Job Postings

Two Post-doctoral positions are open immediately in the laboratory of Laura Santambrogio M.D. Ph.D, at Weill Cornell Medical in New York City. The ideal candidates would have at least 2 years experience in cellular immunology with focus on FACS analysis of T cells and Dendritic Cells sub-populations, primary cell cultures and antigen presentation assays.  The stipend is in accordance with NIH tables.  Candidates should send their CV and names and contact information of 2-3 recommending faculty at [email protected]

Laura Santambrogio M.D. Ph.D
Associate Director Precision Immunology
Englander Institute of Precision Medicine
Professor Radiation Oncology
Professor Physiology and Biophysics
Weill Cornell Medicine
1300 York Avenue Room E215
New York, NY 10065
tel 646-962-2160

A Postdoctoral Scholar Position is currently available in the lab of Professor Katherine Wall, Chair of Medicinal and Biological Chemistry, at the University of Toledo in Ohio. The ideal candidate will have experience in immunology and immunological assays, particularly using mouse models. Candidates must have earned a PhD in Immunology, Biochemistry, or a related field with a focus on Immunology or have equivalent experience.

The project goals related to the position are the analysis of immune responses of mice to novel Pseudomonas aeruginosa vaccine designs prepared by a chemist co-PI on a new R01 NIH grant. The duties include managing the laboratory and assisting with several graduate students. This postdoctoral position is open immediately and will remain open until filled.

All interested candidates are required to apply online at https://utoledo.csod.com/ux/ats/careersite/6/home/requisition/1913?c=utoledo and submit a cover letter that provides their research experience and availability, a curriculum vitae, and three reference letters.

Further questions about this position can be sent directly to [email protected]  with the subject line Postdoctoral Scholar.

The University of Toledo is an equal opportunity, affirmative action employer. The University of Toledo does not discriminate in employment, educational programs, or activities on the basis of race, color, religion, sex, age, ancestry, national origin, sexual orientation, gender identity and expression, military or veteran status, disability, familial status, or political affiliation.

An Immunology Postdoctoral Position in Philadelphia is available immediately in the lab of David Wiest at Fox Chase Cancer Center. My lab has a longstanding history of investigation into the molecular mechanisms controlling lymphoid development and transformation. We have the following exciting projects available: 

1. Analysis of the role on molecular control of gd T cell lineage commitment and effector fate, including the role of lncRNA, using genome wide approaches
2. Investigation of the regulatory functions of ribosomal proteins in controlling hematopoietic development and transformation, with a particular focus on alterations in cell metabolism.
3. Elucidation of novel domain-specific functions of ERK in cancer etiology and immunotherapy.
4. Identification of novel regulators of lymphoid development by elucidating the molecular etiology of human immunodeficieny using zebrafish as a model.

In pursing these projects, we integrate mouse and zebrafish models with human data and samples and exploit genomic and proteomic approaches, as well as genome editing. Opportunities are available to learn not only how to perform wet “omic” analysis, but also how to perform the bioinformatic analysis necessary to maximally benefit from these approaches. Experience with mouse models and/or zebrafish is advantageous. Fox Chase is located in a safe suburban neighborhood with easy access to the city. More information about my research can be found at: https://www.foxchase.org/david-wiest. Please send CV and 3 references to David Wiest at: [email protected]

See description on the Center for Eosinophilic Disorders website

Job description

This Postdoctoral Fellow position is in the Division of Allergy and Immunology, Department of Pediatrics at the Icahn School of Medicine at Mount Sinai. The Postdoctoral Fellow will will in conjunction with the Principal Investigator (Mirna Chehade, MD, MPH) at the Mount Sinai Center for Eosinophilic Disorders (MSCED), investigating the immunopathology of eosinophilic esophagitis (EoE).

We are seeking a highly motivated individual to work in the field of eosinophilic gastrointestinal disorders. The successful candidate will participate in a research project focused on the effect of proton pump inhibitors (PPI’s) on the esophageal transcriptome in EoE subtypes, and the role of various immune and signaling pathways in PPI-mediated suppression of esophageal eosinophilia. The candidate will be participating in an exciting journey intergrating in silico and wet Lab approaches to establish a new paradigm for translating gene expression profiles into mechanistic insights and eventually personalized precision patient care. In silico approaches including analyses of NGS data (including genome wide association studies, RNA sequencing (single cell and whole tissue)), bioinformatics strategies to study the genetic basis of EoE, and wet Lab assays including molecular analyses of primary esophageal cell culture systems, will be conducted.

Qualifications

The successful candidate must hold a PhD or equivalent degree with a background knowledge in immunology. Working knowledge of principles of immunology and molecular biology is required. The candidate must also demonstrate competency in RNA isolation from tissue/cells, RNAseq analysis and immunohistochemistry, as well as demonstrated experience in cell culture techniques, qRT-PCR, cytokine assays and flow cytometry. The candidate will have access to highly collaborative research teams with expertise in the required areas of research, including the Center for Bioinformatics and the Genomics Core and Pathology Core Facilities at the Icahn School of Medicine at Mount Sinai in New York City.

As the current MSCED team members have a strong clinical background and are all highly invested in research, the candidate will present data to the team. Ability to work autonomously with minimal supervision and collaboratively as part of the MSCED team, and ability to analyze and communicate experimental results clearly to other team members is required. Exceptional work ethic, strong written and verbal communication skills, strong organizational skills and ability to multi-task and prioritize are required for the position.

This is a unique opportunity to develop expertise in this growing area of EGIDs, which can serve as a platform for a potential future career as an independent research investigator at the MSCED.

Offer

The MSCED will provide the candidate with necessary support on all aspects of the project.

Full-time employment at Mount Sinai includes a competitive salary, medical/dental/vision benefits, paid vacation/sick leave, and employer contributions to a retirement plan (403b). 

Apply

Interested candidates should include their full curriculum vitae, a cover letter briefly stating their career goals, specific research experience and areas of interest, and contact information of three references in their application, and send it to: [email protected]

The Molecular Enzymology Division of New England Biolabs (NEB) is inviting applications for a Postdoctoral Fellow to conduct research on phage 5mC and T-hypermodifying enzymes. The successful applicant will employ high throughput in vivo and in vitro functional screening techniques to discover and biochemically characterize novel enzymes. Select enzymes with intriguing chemistries will undergo detailed kinetic characterization for more in-depth understanding of their modes of function. Research will be undertaken in a highly collaborative and intellectually open environment where publication of results is expected.

Primary Responsibilities:

• Develop high throughput workflows using robotic handling systems for discovery of new 5-methylpyrimidine hypermodifying enzymes.
• Explore a variety of analytical methods such as LC-MS, LC-MS/MS, fluorescence, etc. for product detection.
• Elucidate pathways of 5-methypyrimidine hypermodification and reconstitute them in vitro.
• Express, purify, and kinetically characterize enzymes with novel chemistries.
• Collaborate with investigators at NEB and in academia.
• Communicate findings to the scientific community through publications and presentations.

Required Qualifications:

• Ph.D. in enzyme biochemistry, natural products biosynthesis, synthetic chemistry, or related field
• Protein expression and purification skills.
• A strong foundation in enzyme chemical mechanisms.
• A strong foundation in functional assay design.
• A strong foundation in chemistry.
• Strong analytical skills.
• Strong record of scientific publication.
• Strong collaborative and interpersonal skills.
• Excellent verbal and written communication skills.

Preferred Qualifications:

• Familiarity with techniques of analytical chemistry such as HPLC, MS, and fluorescence.
• Familiarity with steady-state and transient-state kinetics.
• Experience in Synthetic Chemistry.
• Desire to gain experience on robotic handling systems.
• Personal drive to lead a project in a technically challenging field.
• Willingness to learn and master new techniques 

This position offers exciting opportunities for broad research training, collaboration with academic institutions, publishing in peer-reviewed journals and participation in national and international conferences.

How to Apply

Please apply on the NEB Website

Description:

A postdoctoral position is available in the  The group focuses in characterizing mechanisms that lead to immune dysregulation, loss of immunologic tolerance and end organ damage in systemic autoimmune diseases such as systemic lupus erythematosus. The successful candidate will employ innovative approaches to understand how the innate immune system contributes to the development of autoimmune disorders, integrating use of human and murine systems with omics technologies and functional studies.

Qualifications:

We seek highly motivated, collaborative and creative individuals with MD, PhD or MD PhD and less than 5 years of postdoctoral experience. Previous experience in cellular/ molecular biology, systems biology analysis and/or animal models of disease is desirable. The candidate should have excellent writing and communication skills.

To apply:

Please send a research statement, CV and names and contact information of 3 professional references to :
Mariana Kaplan, MD
Systemic Autoimmunity Branch, NIAMS
[email protected]

The laboratory of Dr. Marlene Bouvier in the Department of Microbiology and Immunology of UIC has an immediate opening for a Research Scientist or Postdoctoral Associate, based on number of years of research experience after PhD, to play an active role in our ongoing studies of immune evasion mechanisms involving Adenovirus and immune cell surface receptors. We are seeking a highly motivated and intellectually curious individual with a rigorous training in virology/immunology and advanced hands on experience in molecular biology and other techniques such as generation of virus stocks, determination of virus titers, acquisition and analysis of flow cytometry data, quantitative PCR, cell-based and biochemical assays, electrophoresis techniques, and maintenance of mammalian cells. The selected candidate will have the opportunity to gain knowledge in structural virology/immunology.

For immediate consideration, please submit a cover letter to [email protected] and complete resume. 

Do you have a background in immunology and are interested in translational medicine? If so, a postdoctoral fellowship position is available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic.

We recently discovered the genetic basis for sex steroid metabolism that regulates distinct clinical immune and inflammatory response in humans (Zein, et al. PNAS. 2020; 117(4) 2187-2193). The steroid metabolism
consequences on androgen synthesis is something our group has worked out in great detail (Chang, et al. Cell. 2013;154:1074-84; Hearn, et al. Lancet Oncol. 2016;17:1435-44; JAMA Oncol. 2018;4:558-62). We have
discovered steroid metabolism drivers that dictate a general mechanism of human physiology that impinges on multiple pathophysiologic disease processes.

We are searching for an incisive and highly driven postdoctoral fellow in immunology to dissect the mechanisms by which specific downstream sex steroids (i.e., androgens and estrogens) conduct the immune response.

The fellow will be embedded in a unique and multidisciplinary environment with exposure to tumor metabolism, molecular oncology, endocrine physiology, drug development and clinical trials. Further details are available at:
http://www.lerner.ccf.org/cancerbio/sharifi/

The ideal candidate has a Ph.D. degree in immunology or molecular immunology and is highly driven. Outstanding verbal and communication skills are required. Interested candidates should send their CV and contact
information for 3 references to:

Nima Sharifi, M.D.
Kendrick Family Chair for Prostate Cancer Research
Director, GU Malignancies Research Center
[email protected]

Principal Investigator:

Daria Babushok, MD PhD

Assistant Professor of Medicine

Division of Hematology-Oncology, Abramson Cancer Center

Perelman School of Medicine at the University of Pennsylvania

Member of Penn Immunology and Cell and Molecular Biology Graduate Groups

Research Area:

The Babushok Laboratory at the University of Pennsylvania aims to understand the underlying mechanisms of autoimmune bone marrow failure disease called aplastic anemia and to elucidate drivers of pre-malignant clonal evolution in bone marrow failure disorders. The long-term goal of the laboratory is to translate the improved understanding of the pathogenesis of aplastic anemia and related bone marrow failure disorders into better patient outcomes through more precise diagnostics and rationally-designed, more effective therapies. The laboratory seeks a creative and motivated Postdoctoral Fellow to join our team to study the mechanisms of autoimmunity and immune evasion in aplastic anemia and related disorders. 

https://www.med.upenn.edu/babushoklab/

Qualifications:

Highly motivated candidates with a recent or shortly anticipated Ph.D. and a record of accomplishment (e.g., one or more first-author research publications) in an immunology-related field are encouraged to apply. Experience with mouse models is preferred. The candidate must be able to work independently and collaboratively within a larger research team. The candidate must have excellent analytical skills, be a creative thinker, be able to learn and troubleshoot new techniques, maintain accurate research records, and have excellent personal and communication skills.

Salary: 

Commensurate with experience and according to the NIH guidelines.

How to Apply: 

Candidates should send inquiries including a CV, contact information for three references, and a brief (less than 1 page) statement describing their research background and interests to [email protected]

This position contributes to the education of graduate students at Marian University by providing instruction in the Biomedical Sciences (BMS) Masters of Science program that will allow learners to acquire a competence with the fundamental concepts and facts related to the cellular and molecular make up of microorganisms, especially those pathogenic for humans, their interactions with the host defenses of human beings and their mechanisms of pathogenicity and effects on populations. Approaches to treatment and prevention of infectious disease are within the scope of this discipline. This faculty member provides expertise in microbiology and immunology using skills and experience to provide leadership for finalizing and overseeing assigned parts of the graduate curriculum. The faculty member will engage in evaluation of the curriculum and contribute to mentorship development of graduate students. The faculty is expected to be available to mentor thesis track students and develop a research program consistent with other research active members of the BMS program. Opportunities may arise to deliver instruction in the osteopathic medical school Doctor of Osteopathic Medicine program.

Additional Responsibilities include the following: 

• Faculty members of the MU-COM who provide training in microbiology and immunology contribute to the mission and success of the college and the success of its students through excellent teaching, scholarly activity and service to the University and community.
• Faculty participate in the development, delivery, evaluation and improvement of the curriculum
• Supervise and direct active learning by the students in microbiology and immunology courses
• Faculty are responsible for developing appropriate programs contributing to research and scholarly activity
• Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
• Other duties may be assigned

Requirements:

• A successful applicant will have an earned PhD in Microbiology, Immunology or a related field and have demonstrated expertise in these areas.
• To perform this job successfully, an individual must be able to perform each essential duty satisfactorily.

About Maria University

Founded in 1937 by the Sisters of St. Francis, Oldenburg, Indiana, Marian University is the only Catholic university in Indianapolis and central Indiana. In 2019, Marian is serving more than 2,400 undergraduate and 1,160 graduate students earning degrees in the arts, business, education, engineering, math, medicine, nursing, ministry, and the natural and physical sciences. The university’s high-impact, experiential curriculum is designed to provide hands-on, collaborative learning opportunities for students from 45 states and 23 nations. Marian climbed in U.S. News & World Report’s 2020 Midwestern rankings to be named #6 Most Innovative Regional University, #15 Best Value University, and #30 Best Regional University. Marian University opened its College of Osteopathic Medicine in 2013, making it the first new school of medicine in the state of Indiana in 110 years. Marian’s national champion varsity athletic programs include the 2012 and 2015 NAIA Football National Championship, the 2016 and 2017 NAIA Women’s Basketball Championship, and more than 40 USA Cycling national championships.

Review of applications will begin on January 6, 2020 and continue until the position is filled. Please send a letter of application, a current CV, three letters of recommendation. All applications should be submitted to [email protected]. Please include the Position Title in the subject of your email

The Immuno-oncology Institute is hiring 30 faculty.
Applications will be accepted until the positions are filled.

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) is seeking experienced tenure-track faculty (basic as well as clinical researchers) to work in the recently announced Pelotonia Institute for Immuno-Oncology (PIIO) in the following research areas:

• T-cell biology
• Innate immunity and inflammation
• Immune regulation and tolerance
• Cell therapy, synthetic immunology, immunogenomics and cancer vaccines
• Translational and clinical immuno-oncology (IO)
• Immune monitoring and discovery

How to Apply

Send cover letter, CV, 2-3 page description of current and future research interests, and contact information for three references via email to Tamra Brooks at [email protected].

Overview:

The Center for Immunobiology at the Western Michigan University Homer Stryker MD School of Medicine and its Director, Thomas L. Rothstein MD, PhD, invite applications for faculty positions at the rank of Assistant/Associate Professor. The Center's current focus is on the development and function of B cells in health and disease, and encompasses both human and mouse systems. Candidates sought include those with broad based research experience and expertise in cellular immunology, molecular biology, stem cell development, and/or intracellular signaling, pertaining to B cells. Appointments will be in the Department of Biomedical Sciences, within which the Center is located.

Responsibilities:

The successful candidate is expected to develop and maintain an innovative and independent research program supported by extramural funding. Desirable qualifications include the potential for productive research interactions with faculty colleagues within the Center and the Department. The position offers a generous start-up package with competitive compensation and comprehensive benefits in a progressive environment.

Qualifications:

Preference will be given to applicants with a recognized record of accomplishment as evidenced by scholarly publications in the field of B cell immunobiology and demonstrated ability or strong potential to obtain extramural funding to support their work. Qualified applicants must have a PhD, MD or MD/PhD degree, and postdoctoral research training. Academic rank and salary are commensurate with experience.

About the Center for Immunobiology

The Center for Immunobiology is a 3 year old division within the medical school. The Center is endowed with the very latest instrumentation to speed research discovery. The flow cytometry and imaging core contains BD Influx (2) and Melody cell sorters, Fortessa and Thermo Fisher Attune flow cytometers, a Nikon confocal microscope, and a BioTek Lionheart automated microscope; the sequencing core includes an Illumina MySeq sequencer, an Applied Biosystems (Sanger) SeqStudio sequencer, and a 10x Genomics instrument for single cell experiments; the tissue culture core includes 6 Class II biosafety cabinets, 4 CO₂ incubators, 1 tri-gas incubator, 2 refrigerated table top centrifuges, 1 inverted phase microscope, 1 -20^oC freezer and 1 4^oC refrigerator; the radioisotope core contains a Perkin-Elmer Betaplate counter and an LKB gamma counter, a biosafety cabinet and CO2 incubator, a 96 well cell harvester and 2 ³²P workstations; the BL2 core contains 2 biosafety cabinets and CO₂ incubators, 2 refrigerated table top centrifuges, 2 inverted phase microscopes, a cell counter, and    -80^oC and -20^oC freezers; and the equipment core contains a QuantStudio 3D digital PCR system, a QuantStudio 3 RealTime PCR cycler, a Bio-Rad FPLC system, a Bio-Rad gel doc system, a Bioruptor Plus sonicator, a 4D-Nucleofector, a CTL multi-spectral ELISPOT reader, 2 Savant speedvacs, a BioTek visible/fluorescence/bioluminescence microplate reader, a BioTek microplate washer, 3 bacterial incubator shakers, and ultra, superspeed, and cytospin centrifuges, among other items. A separate room houses -80^oC freezers and liquid nitrogen tanks, and a dark room houses an X-ray developer. The Center floor includes a walk-in cold room, a conference room, and a break room.  The animal facility is located on the same floor and contains a PXi X-RAD 320 irradiator and a BL2 facility for in vivo work with infectious agents.  The Research Histology Laboratory and The Center for Neuropathology are located one floor below. Support for the Center includes a flow cytometer/cell sorter/imaging core manager, a sequencing core manager, and a business and operations manager.

About Western Michigan University School of Medicine (WMed)

As one of the newer US medical schools, WMed is an exciting environment in which to pursue an academic career. The medical school is a collaboration of Western Michigan University, which ranks among the 50 largest colleges and universities and among the top 100 national public doctoral universities in the US, with Kalamazoo's two teaching hospitals, Borgess Health and Bronson Healthcare. To house the medical school, the 350,000 square foot primary educational building on the W.E. Upjohn MD Campus located in downtown Kalamazoo underwent a $68 million renovation and expansion project. An additional $10 million renovation created space devoted to laboratory research. The medical school operates its own clinics, housed in a separate 60,000 square foot clinical building on the nearby Oakland Drive Campus. In 2016 the Innovation Center, a biotech incubator on the Parkview Campus, became part of the medical school. WMed is a private 501(c)(3) nonprofit corporation supported by private gifts, clinical revenues, research activities, tuition, and endowment income. The medical school has been granted accreditation from the Liaison Committee on Medical Education, and has graduated 2 classes of future doctors. WMed is also accredited by the Accreditation Council for Continuing Medical Education (ACCME) for continuing medical education.

About Kalamazoo

Kalamazoo is a wonderful and vibrant city, located midway between Chicago and Detroit. It is a short distance from Lake Michigan, and home to two nationally ranked institutions of higher learning, Western Michigan University and Kalamazoo College. Kalamazoo is known for its community focus and emphasis on access to quality education at all levels. The Kalamazoo Promise is a nationally recognized program in which graduates of Kalamazoo Public Schools receive free tuition to attend public and private colleges in Michigan. At the other end of the educational continuum, the Kalamazoo Ready 4s program ensures that every 4-year-old in Kalamazoo County has the opportunity to attend a high-quality pre-kindergarten program, regardless of ability to pay. Kalamazoo and Michigan provide extensive entertainment and recreational activities, including opportunities to enjoy the outdoors, unique restaurants and shops, and a strong culture supporting the arts.

How to Apply 

Interested and qualified applicants should apply online. 

Direct questions about the position to the Director at [email protected].  

Western Michigan University Homer Stryker MD School of Medicine is an Equal Employment Opportunity/Affirmative Action employer of females, minorities, individuals with disabilities, and protected veterans, and actively strives to increase diversity within its community. WMed provides a drug- and tobacco-free workplace.

The Broad Institute is an amazing place – we exist to apply our deep knowledge of human genetics to empower a revolution in biomedicine and accelerate the pace at which the world conquers disease. Within the Broad Institute, the Center for the Development of Therapeutics (CDoT) is a team of professional “drug hunters” who, through partnerships with faculty at MIT, Harvard and the Harvard teaching hospital, seek to translate emerging biological insights into novel therapeutic strategies. We couple novel technologies and approaches with industry-leading drug discovery rigor to tackle some of the most challenging targets across a wide range of disease areas including oncology, cardiovascular disease and diabetes, psychiatric disease, infectious disease, and inflammation.

Job Description

We are currently seeking a dynamic cancer immunologist to join the CDoT Translational Pharmacology team. In this role, you will bring your knowledge of cancer immunology along with cell-based and in vivo assay development to tackle new drug discovery challenges. Working within multi-disciplinary teams of academic and industrial scientists including biochemists, structural biologists, medicinal chemists, in vivo pharmacologists and academic cancer immunology experts, you will drive the development and execution of cell-based and in vivoassays to empower the discovery and development of novel immune-oncology therapies.

Reporting to a Senior Group Leader within the CDoT Translational Pharmacology team, you will play a key role in driving forward therapeutics projects within an exciting portfolio of novel immune-oncology targets. You will serve as a core therapeutics project team member, leading and executing development of cell-based and in vivo immune-oncology assays directly, while working with colleagues to implement these assays at scale and support screening activities to drive therapeutics programs. This role will afford the opportunity to apply your deep knowledge of cancer immunology and technical expertise in cell and molecular immunology to the development of novel therapies in collaboration with a dynamic set of academic and biopharmaceutical partners.

Responsibilities

• Lead development of cell-based and in vivo assays to support development of new immune-oncology therapies
• Execute experiments, interpret and validate results, and communicate findings to internal project teams, external collaborators, and strategic leadership teams
• Serve as a resource for collaborating scientists working within a portfolio of cancer immunology therapeutics projects

Skills & Abilities

• Deep knowledge of cell and molecular immunology, particularly cancer immunology
• Strong experimental background developing immune cell-based and in vivo assays
• Highly adaptable and responsive to technical and collaborative project needs; comfortable delivering against challenging commitments
• Outstanding verbal and written communication abilities; capable of conveying technical and strategic information in a clear and concise manner
• Confident, goal oriented, and highly collaborative; ability to adapt to and effectively manage change in fast paced and dynamic environments
• Previous industry experience with understanding of the drug discovery process from hit identification through late pre-clinical discovery is a plus
• A sense of urgency to find new medicines to benefit patients. 

Education & Experience

• PhD or equivalent in immunology, immune-oncology or a related field
• 2+ post-PhD years of relevant laboratory experience, in academic, pharmaceutical or biotechnology settings.
• Demonstrated ability in working in multi-disciplinary project teams in a fast-paced, matrixed environments.

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The Molecular Enzymology Division of New England Biolabs is inviting applications for a Research Scientist I who will be involved in the discovery and biochemical characterization of DNA and RNA base modifying enzymes. The successful applicant will employ chemical, kinetic, and analytical techniques to identify the function and study the mechanism of a variety of nucleic acid-related enzymes. Studies will be mainly focused but not limited to Fe(II)/2-oxoglutarte-dependent enzymes. Research will be undertaken in a highly collaborative and intellectually open environment where oral communication of ideas and publication of results are expected.

Primary Responsibilities:

• Develop in vivo and in vitro functional screening assays for a variety of enzymes such as DNA and RNA, Fe(II)/2-oxoglutarate-dependent, oxidizing enzymes, DNA decarboxylases, and base-hypermodifying enzymes.
• Express, purify, and biochemically characterize enzymes with novel chemistries.
• Perform mechanistic dissection of various enzymes using steady-state and transient-state kinetic tools.
• Perform binding studies using absorbance and fluorescence-based stopped-flow dependent methods.
• Collaborate with investigators at NEB and in academia.
• Communicate findings to the scientific community through publications and presentations.

Required Qualifications and Experience:

• Ph.D. in enzyme biochemistry, enzyme kinetics, or related field.
• Protein expression and purification skills.
• A strong foundation in enzyme kinetics including knowledge in steady-state and transient-state kinetics and kinetic simulation.
• A strong foundation in functional assay design.
• A strong foundation in chemistry.
• Strong analytical skills.
• Strong desire to learn new skills and to expand the scopes of the research through internal and external collaborative efforts.
• Strong record of scientific publication.
• Strong interpersonal skills.
• Excellent verbal and written communication skills.

Preferred Qualifications and Experience:

• Familiarity with analytical chemistry techniques such as HPLC and MS.
• Familiarity with Computational Biology tools.
• Desire to mentor summer and Master’s student interns.
• Personal drive to lead several projects in a technically challenging field.
• Willingness to learn and master new techniques

This position offers exciting opportunities for broad research training, collaboration with academic institutions, publishing in peer-reviewed journals and participation in national and international conferences.

How to Apply:

Apply on the NEB Jobs Website

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Research Scientist II in our Cambridge, MA office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission. APPLY HERE

POSITION ACCOUNTABILITIES:

• Seeking an Immunologist/ Cell Biologist with extensive in vitro/ cell-based assay experience to progress biologics and cell therapies programs
• Independently plan and implement experiments to deliver data for antibody/ cell therapy discovery and lead optimization
• Responsible for participating and interacting on matrix project teams with members of IO/GI/CNS/Rare Disease teams

CORE ELEMENTS RELATED TO THIS ROLE:

• Provide broad assay development support for early stage drug discovery projects in the field of Immuno-Oncology and GI/CNS/Rare Disease  
• Responsible for planning and executing in vitro immune cell functional assays. Initiate and develop new technologies
• Design, validate and execute high throughput cell-based assays to support biologics characterization and discovery
• Collaborate with automation engineers to identify suitable approaches to utilize laboratory automation for the execution of various cell-based assays
• Spends ~ 90% of time in laboratory to maintain and implement cell-based assay platform and perform experimental assays
• Interface with project teams to meet timelines for project progression
• Present research findings clearly and effectively at internal and external meetings
• Troubleshoot complex problems in creative and effective ways and actively participates in innovation and/or optimization of established processes to ensure delivery on project goals 

  EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:

• Ph.D. with 2-5 years or BSc/MS with 5-10 years relevant experience in Immunology/Cell Biology related field with experience in early stage pharmaceutical drug discovery
• Expert in T-cell , NK cell and other  immune cell biology and assay development
• Team player able to liaise across multiple disciples including Automation, Cell Biology and Immunology
• Self-motivated, collaborative with excellent time management and organizational skills
• Skilled in analysis, interpretation, and presentation of results
• Experience with  mammalian cell culture with best practices in tissue culture is required
• Hands on experience with automated platforms
• Excellent written and verbal communication skills, along with the ability to work in cross-functional project teams

WHAT TAKEDA CAN OFFER YOU:

• 401(k) with company match and Annual Retirement Contribution Plan
• Tuition reimbursement Company match of charitable contributions
• Health & Wellness programs including onsite flu shots and health screenings
• Generous time off for vacation and the option to purchase additional vacation days
• Community Outreach Programs