Assistant Professor, Department of Internal Medicine
Assistant Professor, Department of Molecular & Integrative Physiology
Laboratory Research Program
Contraction of the heart is triggered by an electrical impulse, which is normally initiated in the pacemaker region of the heart known as the sinus node. The cardiac electrical impulse is the result of an orchestrated action of several protein macromolecules known as ion channels. The channel proteins are, in a sense, molecular machines that translocate ions (e.g., Na+, K+ and Ca++) across the membrane of each heart cell. Properties of an ion channel depend on its three-dimensional structure as well as on the interactions of the channel protein with other (accessory) proteins in specific micro-domains of the cell. A number of cardiac rhythm disturbances have been associated with mutant ion channel proteins, accessory proteins to the ion channels, or the improper interactions between the two groups of proteins. We are interested in understanding the cellular and molecular bases for these rhythm abnormalities. In the laboratory, we use a combination of electrophysiological, biochemical and molecular biological techniques to carry out our investigations.
Dr. Anumonwo's publications are listed on PubMed.