Webinar: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. Qian Zhang and her team identified autosomal-recessive or autosomal-dominant deficiencies of genes in the type I IFN circuit in 23 patients (3.5%) 17 to 77 years of age. She will show that inborn errors of TLR3- and IRF7- dependent type I IFN