Fox Chase Cancer Center - Immunology Postdoctoral Position
An Immunology Postdoctoral Position in Philadelphia is available immediately in the lab of David Wiest at Fox Chase Cancer Center. My lab has a longstanding history of investigation into the molecular mechanisms controlling lymphoid development and transformation. We have the following exciting projects available:
- Analysis of the role on molecular control of gd T cell lineage commitment and effector fate, including the role of lncRNA, using genome wide approaches
- Investigation of the regulatory functions of ribosomal proteins in controlling hematopoietic development and transformation, with a particular focus on alterations in cell metabolism.
- Elucidation of novel domain-specific functions of ERK in cancer etiology and immunotherapy.
- Identification of novel regulators of lymphoid development by elucidating the molecular etiology of human immunodeficieny using zebrafish as a model.
In pursing these projects, we integrate mouse and zebrafish models with human data and samples and exploit genomic and proteomic approaches, as well as genome editing. Opportunities are available to learn not only how to perform wet “omic” analysis, but also how to perform the bioinformatic analysis necessary to maximally benefit from these approaches. Experience with mouse models and/or zebrafish is advantageous. Fox Chase is located in a safe suburban neighborhood with easy access to the city. More information about my research can be found at: https://www.foxchase.org/david-wiest. Please send CV and 3 references to David Wiest at: David.Wiest@FCCC.edu
Mount Sinai - Center for Eosinophilic Disorders Postdoctoral Fellow
This Postdoctoral Fellow position is in the Division of Allergy and Immunology, Department of Pediatrics at the Icahn School of Medicine at Mount Sinai. The Postdoctoral Fellow will will in conjunction with the Principal Investigator (Mirna Chehade, MD, MPH) at the Mount Sinai Center for Eosinophilic Disorders (MSCED), investigating the immunopathology of eosinophilic esophagitis (EoE).
We are seeking a highly motivated individual to work in the field of eosinophilic gastrointestinal disorders. The successful candidate will participate in a research project focused on the effect of proton pump inhibitors (PPI’s) on the esophageal transcriptome in EoE subtypes, and the role of various immune and signaling pathways in PPI-mediated suppression of esophageal eosinophilia. The candidate will be participating in an exciting journey intergrating in silico and wet Lab approaches to establish a new paradigm for translating gene expression profiles into mechanistic insights and eventually personalized precision patient care. In silico approaches including analyses of NGS data (including genome wide association studies, RNA sequencing (single cell and whole tissue)), bioinformatics strategies to study the genetic basis of EoE, and wet Lab assays including molecular analyses of primary esophageal cell culture systems, will be conducted.
The successful candidate must hold a PhD or equivalent degree with a background knowledge in immunology. Working knowledge of principles of immunology and molecular biology is required. The candidate must also demonstrate competency in RNA isolation from tissue/cells, RNAseq analysis and immunohistochemistry, as well as demonstrated experience in cell culture techniques, qRT-PCR, cytokine assays and flow cytometry. The candidate will have access to highly collaborative research teams with expertise in the required areas of research, including the Center for Bioinformatics and the Genomics Core and Pathology Core Facilities at the Icahn School of Medicine at Mount Sinai in New York City.
As the current MSCED team members have a strong clinical background and are all highly invested in research, the candidate will present data to the team. Ability to work autonomously with minimal supervision and collaboratively as part of the MSCED team, and ability to analyze and communicate experimental results clearly to other team members is required. Exceptional work ethic, strong written and verbal communication skills, strong organizational skills and ability to multi-task and prioritize are required for the position.
This is a unique opportunity to develop expertise in this growing area of EGIDs, which can serve as a platform for a potential future career as an independent research investigator at the MSCED.
The MSCED will provide the candidate with necessary support on all aspects of the project.
Full-time employment at Mount Sinai includes a competitive salary, medical/dental/vision benefits, paid vacation/sick leave, and employer contributions to a retirement plan (403b).
Interested candidates should include their full curriculum vitae, a cover letter briefly stating their career goals, specific research experience and areas of interest, and contact information of three references in their application, and send it to: MountSinaiEosCenter@mssm.edu
New England Biolabs - Molecular Enzymology Division Postdoctoral Fellowship
The Molecular Enzymology Division of New England Biolabs (NEB) is inviting applications for a Postdoctoral Fellow to conduct research on phage 5mC and T-hypermodifying enzymes. The successful applicant will employ high throughput in vivo and in vitro functional screening techniques to discover and biochemically characterize novel enzymes. Select enzymes with intriguing chemistries will undergo detailed kinetic characterization for more in-depth understanding of their modes of function. Research will be undertaken in a highly collaborative and intellectually open environment where publication of results is expected.
- Develop high throughput workflows using robotic handling systems for discovery of new 5-methylpyrimidine hypermodifying enzymes.
- Explore a variety of analytical methods such as LC-MS, LC-MS/MS, fluorescence, etc. for product detection.
- Elucidate pathways of 5-methypyrimidine hypermodification and reconstitute them in vitro.
- Express, purify, and kinetically characterize enzymes with novel chemistries.
- Collaborate with investigators at NEB and in academia.
- Communicate findings to the scientific community through publications and presentations.
- Ph.D. in enzyme biochemistry, natural products biosynthesis, synthetic chemistry, or related field
- Protein expression and purification skills.
- A strong foundation in enzyme chemical mechanisms.
- A strong foundation in functional assay design.
- A strong foundation in chemistry.
- Strong analytical skills.
- Strong record of scientific publication.
- Strong collaborative and interpersonal skills.
- Excellent verbal and written communication skills.
- Familiarity with techniques of analytical chemistry such as HPLC, MS, and fluorescence.
- Familiarity with steady-state and transient-state kinetics.
- Experience in Synthetic Chemistry.
- Desire to gain experience on robotic handling systems.
- Personal drive to lead a project in a technically challenging field.
- Willingness to learn and master new techniques
This position offers exciting opportunities for broad research training, collaboration with academic institutions, publishing in peer-reviewed journals and participation in national and international conferences.
How to Apply
NIAMS - Autoimmunity and Inflammation Postdoctoral Fellowship
A postdoctoral position is available in the The group focuses in characterizing mechanisms that lead to immune dysregulation, loss of immunologic tolerance and end organ damage in systemic autoimmune diseases such as systemic lupus erythematosus. The successful candidate will employ innovative approaches to understand how the innate immune system contributes to the development of autoimmune disorders, integrating use of human and murine systems with omics technologies and functional studies.
We seek highly motivated, collaborative and creative individuals with MD, PhD or MD PhD and less than 5 years of postdoctoral experience. Previous experience in cellular/ molecular biology, systems biology analysis and/or animal models of disease is desirable. The candidate should have excellent writing and communication skills.
Please send a research statement, CV and names and contact information of 3 professional references to :
Mariana Kaplan, MD
Systemic Autoimmunity Branch, NIAMS
University of Illinois at Chicago - Department of Microbiology and Immunology Postdoctoral Associate
The laboratory of Dr. Marlene Bouvier in the Department of Microbiology and Immunology of UIC has an immediate opening for a Research Scientist or Postdoctoral Associate, based on number of years of research experience after PhD, to play an active role in our ongoing studies of immune evasion mechanisms involving Adenovirus and immune cell surface receptors. We are seeking a highly motivated and intellectually curious individual with a rigorous training in virology/immunology and advanced hands on experience in molecular biology and other techniques such as generation of virus stocks, determination of virus titers, acquisition and analysis of flow cytometry data, quantitative PCR, cell-based and biochemical assays, electrophoresis techniques, and maintenance of mammalian cells. The selected candidate will have the opportunity to gain knowledge in structural virology/immunology.
For immediate consideration, please submit a cover letter to firstname.lastname@example.org and complete resume.
Cleveland Clinic - Immunology and Sex Steroids Postdoctoral Fellowship
Do you have a background in immunology and are interested in translational medicine? If so, a postdoctoral fellowship position is available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic.
We recently discovered the genetic basis for sex steroid metabolism that regulates distinct clinical immune and inflammatory response in humans (Zein, et al. PNAS. 2020; 117(4) 2187-2193). The steroid metabolism
consequences on androgen synthesis is something our group has worked out in great detail (Chang, et al. Cell. 2013;154:1074-84; Hearn, et al. Lancet Oncol. 2016;17:1435-44; JAMA Oncol. 2018;4:558-62). We have
discovered steroid metabolism drivers that dictate a general mechanism of human physiology that impinges on multiple pathophysiologic disease processes.
We are searching for an incisive and highly driven postdoctoral fellow in immunology to dissect the mechanisms by which specific downstream sex steroids (i.e., androgens and estrogens) conduct the immune response.
The fellow will be embedded in a unique and multidisciplinary environment with exposure to tumor metabolism, molecular oncology, endocrine physiology, drug development and clinical trials. Further details are available at:
The ideal candidate has a Ph.D. degree in immunology or molecular immunology and is highly driven. Outstanding verbal and communication skills are required. Interested candidates should send their CV and contact
information for 3 references to:
Nima Sharifi, M.D.
Kendrick Family Chair for Prostate Cancer Research
Director, GU Malignancies Research Center
University of Pennsylvania - Babushok Lab Postdoctoral Fellow Position
Daria Babushok, MD PhD
Assistant Professor of Medicine
Division of Hematology-Oncology, Abramson Cancer Center
Perelman School of Medicine at the University of Pennsylvania
Member of Penn Immunology and Cell and Molecular Biology Graduate Groups
The Babushok Laboratory at the University of Pennsylvania aims to understand the underlying mechanisms of autoimmune bone marrow failure disease called aplastic anemia and to elucidate drivers of pre-malignant clonal evolution in bone marrow failure disorders. The long-term goal of the laboratory is to translate the improved understanding of the pathogenesis of aplastic anemia and related bone marrow failure disorders into better patient outcomes through more precise diagnostics and rationally-designed, more effective therapies. The laboratory seeks a creative and motivated Postdoctoral Fellow to join our team to study the mechanisms of autoimmunity and immune evasion in aplastic anemia and related disorders.
Highly motivated candidates with a recent or shortly anticipated Ph.D. and a record of accomplishment (e.g., one or more first-author research publications) in an immunology-related field are encouraged to apply. Experience with mouse models is preferred. The candidate must be able to work independently and collaboratively within a larger research team. The candidate must have excellent analytical skills, be a creative thinker, be able to learn and troubleshoot new techniques, maintain accurate research records, and have excellent personal and communication skills.
Commensurate with experience and according to the NIH guidelines.
How to Apply:
Candidates should send inquiries including a CV, contact information for three references, and a brief (less than 1 page) statement describing their research background and interests to email@example.com