Research Funding

  • Over $10 million dollars in active funding (2017–2018) and over $21 million in funding over the last 5 years (2013–2018)
  • The funding described for each condition represents a subset of the activities at Michigan Medicine.

Acute Pancreatitis

  • NIH R21 DK106647 (DiMagno PI): Acute Pancreatitis Alert & Decision Support Improves Care & Cuts Length of Stay.
    This study tests the hypothesis that use of the second generation quality improvement tool (The AP Early Response (TAPER)-Clinical Decision Support (CDS)-Tool) will further increase compliance with accepted clinical guidelines, improve clinical outcomes, and lower hospitalization costs for AP patients.
  • University of Michigan Translational Research and Commercialization Kickstart Award (DiMagno PI): An Electronic Alert Instrument Shortens Hospital Length of Stay in Acute Pancreatitis.
    This pre-implementation study focuses on improving clinical workflow and increasing use of The AP Early Response (TAPER) Clinical Decision Support (CDS) Tool by integrating the Tool into the electronic medical record as one locus for alerting clinicians to the diagnosis of acute pancreatitis, providing automated specific patient information and creating a web link to the TAPER-CDS-Tool.
  • NIH U34 DK09984 01 (Elmunzer PI): Stent vs Indomethacin for Preventing Post-ERCP Pancreatitis (SVI Study)
    The study aim is to establish the infrastructure necessary to conduct the multi-center clinical study necessary to determine, in a scientifically rigorous fashion, whether indomethacin can replace pancreatic stent placement for preventing post-ERCP pancreatitis in high-risk patients, leading to improved clinical outcomes and reduced costs.
  • NIH 7 R01 CA 159222 05 (Crawford-PI): ADAM17 in Pancreatic Cancer and Pancreatitis.
    The study aim is to define the mechanisms by which ADAM17 contributes to these diseases and to assess the potential for designing therapies targeting ADAM17 and the pathways it regulates for treating pancreatic cancer and pancreatitis.
  • 5R01CA151588-04 (Pasca Di Magliano PI): GLI Activity in the Pancreas: Inflammation, Tissue Repair and Cancer
    The study aim is to understand how the Hedgehog signaling pathway promotes pancreatic carcinogenesis, and whether it would constitute a promising therapeutic target for this disease.

Chronic Pancreatitis

  • NIH R21 AA017271 (DiMagno PI); Pioglitazone therapy for endocrine and exocrine disease in alcoholic pancreatitis.
    This study tests the hypothesis that pioglitazone improves pancreatic endocrine and exocrine function and structure and quality of life and reduce pain.
  • NIH 1 R01 DK 110436 01 (Owyang PI); Modulation of Visceral Hypersensitivity in IBS by Lipid Mediators
    The aim of the study is to identify pro- and anti-inflammatory molecules that can modify the electrophysiological properties of sensory neurons of IBS patient and to define the signal transduction mechanisms responsible for these changes. Results from the study may provide therapeutic targets to reduce pain in IBS patients (and other gastrointestinal conditions associated with pain).

Exocrine Pancreatic Insufficiency

  • NIH 5 R01 DK 059578 10 (Williams PI): Dietary regulation of pancreatic digestive enzymes
    The study aim is to design approaches to assist the human pancreas to regenerate and ensure an adequate supply of pancreatic digestive enzymes
  • NIH 5 R37 DK 041122 22 (Williams PI): Calcium and pancreatic stimulus-secretion coupling
    The study aim is to understand the proteins involved in normal digestive enzyme secretion

Cystic Fibrosis

  • Cystic Fibrosis Foundation (DiMagno PI): Developing Innovative GastroEnterology Specialty Training (DIGEST) award.
    This grant supports physicians interested in developing expertise in the gastroenterologic care of patients with CF.
  • NIH DK073298 (DiMagno PI): KO8 Mentored Clinical Scientist Development Award, entitled, Inflammatory response to pancreatitis in CF mice: sodium & impaired apoptosis.
    This study uses experimental models to investigate mechanisms for recurrent acute pancreatitis in humans with CFTR gene mutations.

Pancreatic Cysts

  • NIH U10 CA086402 (Brand PI, Kwon Site-PI): Pancreatic Cystic Reference Set.
    This grant seeks to build a repository of samples and data from pancreatic cyst patients
  • Covidien Pilot Awd in Technology (Kwon PI) AGA Research Foundation: Analytic morphomics for patients with pancreatic cysts.
    This grant tests the hypothesis that utilizing analytic morphomics technology on CT scans will improve the capability of cross sectional imaging to distinguish mucinous and non-mucinous cysts.

Pancreatic Cancer

  • NIH 5 R21 CA 167122 02 (Allen / Pasca Di Magliano PI): Novel Hedgehog Receptors as Therapeutic Targets in Pancreatic Cancer
    The study aim is to systematically evaluate the function of three novel Hedgehog (Hh) co-receptors that play a role in Hh ligand driven pancreatic cancer, with the goal of developing compounds that target these novel Hh receptors as an alternative approach to treat cancer.
  • NIH 1 R01 CA 198074 01 (Allen / Pasca Di Magliano PI): Dosage-Dependent Hedgehog Signaling in Pancreatic Cancer
    The study aim is to evaluate the mechanisms for an unexpected dose-dependent role of Hedgehog (Hh) signaling in pancreatic tumorgenesis, with the goal of developing alternative approaches to treat cancer.
  • NIH 1 U01 CA 224145 01 (Crawford PI): Interrupting Cellular Crosstalk in the Immunosuppressive Microenvironment of Pancreas Cancer
    The study aim is to use multiple unique preclinical models to disrupt the multicellular crosstalk that establishes the immunosuppressive microenvironment of pancreatic cancer, thereby enhancing immunotherapeutic responses for cancer treatment
  • NIH K23 DK082097 (PI: Anderson): Validation Study of Select Biomarkers for the Diagnosis of Pancreatic Cancer
    This study seeks to determine whether a select panel of biomarkers can detect pancreatic neoplasia at an early stage.
  • Lefkofsky Family Foundation Scholar Award (Lyssiotis PI): Defining and Exploiting Metabolic Dependencies in Pancreatic Cancer
    The study aim is to define and test new metabolic drug targets in pancreatic cancer
  • Dale F. Frey Award for Breakthrough Scientists, Damon Runyon Foundation (Lyssiotis PI): Defining and Exploiting Metabolic Dependencies in Pancreatic Cancer
    The study aim is to define and test new metabolic drug targets in pancreatic cancer

Other Pancreatic Research

  • NIH 1 G13 LM 010912 01 A1 (Williams PI): Implementation of a pancreas knowledgebase
    This proposal aims to develop and maintain a centralized electronic resource on pancreatic research to facilitate the sharing of information among researchers and the general public on the latest developments in this critical area that affects the health of a large number of people in this country.
  • NIH 1 T32 DK 094775 01 (Owyang PI): Training in basic and translational digestive sciences
    This proposal puts together a training program which consolidates the major investigators conducting gastrointestinal research at the University of Michigan into a strong core of mentors to address this unmet need. Support is requested for 4 postdoctoral trainees and 4 predoctoral candidates selected from the University of Michigan program in biological sciences
  • NIH 5 P30 DK 034933 28 (Owyang PI) University of Michigan Gastrointestinal Peptide Research Center
    Gl peptides function not only as classical hormones, but also as neurotransmitters, growth factors and cytokines. This study aims to examine the roles of peptides in the pathophysiology and treatment of Gl disorders