phenotype and Uniquely Remodeled Chromatin Architecture. (Poster)

Microbiome Group Seminar Series – September 2016 Ann Arbor, MI

Coit P, Mumcu G, Ture-Ozdemir F, Unal AU, Alpar U, Bostanci N, Ergun T, Direskeneli H, Sawalha AH. Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behçet's disease (Oral Presentation: Patrick Coit)

17th International Conference of Behcet’s Disease – September 2016 Matera, Italy

Coit P, Mumcu G, Ture-Ozdemir F, Unal AU, Alpar U, Bostanci N, Ergun T, Direskeneli H, Sawalha AH. Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behçet's disease (Poster) ACR/ARHP Annual Scientific Meeting - November 2016 Washington, D.C. Coit P, Mumcu G, Ture-Ozdemir F, Unal AU, Alpar U, Bostanci N, Ergun T, Direskeneli H, Sawalha AH. Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behçet's disease (Poster)

Renauer P, Coit P, Strickland F, Gensterblum E, Ognenovski M, Richardson B, Sawalha AH. Demethylated CD4+CD28+KIR+CD11ahi T Cells Are Characterized by a Pro-Inflammatory Transcriptome and Interact with Genetic Risk to Predict Disease Activity in Lupus (Poster)