Dr. Keshamouni is an Associate Professor of Medicine, in the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan. Research biologist, Ann Arbor VA Medical Center. Dr. Keshamouni obtained his Master’s (Biochemistry) from Osmania University, and Ph.D (Plant Photobiology) from University of Hyderabad, Hyderabad, India. Moved to United States, completed postdoctoral training at Indiana University, Wayne State University and University of Michigan. Started his own laboratory at University of Michigan in 2008 investigating cellular and molecular interactions in lung tumor microenvironment. He was named Parker B Francis Fellow, received American Cancer Society Research Scholar Award and American Lung Association Lung Cancer Discovery Award. He serves on several grant review committees of public and private foundations in US and Europe. He is the member of both Cancer Biology and Immunology graduate programs.
Dr. Keshamouni’s group is broadly interested in deciphering cellular and molecular interactions in the tumor microenvironment (TME) that contribute to tumor growth and metastasis. Areas under investigation are a) innate immune surveillance mechanisms mediated by NK cells, macrophages, complement system and TLR signaling, b) Engineering NK cells with chimeric antigen receptors for lung cancer therapy, and c) restoring tumor suppressive mechanisms of the cytokine TGF-beta, a master regulator of tumor-stromal interactions in the TME.