AASLD

2021 AASLD

The American Association for the Study of Liver Diseases (AASLD) is the leading organization of scientists and health care professionals committed to preventing and curing liver disease.

Please see a daily compilation of the main sessions during which our faculty, fellows, and researchers are presenting at The Liver Meeting Digital Experience, November 12–15, 2021.

Please check back often. Updates will be made as they are received.

AASLD Research Awards

AASLD Foundation Advanced/Transplant Hepatology Award

Karn Wijarnpreecha, MD, MPH
Incidence of cirrhosis and extrahepatic manifestations in lean individuals with nonalcoholic fatty liver disease
Mentor: Anna S. Lok, MD, FAASLD

Leadership Positions

AASLD Committees, Special Interest Groups (SIGs), Journal Editorial Boards

Patricia P. Bloom, MD
Communications and Technology Committee

Trainee Member

Robert Fontana, MD, FAASLD
Hepatology
Editorial Board
Hepatology Communications
Editorial Board

Anna S. Lok, MD, FAASLD
Hepatitis B

Steering Committee
Hepatology
Editorial Board

Jessica L. Mellinger, MD, MSc
Practice Guidelines Committee

Member
Clinical Liver Disease
Associate Editor
Hepatology Communications
Editorial Board
Liver Transplantation
Editorial Board

Neehar D. Parikh, MD, MS
Practice Metrics Committee
Member
Liver Transplantation
Editorial Board

Nataliya Razumilava, MD
Continuing Medical Education Committee
Member

Pratima Sharma, MD, MS
Public Policy Committee
Member
Acute on Chronic Liver Failure
Steering Committee
Liver Transplantation and Surgery
Steering Committee
Liver Transplantation
Associate Editor

Grace L. Su, MD, FAASLD
AASLD 2021 Governing Board

Councilor
AASLD Executive Committee
Clinical Research Committee
Board Liaison
Continuing Medical Education Committee
Board Liaison
Maintenance of Certification Committee
Board Liaison
Membership and Mentorship Committee
Board Liaison

Elliott B. Tapper, MD
Practice Metrics Committee
Chair-Elect
Cirrhosis Quality Collaborative
Hepatology
Editorial Board
Hepatology Communications
Editorial Board
Liver Transplantation
Editorial Board

The Liver Meeting Program - Chairs, Moderators

Saturday, November 13, 2021

Parallel Session 4: COVID-19 Clinical
1:00 pm – 2:30 pm
Moderator: Robert Fontana, MD, FAASLD 

Sunday, November 14, 2021

Late Breaking Session 1
1:00 pm – 2:30 pm
Moderator: Grace L. Su, MD, FAASLD

COVID-19 and the Liver Symposium
7:00 pm – 8:30 pm
Program Chair: Robert Fontana, MD, FAASLD 

Monday, November 15, 2021

Parallel Session 30: Genomics and Precision Medicine
12:30 pm – 2:00 pm
Moderator: Vincent Chen, MD

Invited Speakers

Friday, November 12, 2021

Hepatitis B SIG

11:30 am – 1:00 pm

Novel biomarker – Advances in disease outcome and HBV cure prediction
Anna S. Lok, MD, FAASLD

Public Health / Health Care Delivery SIG

5:30 – 7:00 pm

Behavior management of alcohol-related liver disease (ALD
Jessica L. Mellinger, MD, MSc

Monday, November 15, 2021

Emerging Trends Symposium

10:00 – 11:30 am

NAFLD pathophysiological subtypes: Insights from human genetics
Elizabeth K. Speliotes, MD, PhD, MPH

Pre-Events, Debates, Meet the Experts, Workshops

Pre-event Sessions

Pre-event sessions will launch on Monday, November 8, 2021.

AASLD/ASGE Endoscopy Course

Clinical Challenges and Practical Solutions at the Interface of Liver Disease and Endoscopy

6:00 – 11:25 am

Allison Schulman, MD, MPH

General Hepatology Update

6:00 – 7:30 am

Title of talk TBD
Jessica L. Mellinger, MD, MSc

Value-based Medicine in Hepatology

6:00 – 7:30 am

Title of talk TBD
Elliot B. Tapper, MD

Friday, November 12, 2021

Career Development Workshop

3:00 – 4:30 pm

Elliot B Tapper, MD

AASLD 2021 Academic Debates

7:00 – 8:30 pm

Anuhya Gampa, Matthew Odenwald, Jasleen Singh, Sentia Iriana, Kara Wegermann, Jacqueline Henson, Jason Pan, Abhishek Shenoy

Sunday, November 14, 2021

Basic Research Workshop - Part I (From Liver Phenotype to Gene Discovery)

10:00 – 11:30 am

Elizabeth K. Speliotes, MD, PhD, MPH

Monday, November 15, 2021

Meet the Expert

9:00–10:00 am

Patricia P. Bloom, MD
The role of the microbiome in the pathophysiology of portal hypertension and its complications

Parallel Sessions - Oral Abstract Presentations

Saturday, November 13, 2021

Parallel Session 6: Experimental and Translational Portal Hypertension and ACLF
6:30 – 8:00 pm

Abstract #50
Clustered molecular responses to hyperammonemia mediate sarcopenia in cirrhosis with accelerated skeletal muscle senescence
Nicole Welch, Shashi Shekhar Singh, Avinash Kumar, Saugato Rahman Dhruba, Saurabh Mishra, Jinendiran Sekar, Annette Bellar, Amy Attaway, Aruna Kumar Chelluboyina, Belinda Willard, Ling Li, Zhiguang Huo, Sadashiva S. Karnik, Karyn Esser, Michelle Longworth, Yatrik Shah, Gangarao Davuluri, Ranadip Pal, Srinivasan Dasarathy

Parallel Session 8: HBV cascade of care, natural history and diagnostics
6.30–8.00 pm

Abstract #65
Role of HBV RNA and hepatitis B core-related antigen in predicting sustained inactive carrier phase in chronic hepatitis B
Marc G. Ghany, Wendy C. King, Anna S.F. Lok, Norah Terrault, Harry L.A. Janssen, Raymond T. Chung, Mauricio Lisker-Melman, Amanda S. Hinerman, Mandana Khalili, William M. Lee, Daryl T.Y. Lau, Gavin A. Cloherty, Richard K. Sterling, and the HBRN

Parallel Session 9: COVID-19 Translational and Clinical
6:30 – 8:00 pm

Abstract #71
Long-term clinical outcomes of patients with COVID-19 and chronic liver disease: US multicenter study cold study
Elizabeth Aby, Jenna L Gustafson, Michael Daidone, Raymond T Chung, Sunny Sandhu, Aalam Sohal, Sameeha Khalid, Marina Roytman, Lee Varelas, Akshata Moghe, Ghady Moafa, Nyan L Latt, Rotonya M Carr, Yedidya Saiman, Andreea M Catana, Ihab Kassab, Vincent Chen, Carly Rosenberg, Jose D. Debes, Atoosa Rabiee, Veronica Nguyen, Christina Gainey, Kali Zhou, Kenneth D. Chavin, Blanca Lizaola-Mayo, Sonal Kumar, Renumathy Dhanasekaran

Sunday, November 14, 2021

Parallel Session 11: Healthcare Quality and Access in Hepatology
10:00 – 11:30 am

Abstract #84
The SCAN-ECHO force multiplier effect builds primary care provider capacity through virtual consultations to improve survival for veterans living with liver disease
Ponni V. Perumalswami, Kyle Kumbier, Bradley Youles, Patrick Belancourt, Sameer Saini, Grace L. Su

Parallel Session 19: Clinical Advances in Alcohol-Associated Liver Disease
4:00 – 5:30 pm

Abstract #129
Polygenic risk scores improve identification of individuals at increased risk of alcohol-related liver disease, above alcohol intake alone
Kelly Cushing, Xiaomeng Du, Yanhua Chen, Lc Stetson, Annapurna Kuppa, Elizabeth K. Speliotes

Parallel Session 20: Hepatobiliary Neoplasia: Clinical Oral Session
4:00 – 5:30 pm

Abstract #138
GALAD score improves early detection of HCC prior to the diagnosis of HCC: A phase 3 biomarker validation study
Jorge A. Marrero, Tracey L Marsh, Neehar D. Parikh, Lewis R. Roberts, Myron E Schwartz, Mindie H. Nguyen, Alex Befeler, Stephanie Page-Lester, Jeffrey Winick, Mara Vecchio, Paul Wagner, Sudhir Srivastava, Jo Ann Rinaudo, Amit G. Singal, Ziding Feng, K Rajender Reddy

Monday, November 15, 2021

Parallel Session 27: Diversity, Equity, and Inclusion in Liver Disease Care
10:00 – 11:30 am

Abstract #179
Trends in the inpatient burden of alcohol related liver disease among women hospitalized in the United States
Madeline Bertha, Kerby Shedden, Jessica L. Mellinger

Parallel Session 30: Genomics and Precision Medicine
12:30 – 2:00 pm

Abstract #196
A blood-based prognostic liver secretome signature predictive of long-term HCC risk to guide chemopreventive intervention in advanced liver fibrosis
Naoto Fujiwara, Masahiro Kobayashi, Austin J Fobar, Cesia A Marquez, Bhuvaneswari Koneru, Tongqi Qian, Indu Raman, Quan-Zhen Li, Hitomi Sezaki, Hiromitsu Kumada, Ryosuke Tateishi, Takeshi Yokoo, Adam C Yopp, Raymond T Chung, Bryan C Fuchs, Thomas F. Baumert, Jorge A. Marrero, Neehar D. Parikh, Shijia Zhu, Amit G. Singal, Yujin Hoshida

Posters

Acute Liver Failure and Artificial Liver Support: Acute Liver Failure and Artificial Liver Support

Abstract #248
Outcomes in idiosyncratic drug induced acute liver failure (DILI-ALF) are improving over time
Ashwin Rao, Jody A. Rule, Bilal Hameed, Daniel R. Ganger, Robert J. Fontana, William M. Lee

Alcohol-Associated Liver Diseases: Clinical and Experimental

Abstract #309
Behavior markers in alcohol-related liver disease: Risk perception associates with treatment utilization and abstinence duration
Jessica L. Mellinger, Lara Coughlin, Gerald Winder, Anne Fernandez, Frederic C Blow, Brian Zikmund-Fisher, Anna S. Lok

Biliary Physiology, Transport, Cholangiocyte Biology, Experimental Cholestasis: Cholangiocyte Biology

AASLD Presidential Poster of Distinction
Abstract #421
Extrahepatic bile duct hedgehog signaling regulates CXCL1 recruitment of inflammatory cells to induce proliferation after acute injury
Nureen Hanisah Mohamad Zaki, Junya Shiota, Theresa Keeley, Kazuhiko Nakao, Linda C Samuelson, Nataliya Razumilava

COVID-19 and the Liver - Health Services

AASLD Presidential Poster of Distinction
Abstract #532
Increased alcohol consumption during COVID-19 pandemic is projected to increase alcohol-related  liver disease: A modeling study
Jovan Julien, Turgay Ayer, Carolina Barbosa, William Dowd, Elliot B Tapper, Jag Chhatwal

Genomics and Precision Medicine

Abstract #564
Dietary effects on hepatic steatosis are amplified by genetic risk
Vincent L. Chen, Xiaomeng Du, Yanhua Chen, Annapurna Kuppa, Brian Halligan, Elizabeth K Speliotes

Gut Liver Axis and Microbiome

AASLD Presidential Poster of Distinction
Abstract #594
Microbiota may be linked to increased intestinal permeability in cirrhosis
Patricia Bloom, Shi-Yi Zhou, Christine Bassis, Chung Owyang, Vincent Young, Anna Lok

Health Services and Public Health Research: Health Care Delivery/Access/Quality

Abstract #605
An open access hepatitis C virus case consulting program to expand frontline community provider capacity
Ponni V. Perumalswami, Robert McMorrow, Kaylyn Curtis, Erin Wright, Audrey Hazelbaker, Mary F Myrick, Maureen Mead, Lynsie Stepanski, Dan Oliver, Miranda Jackson, Andrea Daoust, Timothy Shewcraft, Allison Lin, Amy Bohnert, Brandon Harkonen, Sheba Sethi, Anna S. Lok

Abstract #644
Inadequate health literacy is associated with lower rates of hepatocellular carcinoma surveillance in patients with cirrhosis
Kerry Lindquist, Elliot B Tapper, Brooke Wyatt, Amanda Marshall, Pratima Sharma, Alan Wilson, Matoumba M. Claiborne, Marie-Louise Holiday, Andrew W. Tai, Heather McCurdy, Grace L. Su, Ponni V. Perumalswami

Abstract #660
Practical barriers to telehealth visits in hepatology
Chip Bowman-Zamora, Ponni V. Perumalswami, Lon Kai Pang, Patricia Thai, Kaiyi Jiang, Zhuoran Yao, Shawn Fan, Cynthia Chen, Robert Chen, Sabia Abidi, Gary Woods, Costica Aloman, John R Treichler, Andrea D. Branch

Health Services and Public Health Research: Patient Centered Outcomes Research

Abstract #657
Patient portal use is associated with lower 90-day readmissions in decompensated cirrhosis
Jeremy Louissaint, Jeffrey Gibbs, Abhishek Shenoy, Anna S. Lok, Elliot B Tapper

Health Services and Public Health Research: Social Determinants of Health/Disparities/Equity

Abstract #669
Social determinants of health and racial disparities in alcohol treatment utilization for alcohol-related cirrhosis patients
Jessica L. Mellinger, Kerby Shedden

Hepatitis B: Epidemiology, Prevention, Natural History

Abstract #732
Characteristics of older patients with immunotolerant chronic hepatitis B virus infection in the Hepatitis B Research Network (HBRN) adult cohort
Jordan J. Feld, Wendy King, Marc G. Ghany, Kyong-Mi Chang, Norah Terrault, Robert P. Perrillo, Amanda Hinerman, Harry L.A. Janssen, Anna S. Lok, and the Hepatitis B Research Network (HBRN)

Abstract #756
Optimizing hepatitis B virus screening in the United States using a simple demographics-based model
Nathan Ramrakhiani, Vincent Chen, Michael Le, Yee Hui Yeo, Scott D. Barnett, Akbar Waljee, Ji Zhu, Mindie H. Nguyen

Hepatitis B: Therapeutics: Approved Agents

Abstract #783
Effects of HBV subgenotype A2 and an initial 24-week course of peginterferon on outcomes with longer-term tenofovir: The multicenter HBRN Immune Active (IA) trial
Norah Terrault, Anna S. Lok, Abdus Wahed, Marc G. Ghany, Robert P. Perrillo, David Kh Wong, Mandana Khalili, Daryl Lau, Richard K. Sterling, Adrian M Di Bisceglie, Mauricio Lisker-Melman, Stewart Cooper, Raymond T Chung, Keyur Patel, Lewis R. Roberts, Charles Landis, Christopher A. Aoki, Mohamed A. Hassan, Steve Belle, Jay H. Hoofnagle, Harry L.A. Janssen, and the Hepatitis B Research Network

Abstract #811
Symptoms of liver disease during tenofovir therapy with or without peginterferon: Results from the Hepatitis B Research Network Immune Active Trial
Donna M. Evon, Hsing-Hua Lin, Abdus Wahed, Mandana Khalili, Robert J. Fontana, Jay H. Hoofnagle, Hepatitis B Research Network

Abstract #816
The relationship between ALT flares and HBV antigen kinetics during treatment with tenofovir monotherapy or peginterferon plus tenofovir
Robert Perrillo, Anna S Lok, Kelsey Leonard, Marc G. Ghany, Norah Terrault, Steven H. Belle, Harry LA Janssen for the Hepatitis B Research Network

Abstract #817
Treatment withdrawal after long-term nucleotide analogue therapy with or without peginterferon: Predictors of ALT flares, HBsAg decline and active disease
Jordan J. Feld, Abdus Wahed, Marc G. Ghany, Mandana Khalili, Norah Terrault, Robert P. Perrillo, Adrian M Di Bisceglie, Michael W. Fried, Steve Belle, Harry L.A. Janssen, Anna S. Lok, Hepatitis B Research Network (HBRN)

Hepatobiliary Neoplasia: Clinical: Hepatocellular Carcinoma and Cholangiocarcinoma

AASLD Presidential Poster of Distinction
Abstract #1011
Barriers to HCC surveillance in a multicenter US cohort
Neehar D. Parikh, Nabihah Tayob, Taim Al-Jarrah, Jennifer Kramer, Jennifer Melcher, Donna L Smith, Patrick Marquadt, Po-Hong Liu, Nicole E. Rich, Fasiha Kanwal, Amit G. Singal

Abstract #1035
Design and implementation of a best practice advisory in electronic medical records for hepatocellular carcinoma surveillance
Neehar D. Parikh, Cheryl Dehmlow, Tammy Ellies, Anna S. Lok

Abstract #1103
Risk of progression to hepatocellular carcinoma in patients with indeterminate (LI-RADS 3) liver observations
Ashwini Arvind, Sagar Joshi, Timothy Zaki, Daniel A Burkholder, Takeshi Yokoo, David Fetzer, Travis Browning, Nicole E. Rich, Jorge A. Marrero, Adam C Yopp, Purva Gopal, Neehar D. Parikh, Amit G. Singal

Hepatobiliary Neoplasia: Diagnostics and Liver Imaging

Abstract #1169
Multimodal machine learning models combining clinical and quantitative imaging features can predict HCC in indeterminate LI-RADS 3 and 4 lesions in cirrhosis patients
Peng Zhang, Nicholas Wang, Sven Holcombe, Anum Aslam, Neehar D. Parikh, Emily Harding-Theobald, Amit G. Singal, Anna S. Lok, Stewart Wang, Issac R Francis, Grace L. Su

Abstract #1170
Natural history of sub-centimeter liver lesions on abdominal ultrasound
Samuel Phen, Jonathan Melendez-Torres, Nicole E. Rich, Sruthi Yekkaluri, Travis Browning, David Fetzer, Takeshi, Yokoo, Neehar D. Parikh, Amit G. Singal

Hepatotoxicity: Drug Metabolism, Toxicity, and Therapeutics

Abstract #1199
Characteristics of liver injury in antiepileptic drugs (AEDs) in the United States: Results from the DILIN Prospective Study
Naga P. Chalasani, Jonathan G Stine, Herbert L Bonkovsky, Huiman Barnhart, David E Kleiner, Robert J. Fontana, Jay H. Hoofnagle

Abstract #1215
Methylprednisolone associated drug-induced liver injury
Jawad Ahmad, Yi-Ju Li, Huiman Barnhart, Elizabeth J. Phillips, Paul H. Hayashi, Naga P. Chalasani, Robert J. Fontana, David E Kleiner, Jay H. Hoofnagle

Abstract #1234
Vancomycin induced liver injury, DRESS, and HLA-A*32:01
Bilal Asif, Christopher Koh, Huiman Barnhart, Naga P. Chalasani, Robert J. Fontana, Paul H. Hayashi, Victor J. Navarro, Elizabeth J. Phillips, Jay H. Hoofnagle, and the Drug Induced Liver Injury Network

Hepatotoxicity - Predictors of Drug Toxicity

Abstract #1200
Clinical features of sulfonamide hepatotoxicity significantly vary by patient age: Results from the DILIN Prospective Study
Robert J. Fontana, Naga P. Chalasani, Jiezhun Gu, David E Kleiner, Herbert L Bonkovsky, Huiman Barnhart, Jay H. Hoofnagle

Abstract #1214
Liver injury in patients receiving durvalumab is associated with increased mortality but infrequently attributed to the drug
Ihab A Kassab, Linnea Swanson, Irene Tsung, Robert J. Fontana

Abstract #1225
Secular trends in the etiologies and outcomes of patients with idiosyncratic DILI in the United States: Results from the DILIN Prospective Study
Robert J. Fontana, Huiman Barnhart, Naga Chalasani, Paul Watkins, David Kleiner, Joe Odin, Andrew Stolz, Victor Navarro, Jose Serrano, Sherry Gu, Jay Hoofnagle

Abstract #1230
The role of chemical analysis in causality assessment of herbal and dietary supplement (HDS) induced liver injury
Ashley Davis, Victor J. Navarro, Jawad Ahmad, Bharathi Avula, Huiman Barnhart, A. Sidney Barritt IV, Herbert L Bonkovsky, Vincent Chen, Gina Choi, Robert J. Fontana, Marwan S. Ghabril, Paul H. Hayashi, Ikhlas Khan, Christopher Koh, Joseph Odin, Don C. Rockey, Simona Rossi, Hoss Rostami, Leonard B. Seeff, Jose Serrano, Averell H. Sherker, Andrew Stolz, Hans L. Tillmann, Raj Vuppalanchi

Liver Transplantation and Liver Surgery: Donor And Allocation Issues, Living Donor and Split Liver Transplantation, and Hepatobiliary Surgery

Abstract #1430
Impact of new simultaneous liver kidney allocation policy on post liver transplant outcomes and number of kidneys used
Muhammad Waleed, Muhammad Hassaan Arif Maan, Yong-Fang Kuo, Paul Yien Kwo, Nadim Mahmud, Pratima Sharma, Mitra K. Nadim, Ashwani K. Singal

Liver Transplantation and Liver Surgery: Immunosuppression, Outcomes, and Complications

Abstract #1470
Cardiac positron emission tomography myocardial perfusion imaging (PET MPI) findings predictive of post-transplant major adverse cardiac events
Dempsey L. Hughes, Adeline Answine, Kirby Shedden, Monica A. Tincopa, Christopher J. Sonnenday, Sathish Kumar, Robert J. Fontana, Pratima Sharma

NAFLD and NASH: Epidemiology and Natural History, Prevention and Outcomes

AASLD Presidential Poster of Distinction
Abstract #1693
Heterogeneity in risk for advanced disease among NAFLD patients across the age spectrum
Matthew J Miller, Emily Harding-Theobald, Jacob V DiBattista, Daniel Burkholder, Vincent Chen

Abstract #1710
Metabolic abnormalities, liver and body fat in American versus Chinese patients with non-alcoholic fatty liver disease
Wei Zhang, Grace L. Su, Sravanthi Kaza, Rui Huang, Yi Wang, Huiying Rao, Lai Wei, Anna S. Lok

AASLD Presidential Poster of Distinction
Abstract #1724
Prevalence of high liver stiffness and a screening strategy via SODA-2B score among US adults
Sebastian Niezen, Elliot B Tapper, Hirsh Trivedi, Michelle Lai, Michael P. Curry, Kenneth Mukamal, Z. Gordon Jiang

Abstract #1734
Severe hepatic steatosis by controlled attenuation parameter predicts patient-reported outcomes independent of fibrosis
Hirsh Trivedi, Sebastian Niezen, Z. Gordon Jiang, Elliot B Tapper

Abstract #1754
Weight gain and nonalcoholic fatty liver disease and fibrosis detected by fibroscan in the United States
Karn Wijarnpreecha, Elizabeth Aby, Aijaz Ahmed, Donghee Kim

NAFLD and NASH: Experimental: Basic

AASLD Presidential Poster of Distinction
Abstract #1809
MTTP is associated with imaging measured nonalcoholic fatty liver disease in population based and biobank cohorts
Xiaomeng Du, Lc Stetson, Yanhua Chen, Annapurna Kuppa, Elizabeth K. Speliotes, GOLD Consortium

Abstract #1815
Perturbation of TM6SF2 alters hepatic lipid metabolism and lipid species composition
Asmita Pant, Yue Chen, Annapurna Kuppa, Xiaomeng Du, Brian D Halligan, Elizabeth K. Speliotes

Abstract #1834
The LMNA R644C variant is associated with hepatic steatosis in a large cohort and increases lipid accumulation in human hepatoma cells
Kapil Upadhyay, Xiaomeng Du, Yanhua Chen, Lc Stetson, M Bishr Omary, Elizabeth K. Speliotes, Graham Brady

Portal Hypertension and Other Complications of Cirrhosis: Ascites, Renal Dysfunction, and Hepatorenal Syndrome

Abstract #2006
Medication records, not diagnosis codes, are the optimal method to identify ascites using administrative data: A multicenter study
Jennifer Dziwis, Juan Gonzalez, Elliot B Tapper, Yuval Patel

Portal Hypertension and Other Complications of Cirrhosis: Encephalopathy, Infections, and Other Complications

Abstract #2039
Effect of fecal microbiota transplant on hepatic encephalopathy varies by donor and recipient factors
Patricia Bloom, John Donlan, Mariam Torres Soto, Michael Daidone, Elizabeth Hohmann, Raymond T Chung

Abstract #2066
Post-TIPS evolution of the echocardiographic markers of cirrhotic cardiomyopathy
John Laurenzano, Claire Harrington, Nikhilesh Mazumder, Jing Gao, Deepak Gupta, Anthony Borgmann, Lisa Van Wagner, Manhal Izzy, Justin Richard Boike

Vascular Liver Disease, Hemostasis and Thrombosis: Hemostasis and Thrombosis

Abstract #2150
Prophylactic use of blood products prior to paracentesis and thoracentesis among patients hospitalized with decompensated cirrhosis is related to provider specialty and not risk of bleeding or bleeding complications
Abhishek Shenoy, Elliot B Tapper, Anna S. Lok

Past AASLD Meetings

2020 AASLD - November 13–16

AASLD Foundation Awards

Clinical, Translational and Outcomes Research Award

Vincent Chen, MD
Project Title: Integrating genetic and environmental factors to predict risk of non-alcoholic fatty liver disease
Mentor: Elizabeth K. Speliotes, MD, PhD, MPH

Pilot Research Award

Jun Wu, PhD
Project Title: A novel cholinergic circuitry in hepatic regulation
Mentor: Liangyou Rui, PhD

Leadership Positions

Councilor and AASLD President in 2025

We congratulate Grace Su, MD, FAASLD on her election as Councilor for the term 2021 – 2026. She will become the AASLD President in 2025.

AASLD and SIG Committees, Journal Editorial Boards

Patricia P. Bloom, MD
Communications and Technology Committee
Trainee Member

Robert J. Fontana, MD, FAASLD
Nominating Committee
Member (Elected)
Hepatology Communications
Editorial Board
Hepatology Communications
Editorial Board

Anna S. Lok, MD, FAASLD
Hepatitis B SIG
Steering Committee
Hepatology
Editorial Board

Jessica L. Mellinger, MD, MSc
Alcohol-associated Liver Disease SIG
Steering Committee
Clinical Liver Disease
Editorial Board
Hepatology Communications
Editorial Board

Pratima Sharma, MD, MS
Acute on Chronic Liver Failure SIG
Steering Committee
Liver Transplantation and Surgery SIG
Steering Committee
Public Policy Committee
Member
Liver Transplantation
Associate Editor

Elizabeth K. Speliotes, MD, PHD, MPH
Research Awards Committee
Member

Grace L. Su, MD, FAASLD
Annual Meeting Education Committee
Chair
Maintenance of Certification (MOC) Committee
Member
Scientific Program Committee
Member

Elliot B. Tapper, MD
Cirrhosis Quality Collaborative (CQC)
Steering Committee
Practice Metrics Committee
Chair-Elect
Public Health / Health Care Delivery SIG
Steering Committee
Hepatology
Editorial Board
Hepatology Communications
Editorial Board

Monica A. Tincopa, MD, MSc
Clinical Research Committee
Member

The Liver Meeting Program - Chairs, Moderators

Saturday, November 14, 2020

Emerging Trends Symposium
Artificial Intelligence (AI) in Hepatology
9:00 – 10:30 am
Co-chair: Grace L. Su

Parallel Session 2: Liver Transplantation: Immunosuppression/Outcomes/Complication
2:00 – 3:30 pm
Moderator: Pratima Sharma

Sunday, November 15, 2020

COVID-19 and the Liver Symposium
2:00 – 3:30 pm
Moderator: Robert J. Fontana 

Parallel Session 16: Hepatobiliary Neoplasia: Experimental and Novel Diagnostic/Imaging
5:30 – 7:00 pm
Moderator: Grace L. Su

Parallel Session 17: Hepatotoxicity
5:30 – 7:00 pm
Moderator: Robert J. Fontana

Monday, November 16, 2020

Parallel Session 20: Hepatobiliary Neoplasia: Clinical
9:00 – 10:30 am
Moderator: Neehar Parikh

Special Session

Conversation with our Nobel Laureates (2020 Nobel Laureates in Physiology and Medicine, Harvey Alter, MD, Michael Houghton, PhD, Charles Rice, PhD)
12:00-1:00 pm
Moderators: Jorge Bezerra, Raymond Chung, Anna Lok

Postgraduate Course

Saturday, November 14, 2020

Part 1. Paradigm Shifts in Hepatology: Rethinking Conventional Wisdom
8:00 am – 12:00 pm

In Session I Toward a biopsy-free world
Elliot B. Tapper

In Session V HBV and HDV: Can we now talk about cure?
Anna S. Lok

Oral Abstract Presentations

Saturday, November 14, 2020

Parallel Session: Hepatitis B: Therapeutics (Established)
9:00 – 10:30 am

9:00 am
Abstract #19
Randomized trial of 192 weeks of tenofovir with or without peginterferon alfa for the first 24 weeks followed by protocolized withdrawal in adults with chronic hepatitis B
Norah Terrault, Anna S Lok, Abdus Wahed, David KH Wong, Mandana Khalili, Michael W Fried, Daryl Lau, Marc G Ghany, Richard K Sterling, Adrian M Di Bisceglie, Robert P Perrillo, Mauricio Lisker-Melman, Stewart Cooper, Raymond T Chung, Keyur Patel, Lewis R Roberts, Charles Landis, Mohamed A Hassan, Christopher A Aoki, Steve Belle, Harry LA Janssen

Sunday, November 15, 2020

Presidential Plenary – Clinical and Outcomes Discoveries
9:00 – 10:30 am

AASLD Foundation Abstract Award
Abstract #9
Predictors of outcomes of COVID-19 in patients with chronic liver disease: US multi-center study
Nia Adeniji, Donghee Kim, Nyan L Latt, Sonal Kumar, Patricia P Bloom, Elizabeth S Aby, Ponni V. Perumalswami, Marina Roytman, Michael Li, Alexander S Vogel, Andreea M Catana, Kara Wegermann, Rotonya M Carr, Costica Aloman, Vincent Chen, Akshata Moghe, Veronica Nguyen, Brett Sadowski, Atoosa Rabiee, Winston Dunn, Kenneth D. Chavin, Kali Zhou, Blanca Lizaola-Mayo, Jose D Debes, Tzu-Hao Lee, Andrea D Branch, Kathleen Viveiros, Walter W Chan, David M Chascsa, Paul Y Kwo, Renumathy Dhanasekaran

Parallel Session 17: Hepatotoxicity
5:30 – 7:00 pm

Abstract #117
HLA risk alleles associated with drug induced liver injury due to antiepileptic drugs
Paola Nicoletti, Yi-Ju Li, Elizabeth J Phillips, Andrew Dellinger, Huiman Barnhart, Robert J Fontana, Herbert L Bonkovsky, Naga P Chalasani, and for the Drug Induced Liver Injury Network (DILIN)

Monday, November 16, 2020

Parallel Session 19: Acute/Acute on Chronic Liver Failure
9:00 am

Abstract #127
Prediction of survival in adults with ALF and non-acetaminophen ALI using the 13C methacetin breath test: Results of a prospective, multicenter trial
Robert J Fontana, R Todd Stravitz, Valerie L Durkalski-Mauldin, James Hanje, Bilal Hameed, David G Koch, Daniel R Ganger, Jody C Olson, Iris W Liou, Brendan M McGuire, Kristen Clasen, William M Lee

Parallel Session: Hepatitis B: Non-Therapy
10:30 am – 12:00 pm

Abstract #157
Do novel assays improve phenotypic characterization of adults with chronic hepatitis B?
Marc G Ghany, Wendy King, Mauricio Lisker-Melman, Gavin Cloherty, Mandana Khalili, Raymond T Chung, Norah Terrault, William M Lee, Daryl Lau, Harry LA Janssen, Anna S Lok, Richard K Sterling, and on behalf of the HBRN

Oral Session
Abstract #62
Association of serum biomarkers with liver stiffness assessed by transient elastography in 330 children with cholestatic liver disease
Daniel H Leung, Sridevi Devaraj, Nathan P Goodrich, Xinpu Chen, Deepthi B Rajapakshe, Wen Ye, Victor Andreev, Charles Minard, Danielle Guffey, Jean Pappas Molleston, Lee M Bass, Saul J Karpen, Binita M Kamath, Kasper S Wang, Shikha S Sundaram, Philip Rosenthal, Patrick James McKiernan, Kathleen M Loomes, M Kyle Jensen, Simon P Horslen, Jorge A Bezerra, John C Magee, Robert Merion, Ronald J Sokol, Benjamin L Shneider

Oral Session
Abstract #73
The relationship between physical frailty and impaired cognition in patients with cirrhosis
Kacey Berry, Andres Duarte-Rojo, Joshua D Grab, Michael A Dunn, Brian J Boyarsky, Betsy C Verna, Matthew R Kappus, Michael Volk, Mara McAdams-DeMarco, Dorry L Segev, Daniel R Ganger, Daniela P Ladner, Monica A Tincopa, Robert S Rahimi, Jennifer Cindy Lai

Oral Session
Abstract #339
Prognostic value of serum bile acids after achieving bile flow with the Kasai portoenterostomy in biliary atresia (formerly a poster abstract) okay to delete?
Sanjiv Harpavat, Kieran Hawthorne, Benjamin L Shneider, Lisa Henn, Charlotte Beil, Saul J Karpen, Vicky Lee Ng, Kenneth DR Setchell, Estella M Alonso, Jorge A Bezerra, Stephen L Guthery, Simon P Horslen, Binita M Kamath, Kathleen M. Loomes, Patrick James McKiernan, John C Magee, Robert M Merion, Jean Pappas Molleston, Philip Rosenthal, Richard J Thompson, Kasper S Wang, Ronald J Sokol, James E Heubi

Oral Session
Abstract #374
Multiomic integrated molecular landscape of hyperammonemia show a time-dependent change in chromatin accessibility and the translatome of sarcopenia of cirrhosis
Nicole M Welch, Avinash Kumar, Shashi S Singh, Saurabh Mishra, Jinendiran Sekar, Annette Bellar, Lin Ling, Dongmei Zhnag, Belinda Willard, Michelle Longworth, Yatrik Shah, Srinivasan Dasarathy

Posters

>>Acute/Acute on Chronic Liver Failure

Abstract #184
Bleeding, thrombosis, and outcome according to rotational thromboelastometry (ROTEM) parameters in patients with acute liver injury/failure
R Todd Stravitz, Robert J Fontana, Caitlyn Meinzer, Valerie L Durkalski-Mauldin, Adam James Hanje, Jody C Olson, David G Koch, Bilal Hameed, Michael L Schilsky, Brendan M McGuire, Daniel R Ganger, Iris W Liou, Constantine J Karvellas, Ton Lisman, Kristen Clasen, William M Lee, ALF Study Group

Abstract #186
CPS1 is a prognostic biomarker in patients with acute liver failure
Raymond Kwan, Min-Jung Park, Sujith VW Weerasinghe, Zemin Su, William M Lee, Valerie L Durkalski-Mauldin, Robert J Fontana, M Bishr Omary

AASLD Presidential Poster of Distinction
Abstract #203
Trends in severe acute idiosyncratic drug induced liver injury: An update from the ALFSG Registry
Ashwin Rao, Jody A Rule, Bilal Hameed, Daniel R Ganger, Robert J Fontana, William M Lee

>>Alcohol Associated Liver Disease: Clinical and Experimental

Abstract #276
Provider attitudes and practices for alcohol screening, treatment and education in patients with liver disease
Jessica L Mellinger, Gene Y Im, Adam Winters, Elizabeth S Aby, Zurabi Lominadze, Michael R Lucey, John P Rice, Loretta Jophlin, Juan Pablo Arab, Aparna Goel, Courtney Sherman, Deepika Devuni, Richard Parker, Po-Hung Chen, Sandeep Sidhu, Winston Dunn, Gyongyi Szabo, Ashwani K Singal, Vijay Shah

>>COVID-19 and the Liver

Abstract #430
COVID-19 outcomes among solid organ transplant recipients: a matched case-control study
Pratima Sharma, Vincent Chen, Christopher M Fung, Jonathan P Troost, Vaiibhav N Patel, Michael Combs, Silas P Norman, Puneet Garg, Monica Colvin, Keith Aaronson, Christopher J Sonnenday, Jonathan Golob, Emily C Somers, Mona M Doshi

Abstract #438
Hepatic steatosis is associated with elevated alanine aminotransferase (ALT) but not elevated bilirubin or hepatic decompensation in patients with novel coronavirus disease 2019 (COVID-19)
Ihab A Kassab, Fadi Hawa, Jeffrey A Berinstein, Calen A Steiner, Kevin D Platt, Jeremy Louissaint, Chia-Yang Hsu, Chanakyaram A Reddy, Naresh T Gunaratnam, Vincent Chen, Pratima Sharma

Abstract #439
Hepatic steatosis is associated with increased disease severity in patients with novel coronavirus 2019 (COVID-19)
Fadi Hawa, Ihab A Kassab, Jeffrey A Berinstein, Calen A Steiner, Kevin D Platt, Jeremy Louissaint, Chia-Yang Hsu, Chanakyaram A Reddy, Naresh T. Gunaratnam, Vincent Chen, Pratima Sharma

Abstract #471
Patterns and predictors of liver injury in liver transplant recipients with coronavirus disease 2019 (COVID-19)
Atoosa Rabiee, Brett Sadowski, Nia Adeniji, Veronica Nguyen, Akshata Moghe, Ponni V Perumalswami, Nyan L Latt, Sonal Kumar, Costica Aloman, Maria-Andreea Catana, Patricia P Bloom, Kenneth D Chavin, Rotonya M Carr, Winston Dunn, Vincent Chen, Elizabeth S Aby, Jose D Debes, Renumathy Dhanasekaran, COLD Consortium

>>Genomics and Precision Medicine

Abstract #606
Polygenic risk scores for transaminases are associated with hepatic steatosis and cirrhosis
Vincent Chen, Xiaomeng Du, Yanhua Chen, LC Stetson, Elizabeth K Speliotes

>>Cirrhosis

Abstract #627
A telemonitoring system is feasible for outpatient cirrhotic ascites management
Patricia P Bloom, Zoe Reinus, Jessica Shay, Jasmine Ha, James M Richter

>>Health Services Research: Patient Centered Outcomes Research

Abstract #703
Cost-effectiveness of alcohol cessation interventions among patients with alcohol-related cirrhosis
Anton Avencena, Nicholas Miller, Sarah Uttal, David Hutton, Jessica L Mellinger

>>Hepatitis B: Epidemiology, Prevention, Natural History

Abstract #773
Symptoms of chronic liver disease are associated with higher risk of adverse clinical outcomes: A longitudinal study in a large cohort of North American adults with chronic hepatitis B
Donna M Evon, Hsing-Hua Lin, Robert J Fontana, Mandana Khalili, Colina K Yim, Abdus Wahed, Jay H Hoofnagle, Hepatitis B Research Network (HBRN) 

>>Hepatobiliary Neoplasia: Clinical

AASLD Presidential Poster of Distinction
Abstract #1057
Incidence and predictive factors of hepatocellular carcinoma (HCC) in a prospectively followed US cohort of patients at risk: Hepatocellular carcinoma early detection strategy (HEDS) study
K Rajender Reddy, Neehar D Parikh, Lewis R Roberts, Myron E Schwartz, Mindie H Nguyen, Alex Befeler, Stephanie Page-Lester, Dale McLerran, Sudhir Srivastava, Jo Ann Rinaudo, Ziding Feng, Jorge A Marrero 

>>Hepatotoxicity: Pathogenesis and Mechanisms; Drug Metabolism, Toxicity, and Therapeutics; Predictors of Drug Toxicity

Abstract #1181
A revised electronic version of RUCAM for the diagnosis of drug induced liver injury
Paul H Hayashi, M Isabel Lucena, Robert J Fontana, Einar Bjornsson, Guruprasad P Aithal, Huiman Barnhart, A Gonzalez-Jimenez, Qinghong Yang, Jiezhun Gu, Raul J Andrade, Jay H Hoofnagle, DILIN Investigators

Abstract #1185
Checkpoint inhibitor hepatotoxicity is characterized by peripheral eosinophilia and hepatocellular or mixed injury at onset but a low risk of liver failure during follow-up
Robert J Fontana

Abstract #1194
Identifying cases of idiosyncratic drug-induced liver injury using ICD-10 codes for drug toxicity/poisoning and liver failure
Jeremy Louissaint, Ihab A Kassab, Amoah Yeboah-Korang, Robert J Fontana

>>Liver Transplantation

Abstract #1317
Automated measurements of body composition in abdominal CT scans using deep learning can predict survival in patients with cirrhosis
Winnie Zou, Binu Enchakalody, Nidhi Shah, Peng Zhang, Grace L Su

Abstract #1342
Factors associated with cardiovascular events after simultaneous liver kidney transplant (SLKT): Results from the U.S. multicenter SLKT Consortium
Jennifer Jo, Dyanna Gregory, Jasmine Sinha, Jiaheng Xie, Min ZhangJohn C Magee, Pranab M. Barman, Yuval Patel, Aaron Schluger, Kara Walter, Scott W Biggins, Giuseppe Cullaro, Randi Wong, Jennifer Cindy Lai, Elizabeth C Verna, Pratima Sharma, Lisa B VanWagner

Abstract #1389
Predictors of length of stay and death for simultaneous liver–kidney transplant (SLKT) index admission: Results from the US multicenter SLKT Consortium
Pranab M Barman, Jiaheng Xie, Min Zhang, Jennifer Jo, Jasmine Sinha, Aaron Schluger, Kara Walter, Scott W Biggins, Giuseppe Cullaro, Randi Wong, Jennifer Cindy Lai, Lisa B. VanWagner, John C Magee, Betsy C Verna, Yuval Patel, Pratima Sharma

Abstract #1402
Risks of early hospitalization after simultaneous liver and kidney transplant (SLKT): Analysis from the United States (US) multicenter SLKT Consortium
Pratima SharmaJiaheng Xie, Min Zhang, Pranab M Barman, John C Magee, Jennifer Jo, Jasmine Sinha, Aaron Schluger, Kara Walter, Giuseppe Cullaro, Randi Wong, Scott W Biggins, Jennifer Cindy Lai, Lisa B VanWagner, Betsy C Verna, Yuval Patel

Abstract #1419
The relationship between frailty and etiology of cirrhosis: from the multi-center functional assessment in liver transplantation (FRAILT) study
Chelsea Xu, Yara Mohamad, Matthew R Kappus, Brian J Boyarsky, Daniel R Ganger, Michael Volk, Robert S Rahimi, Andres Duarte-Rojo, Mara McAdams-DeMarco, Dorry L Segev, Daniela P Ladner, Betsy C Verna, Monica A Tincopa, Michael A Dunn, Jennifer Cindy Lai

>>Liver Disease and Cystic Fibrosis

Abstract #1457
Characteristics and clinical liver disease in children with sonographic nodular liver (sonic) in cystic fibrosis
Jean Pappas Molleston, Wen Ye, Sarah Jane Schwarzenberg, Alvin J Freeman, Joseph Palermo, Alexander Weymann, Estella M Alonso, Wikrom Karnsakul, Karen F Murray, John C Magee, Daniel H Leung, Michael R Narkewicz,

>>Nonalcoholic Fatty Liver Disease

Abstract #1565
A pragmatic clinical prognostic classification suitable for universal application stratifies patients with NAFLD by risk of mortality and both hepatic and extrahepatic outcomes
Arun J Sanyal, Meng Wang, Kenneth Cusi, Alfred Sidney Barritt IV, Mark Dhinesh Muthiah, Stephanie Watkins, K Rajender Reddy, Roberto J Firpi, Paul J. Thuluvath, Kalyan Ram Bhamidimarri, Anna S Lok, Michael W Fried 

Abstract #1569
Association of nonalcoholic fatty liver disease with cognition and brain volumes in the ACCORD randomized clinical trial
Neal Parikh
, Cenai Zhang, Russell Rosenblatt, Sonal Kumar, Elliot B Tapper, Hooman Kamel, Costantino Iadecola

>>Nonalcoholic Steatohepatitis

Abstract #1574
Burden of stage 2/3 fibrosis associated with nonalcoholic steatohepatitis: A cost of illness analysis
Darshini Shah, Elliot B Tapper, Kate Burslem, Steve Marcus, Jalpa A Doshi 

Abstract #1595
Heterogeneous documentation and poor concordance of NASH pathology may limit its clinical utility in real-world practice
Hannah Kim, Michael O Idowu, Richard C. Zink, Andrea Mospan, Michael Roden, Philip N Newsome, Anna S Lok, Paul J Thuluvath, Jawahar L Taunk, Michael W Fried, Arun J Sanyal, Alfred Sidney Barritt IV

>>Other Portal Hypertension Complications

Abstract #1743
Comparison of seven noninvasive models for predicting decompensation and hospitalization in patients with cirrhosis
Chia-Yang Hsu, Teh-Ia Huo, Neehar D. Parikh, Elliot B Tapper

AASLD Presidential Poster of Distinction
Abstract #1758
Hepatic encephalopathy is associated with a distinct speech pattern
Patricia P Bloom, Ashwini Arvind, Michael Daidone, Jessica Robin, Mengdan Xu, Anoopum S Gupta, Raymond T Chung

Abstract #1769
Noninvasive liver indices predict early decompensation in patients with newly diagnosed cirrhosis
Chia-Yang Hsu, Neehar D Parikh, Elliot B Tapper, Teh-Ia Huo

Abstract #1771
Nonselective beta-blocker use as an independent predictor of total number of hepatic encephalopathy-related admissions in patients with cirrhosis
Mohammad Amin Fallahzadeh, Sumeet K Asrani, Elliot B Tapper, Giovanna Saracino, Daniel Bizzarri, Robert S Rahimi

Abstract #1776
Prophylaxis and treatment of hepatic encephalopathy improves health-related quality of life, sleep, and social functioning
Andrew Moon, Hannah Kim, Jennifer S Walker, Charles Poole, Alfred Sidney Barritt IV, Elliot B Tapper

Abstract #1826
Morbidity and mortality following emergent or non-emergent umbilical hernia surgery in a national sample of US veterans with or without cirrhosis
Kay Johnson, Kira Newman, Kristin Berry, Pamela Green, Peter C Wu, Paul B Cornia, Lauren A. Beste, Kamal Itani, Alex HS Harris, Patrick S Kamath, George Ioannou

2019 AASLD - November 8–12

Awards

Vincent Chen, MD, MS
Clinical Lecturer
Early Career Investigator Award in Clinical/Translational Science

Mary Thomson, MD
Advanced Transplant Hepatology Fellow
Advanced/Transplant Hepatology Award

Leadership Positions

Hari Conjeevaram, MD, MS – Professor
Training and Workforce Committee

Robert Fontana, MD – Professor
Clinical Research Committee
AASLD Nominating Committee
Hepatology, Editorial Board
Hepatology Communications, Editorial Board

Anna Lok, MD – Professor
Global Outreach and Engagement Committee, Global Advisory Council Chair
Hepatology, Editorial Board

John C. Magee, MD – Professor
Scientific Program Committee
Surgery and Liver Transplantation Committee, Chair

Jessica Mellinger, MD, MS – Assistant Professor
Hepatology Communications, Editorial Board
Clinical Liver Diseases, Editorial Board

Neehar Parikh, MD, MS – Assistant Professor
Practice Metrics Committee

Pratima Sharma, MD, MS – Associate Professor
Publications Committee
Public Policy Committee
Liver Transplantation, Associate Editor

Grace Su, MD – Professor
Annual Meeting Education Committee, Chair
Scientific Program Committee
Maintenance of Certification (MOC) Committee

Andrew Tai, MD, PhD – Associate Professor
Research Awards Committee

Elliot Tapper, MD – Assistant Professor
Practice Metrics Committee, Vice Chair
Hepatology Communications, Editorial Board
Hepatology, Editorial Board

The Liver Meeting Program - Moderators, Chairs

Sunday, November 10, 2019

Parallel 2: Hepatitis C: Long-Term Outcomes and Unique Populations
CC, Room 304/306
8:30-10:00 am
Moderators: Grace L. Su, Raymond Chung

Parallel 11: Liver Transplant: Renal and Metabolic Issues
CC, Room 304/306
2:00-3:30 pm
Moderators: Pratima Sharma, Glen Lutchman

Parallel 14: HCC Translational and Biomarkers
CC, Ballroom BC
4:30-6:00 pm
Moderators: Denise Harnois, Neehar D. Parikh

#LiverTwitter: An Emerging Tool for Liver Education and Research
CC, Room 312
2:00-3:30 pm
Chairs: Elliot B. Tapper, Rohit S. Satoskar

Postgraduate Course

Saturday, November 9, 2019

Session I – Precision Medicine in 2019
CC Auditorium
8:45–9:05 am
Precision medicine and patients at risk for drug-induced liver injury
Robert Fontana

Workshops, Courses, President's Choice Lecture, Global Forum

Friday, November 8, 2019

Career Development Workshop
CC, Room 311
2:20 pm
How to be a good mentee and identify mentors/sponsors to launch your career
Elliot B. Tapper

2:50 pm
How I make time for myself and my work
Monica Tincopa

Saturday, Nov 9, 2019

Meet-the-Professor Luncheon (MTP) 1
12:00 pm
Ask the expert on cirrhosis: What are the best strategies to avoid readmissions?
Elliot B. Tapper, Fasiha Kanwal

Transplant Surgery Workshop
CC, Room 304/306
2:50 pm
Case Presentation Stimulated Panel Discussion/Q&A
Monica Tincopa

Sunday, Nov 10, 2019

Diversity Workshop
CC, Room 311
10:35 am
Creating solutions for racial and ethnic disparities in health
John Carethers

Hepatology Associates Course
Sheraton, Constitution Ballroom
11:25 am
Hepatitis B update
Anna S. Lok

#LiverTwitter: An Emerging Tool for Liver Education and Research
CC, Room 312
2:05 pm
Setting up your Twitter, sending your first Tweet
Elliot B. Tapper

2:25 pm
Running a divisional Twitter account
Neehar Parikh

Value-Based Medicine in Hepatology
Sheraton, Republic Ballroom
3:25 pm
Telehealth for high-value liver care
Grace L. Su

President's Choice Lecture
CC, Auditorium
4:00 pm
Global Health
Tadataka Yamada

Monday, November 11, 2019

Early Morning Workshop - EMW–43
6:45 – 7:45 am
Quality and safety for hospitalized patients with cirrhosis
Elliot B. Tapper

Global Forum – Alcohol-Related Liver Disease (ALD)
CC, Room 312
3:20 PM
AASLD/U.S. Perspective
Jessica Mellinger

Abstracts – Oral Presentations

Sunday, November 10, 2019

Parallel 5: Health Service Research: Patient Centered Outcomes
CC, Room 312
10:30 am
0055
Patients with decompensated cirrhosis are not receiving the medications they need while receiving medications they do not need
Mary Thomson, Anna S. Lok, Elliot B. Tapper

11:45 am
0060
A prospective study to define the contemporary health state utilities for persons with cirrhosis
Chelsey Foster, Samantha Nikirk, Jad Baki, Neehar D. Parikh, Elliot B. Tapper        

Parallel 11: Liver Transplant: Renal and Metabolic Issues
CC, Room 304/306
3:15 pm
0096
Muscle mass measurements can be automated using deep learning
Nicholas Wang, Stewart Wang, Grace L. Su

Parallel 16: Health Services Research: Healthcare Delivery and Access
Sheraton, Republic Ballroom
4:30 pm
0121
Gastroenterology consultation improves mortality and healthcare utilization after hepatic encephalopathy: The first population-based outcomes study of Americans with cirrhosis
Elliot B. Tapper, Devin Aberasturi

5:00 pm
0123
Inpatient access to specialty care for cirrhosis-related admissions and its impact on length of stay, mortality, and 30-day readmissions in two large national cohorts
Marina Serper, David E. Kaplan, Tamar H Taddei, Elliot B. Tapper

Monday, November 11, 2019

Parallel 22: HBV Epidemiology Prevention
CC, Ballroom A
9:45 am
0162
Hepatic fat and steatohepatitis in a large multiethnic North American cohort of adults and children with chronic hepatitis B
Mandana Khalili, David Kleiner, Wendy King, Richard K. Sterling, Marc G. Ghany, Raymond T. Chung, Philip Rosenthal, Lisker-Melman, Rageshree Ramachandran, Ahul Bhan, Anna S. Lok

Parallel 29: HCC Treatment: Medical Approaches
CC, Ballroom BC
10:30
0199
Direct-acting antiviral therapy is associated with improved survival in patients with a history of hepatocellular carcinoma: A multicenter North American cohort study
Amit G. Singal, Nicole E. Rich, Neil Mehta, Andrea D. Branch, Anjana A. Pillai, Maarouf A. Hoteit, Michael Volk, Mobolaji Odewole, Steven J. Scaglione, Jennifer E. Guy, Adnan Said, Jordan J. Feld, Binu John, Catherine T. Frenette, Parvez S. Mantry, Amol S. Rangnekar, Omobonike Oloruntoba, Michael D Leise, Janice Jou, Kalyan Ram Bhamidimarri, Laura M. Kulik, George Ioannou, Annsa Huang, Tram T. Tran, Hrishikesh V. Samant, Renumathy Dhanasekaran, Andres Duarte-Rojo, Reena J. Salgia, Sheila L. Eswaran, Prasun K. Jalal, Avegail Flores, Sanjaya Kumar Satapathy, Neehar D. Parikh, Caitlin Murphy

11:00 am
0201
Financial burden is common in U.S. patients with cirrhosis and associated with lower HCC surveillance receipt
Amit G. Singal, Katharine McCallister, Cynthia Ortiz, Jennifer Kramer, Song Zhang, Aisha Khan, Yan Liu, Nicole E. Rich, Neehar D. Parikh, Jasmin Tiro, Purva Gopal, Simon Lee, Caitlin Murphy, Ruben Hernaez

Parallel 31: Hepatotoxicity
CC, Room 302
10:30 am
0211
Discovery of ERAP2 gene expression as a risk factor for drug-induced liver injury due to amoxicillin–clavulanic acid
Paola Nicoletti, Federico Innocenti, Amy Etheridge, Naga P. Chalasani, Robert J. Fontana, Yi-Ju Li, Joseph Odin, Jose Serrano, Andrew Stolz, Guruprasad Aithal, Ann K. Daly, Paul B. Watkins, DILIN Investigators

10:45 am
0212
Increasing episodes of hepatotoxicity in the Drug-Induced Liver Injury Network associated with kratom, a botanical product with opioid-like activity
Victor J. Navarro, Joseph Odin, Jawad Ahmad, Paul H. Hayashi, Robert J. Fontana, Hari S. Conjeevaram, Bharathi Avula, Ikhlas Khan, Huiman Barnhart

Parallel 35: NAFLD and NASH: Epidemiology and Outcomes
Sheraton, Constitution Ballroom
3:15 pm
0240
Incidence of achieving weight loss goals in usual clinical practice: results for the TARGET-NASH observational cohort
Miguel H. Malespin, Alfred Sidney Barritt IV, Stephanie Watkins, Cheryl Schoen, Monica A. Konerman, Karen Corbin, Huy N. Trinh, L Michael Weiss, K Rajender Reddy, Rohit Loomba, Nyingi Kemmer, Anna S. Lok

Parallel Session: Late-Breaking Abstracts Oral Session I
CC, Auditorium
3.30 PM
LO5
The CONFIRM Study: A North American randomized controlled trial (RCT) of terlipressin plus albumin for the treatment of hepatorenal syndrome type 1 (HRS-1)
Florence Wong, Michael P Curry, K. Rajender Reddy, Raymond A Rubin, Michael K Porayko, Stevan Gonzales, Khalid Mumtaz, Nicholas Lim, Douglas Simonetto, Pratima Sharma, Arun Sanyal, Marlyn Mayo, Todd Frederick, S. Chris Pappas, Khurram Jamil on behalf of the CONFIRM Study Investigators

Abstracts – Poster Presentations

Friday, November 8, 2019

0318
Prognostic nutritional index is associated with improved survival in patients with hepatocellular carcinoma

Nicole E. Rich, Aarthi Parvathaneni, Adam C Yopp, Ahana Sen, Mobolaji Odewole, Ju Dong Yang, Yujin Hoshida, Neehar D. Parikh, Jorge A. Marrero, Amit G. Singal

0320
Prospective evaluation of benefits and harms of HCC surveillance in a cirrhosis patient population

Sruthi Patibandla, Joseph Obi Jr., Hannah Fullington, Katharine McCallister, Nicole E. Rich, Neehar D. Parikh, Purva Gopal, Jorge A. Marrero, Amit G. Singal

0322
Comparison of characteristics and prognosis of U.S. – Japan hepatocellular carcinoma patients detected under surveillance
Hidenori Toyoda, Satoshi Yasuda, Takashi Kumada, Atsushi Hiraoka, Neehar D. Parikh, Amit G. Singal

0335
Multicenter cohort study of thermal ablation versus stereotactic body radiation therapy for hepatocellular carcinoma
Andrew Moon, Dawn Owen, Hannah Kim, Emily Sanders, Christian Beyer, Katrina A McGinty, Lauren M Burke, Paul H. Hayashi, Joel E Tepper, Paula D Strassle, Theodore S Lawrence, Charles S Mayo, Mishal Mendiratta-Lala, Neehar D. Parikh, Amit G. Singal, Karyn A Goodman, Marina Moskalenko, Daniel R Simpson, John Do, Yuko Kono, Steven C Rose, Jona A Hattangadi-Gluth, David A. Gerber, Kyle Wang

0369
Transarterial chemoembolization versus transarterial radioembolization for patients with hepatocellular carcinoma: a meta-analysis
Andrew Brown, Ihab A Kassab, Vincent L Chen, Whitney A Townsend, Amit G. Singal, Neehar D. Parikh

0390
Cost effectiveness of hepatocellular carcinoma surveillance: An assessment of benefits and harms
Neehar D. Parikh, Amit G. Singal, David Hutton, Elliot B. Tapper

0407
Opioid prescriptions are associated with hepatic encephalopathy in a national cohort of privately-insured patients with compensated cirrhosis
Andrew Moon, Yue Jiang, Shari S Rogal, Elliot B. Tapper, Sarah Rosanna Lieber, Alfred Sidney Barritt IV

0491
Effectiveness of tenofovir alafenamide in patients with chronic hepatitis B treated in usual clinical practice: Results from the TARGET-HBV observational cohort study
David Eric Bernstein, Huy N. Trinh, Eugene R. Schiff, Coleman I Smith, Richard Zink, Anna S. Lok

0615
Diagnostic and treatment delays are common in patients with hepatocellular carcinoma

Ashwin Rao, Amit G. Singal, Neehar D. Parikh, Nicole E. Rich

0618
The impact of socioeconomic status on cirrhosis and hepatocellular carcinoma in the United States
Roselyn Nsenga, Sophia Tzavaras, Daniel Waldo, Amit G. Singal, Elliot B. Tapper, Neehar D. Parikh

0724
Patient knowledge deficits are associated with lower HCC surveillance receipt
Amit G. Singal, Katharine McCallister, Cynthia Ortiz, Jennifer Kramer, Song Zhang, Yan Liu, Aisha Khan, Nicole E. Rich, Jasmin Tiro, Neehar D. Parikh, Simon Lee, Caitlin Murphy, Ruben Hernaez

0727
Significant depression and anxiety are common in U.S. patients with cirrhosis
Amit G. Singal, Nicole E. Rich, Katharine McCallister, Cynthia Ortiz, Aisha Khan, Jennifer Kramer, Song Zhang, Elliot B. Tapper, Neehar D. Parikh, Jasmin Tiro, Simon Lee, Caitlin Murphy, Ruben Hernaez

0737
Patient-reported outcomes associated with chronic hepatitis B viral (HBV) infection in a large North American cohort: A cross-sectional analysis
Donna M. Evon, Hsing-Hua Lin, Mandana Khalili, Robert J. Fontana, Colina K. Yim, Abdus Wahed, Michael W Fried, Jay H. Hoofnagle, Hepatitis B Research Network (HBRN)

Saturday, November 9, 2019

0828
A prospective study of hepatitis E virus infection in North American patients with severe acute liver injury

Robert J. Fontana, Ronald E Engle, Michelle Gottfried, Hanje James, Bilal Hameed, Valerie L Durkalski-Mauldin, William M Lee, Patrizia Farci

0833
Does acute hepatitis C virus (HCV) infection ever lead to acute liver failure?
Jody A. Rule, Giuliana Cerro, R. Todd Stravitz, Brendan Martin McGuire, Robert J. Fontana, Dr. Jorge L. Rakela, William M Lee

0842
Growth rates of untreated hepatocellular carcinoma in patients with cirrhosis: A multicenter cohort study

Nicole E. Rich, Binu John, Neehar D. Parikh, Ian Rowe, Neil Mehta, Gaurav Khatri, Smitha Thomas, Munazza Anis, Mishal Mendiratta-Lala, Christopher Hernandez, Mobolaji Odewole, Latha T. Sundaram, Venkata R Konjeti, Shishir Shetty, Tahir Shah, Hao Zhu, Adam C Yopp, Yujin Hoshida, Jorge A. Marrero, Amit G. Singal

0881
No association between hepatocellular carcinoma surveillance and survival among patients with cirrhosis in the Optum database
Vincent L Chen, Elliot B. Tapper, Amit G. Singal, Neehar D. Parikh

0948
Low incidence of clinical outcomes in patients with chronic HBV infection in the era of nucleos(t)ide analogue (NA) therapy: Report from the Hepatitis B Research Network (HBRN) Adult Cohort Study
Anna S. Lok, Harry L. A. Janssen, Christina Lalama, Michael W Fried, Steve Belle, Robert P Perrillo, Dr. Marc G. Ghany, Mandana Khalili, Hepatitis B Research Network (HBRN)

0959
Incidence of HBsAg loss and HBeAg seroreversion among adults and children with HBeAg-negative chronic hepatitis B: Prospective analysis of a multi-ethnic North American cohort
Norah Terrault, Junyao Wang, Marc G. Ghany, Jordan J. Feld, Mandana Khalili, Philip Rosenthal, Robert J. Fontana, Mauricio Lisker-Melman, Richard K. Sterling, Raymond T. Chung, Harry L. A. Janssen

1131
The proportion of marijuana users among adult liver transplant candidates is increasing over time
Alisa Likhitsup, Gerald Winder, Ammar Hassan, Naba Saeed, Christopher J. Sonnenday, Robert J. Fontana

Sunday, November 10, 2019

1372
Bariatric surgery is associated with increased risk of alcohol-related cirrhosis and alcohol misuse
Jessica L. Mellinger, Kerby Shedden, Gerald Winder, Anne Fernandez, Brian Lee, Jennifer Waljee, Robert J. Fontana, Michael Volk, Frederic C Blow, Anna S. Lok

1738
Routinely available noninvasive tests perform well in identifying patients with advanced fibrosis due to NASH: Data from the TARGET-NASH observational cohort
Alfred Sidney Barritt IV, Anna S. Lok, K Rajender Reddy, L Michael Weiss, Roberto J. Firpi, Paul J. Thuluvath, Huy N. Trinh, Stephen Djedjos, Richard Haubrich, Andrew Billin, Bruce Koch II, Richard Zink, Arun J Sanyal, Kenneth Cusi, Brent A Neuschwander-Tetri

Monday, November 11, 2019

1855
Dependence of extrahepatic cholangiocyte proliferation on WNT signaling in in vivo murine and in vitro organoid co-culture models
Junya Shiota, Nureen Hanisah Mohamad Zaki, Linda Samuelson, Nataliya Razumilava

1892
Genome-wide association study of alanine transaminase and aspartate transaminase identifies diverse disease pathologies and effects on metabolic traits
Vincent L Chen, Xiaomeng Du, Yanhua Chen, Samuel Handelman, Elizabeth K. Speliotes

1905
Genetic variants that associate with liver cirrhosis have pleiotropic effects on human traits
Vincent L Chen, Yanhua Chen, Xiaomeng Du, Samuel Handelman, Elizabeth K. Speliotes

1906
Genome-wide association study for serum alkaline phosphatase identifies novel associations that affect liver and metabolic disease
Vincent L Chen, Xiaomeng Du, Yanhua Chen, Samuel Handelman, Elizabeth K. Speliotes

1910
GWAS of alcohol consumption in the UK biobank identifies variants that associate with metabolic and tissue-specific alcohol disease
Daniel Seung Kim, Xiaomeng Du, Yanhua Chen, Yatong K Li, Samuel Handelman, Jessica L. Mellinger, Elizabeth K. Speliotes

1911
Genetic variation in genes in the FXR/RXR pathways underlies effects on serum lipids and NAFLD
Samuel Handelman, Xiaomeng Du, Yanhua Chen, Elizabeth K. Speliotes

2036
A fucosylated kininogen-based biomarker panel is highly accurate for early detection hepatocellular carcinoma in patients with cirrhosis: A phase III biomarker evaluation
Anand Mehta, Mengjun Wang, Neehar D. Parikh, Nabihah Tayob, Jorge A. Marrero, Amit G. Singal

2044
Validation of GALAD for early detection of hepatocellular carcinoma in patients with cirrhosis
Neehar D. Parikh, Nabihah Tayob, Joy Lau, Cristian Saenz De Viteri, Jorge A. Marrero, Amit G. Singal

2232
Sex-specific reduction in liver damage and fat accumulation in a murine model of Lyplal1 KO
Rishel Vohnoutka, Yash Hegde, Yue Chen, Brian D. Halligan, Elizabeth K. Speliotes

2344
Upregulation of hedgehog signaling and inflammatory cytokines in the injury-induced proliferative response of extrahepatic bile duct cells
Nureen Hanisah Mohamad Zaki, Junya Shiota, Linda Samuelson, Nataliya Razumilava

2018 AASLD - November 9–13

Awards

Jad Baki
AASLD Foundation Abstract Award – Student Research Award
The award is given to a graduate or undergraduate student (i.e., has not received an MD, PhD, or equivalent doctoral degree) and is the primary contributor to the research. The award is to cover expenses related to attending the conference.

Monica Konerman, MD, MSc
AASLD Foundation Research Award – Alan Hofmann Clinical and Translational Research Award in Liver Diseases
Project Title: Optimizing lifestyle interventions as curative therapy for non-alcoholic fatty liver disease
Mentor: Anna S. Lok, MD, FAASLD

Amoah Yeboah-Korang, MD, MPH
AASLD Foundation 
Career Development Award – Advanced/Transplant Hepatology Fellowship
Project Title: Identification of drug-induced liver injury from the electronic medical record using natural language processing and ICD-10 codes
Mentor: Robert J. Fontana, MD, FAASLD

Chairs, Moderators, Panelists

Friday, November 9, 2018

Clinical Research Workshop: Researching and Applying Precision Medicine in Hepatology
Moscone Center, Room 154/156
9:00 AM – 11:00 AM
Chairs: Robert Fontana, Julia Wattacheril
Panelists: Louise Bier, David Goldstein, Yujin Hoshida, Nancy Spinner, Grace Su, Julia Wattacheril

Breakout Sessions I, II, and III
11:00 AM – 12:00 PM
Chairs: Robert Fontana, Julia Wattacheril

Saturday, November 10, 2018

SIG Program: Combined Organ Transplants
Moscone Center, Room 157/160
9:00 AM – 3:30 PM
Chairs: James Trotter, John Magee, Timucin Taner

Sunday, November 11, 2018

Transplant Plenary I
Moscone Center, Hall D
8:00 AM – 9:30 AM
Moderators: Kimberly Brown, John Magee

Parallel 16: Liver Transplantation: Optimizing the Recipient
Moscone Center, Room 153/155
2:00 PM – 3:30 PM
Moderators: Edward Doo, Pratima Sharma

Parallel 17: Healthcare Delivery, Access, and Quality
Moscone Center, Room 306/308
2:00 PM - 3:30 PM
Moderators: Elliot Tapper, Fasiha Kanwal

Special Interest Groups (SIG) Programs

Friday, November 9, 2018

The Challenge of Fontan-Associated Liver Disease
Moscone Center, Room 214/216
9:20 AM
The transplant option–decision making
John Magee

Advances in Genetics and Epigenetics in NAFLD: From Pathogenesis to Personalized Medicine
Moscone Center, Room 24/25
2:05 PM
Insights into disease pathogenesis from population genetic studies
Elizabeth Speliotes

Herbal and Dietary Supplement Induced Liver Injury: Defining the Future
Moscone Center, Room 153/155
2:40 PM
Case presentation
Robert Fontana

Saturday, November 10, 2018

Combined Organ Transplants
Moscone Center, Room 157/160
10:25 AM
Indications, patient selection and allocation policy
Pratima Sharma

Sunday, November 11, 2018

HBV Flares: Distinguishing the Good From the Bad
Moscone Center, Room 157/160
9:15 AM
Reactivation flares
Anna Lok

Alcoholic Liver Disease: Policy and Practice
Moscone Center, Room 206/208
10:35 AM
Epidemiology of AUD and ALD
Jessica Mellinger

Workshops, Courses

Friday, November 9, 2018

Clinical Research Workshop: Researching and Applying Precision Medicine in Hepatology
Moscone Center, Room 154/156
9:45 am
Applying precision medicine in imaging of liver disease
Grace Su

Clinical Research Workshop: Breakout Session III
Moscone Center, Room 154/156
11:00 am
Methodological consideration in genomics
Elizabeth Speliotes, Saul Karpan

Sunday, November 11, 2018

Hepatology Associates Course
Moscone Center, Room 153/155
11:05 am
Non-conventional approaches to management of liver disease
Robert Fontana

Monday, November 12, 2018

EMW 42 – Early Morning Workshop (Clinical)
Refer to workshop ticket for room location
6:30 AM – 7:30 AM
Management pearls in acute liver failure
Robert Fontana, Norman Sussman

EMW 44 – Early Morning Workshop (Clinical)
Refer to workshop ticket for room location
6:30 AM – 7:30 AM
Managing acute and chronic liver disease during pregnancy
Monika Sarkar, Grace Su

Abstracts – Oral Presentations

Sunday, November 11, 2018

Parallel 2: Drug-induced Liver Injury
Moscone Center, Room 206/208
8:30 am
Abstract 0038
Identification of a PTPN22 missense variant as a general genetic risk factor for drug-induced liver injury
Paul Watkins, Elizabeth Cirulli, Karen Abramson, Raul Andrade, Einar Bjornsson, Naga Chalasani, Robert Fontana, Par Hallberg, Yi-Ju Li, Maribel Lucena, Nanye Long, Miriam Molokhia, Mathew Nelson, Joseph Odin, Munir Pirmohamed, Thorunn Rafnar, Jose Serrano, Karen Stefansson, Andrew Stolz, Ann Daly, Guruprasad Aithal

Parallel 9: Metabolic and Genetic Liver Disease
Moscone Center, Room 214/216
11:00 AM
Abstract 0081
Outcomes of WTX101 treatment in a phase 2 and extension study in Wilson disease: Comparison of patients with and without cirrhosis
Michael Schilsky, Frederick Askari, Anna Czlonkowska, Peter Ferenci, Aftab Ala, Danny Bega, Jeffrey Bronstein, David Nicholl, Karl Heinz Weiss

Parallel 11: Hepatobiliary Cancer Risks
Moscone Center, Room 306/308
10:45 AM
Abstract 0092
Direct-acting antiviral therapy significantly reduces early HCC recurrence: A multicenter U.S. cohort study
Amit Singal, Neil Mehta, Nicole Rich, Caitlin Murphy, Andrea Branch, Anjana Pillai, Maarouf Hoteit, Michael Volk, Mobolaji Odewole, Steven Scaglione, Jennifer Guy, Adnan Said, Jordan Feld, Binu John, Catherine Frenette, Parvez Mantry, Amol Rangnekar, Omobonike Oloruntoba, Michael Leise, Janice Jou, Kalyan Ram Bhamidimarri, Laura Kulik, Tram Tran, Hrishikesh Samant, Renumathy Dhanasekaran, Andres Duarte-Rojo, Reena Salgia, Sheila Eswaran, Apurva Modi, Avegail Flores, Sanjaya Satapathy, Robert Wong, Annsa Huang, Suresh Misra, Myron Schwartz, Robert Mitrani, Chanda Ho, Suraj Sharma, Venkata Konjeti, Alexander Dao, Kevin Nelson, Matthew Gulau, Kelly Delarosa, Usman Rahim, Meher Mavuram, Jesse Xie, Neehar Parikh

Parallel 16: Liver Transplantation: Optimizing the Recipient
Moscone Center, Room 153/155
3:00 pm
Abstract 0125
Renal-sparing immunosuppression at time of transplant does not improve post-transplant renal outcomes
Pratima Sharma, Yihan Sun, Joslyn Neal, Jennifer Erley, James Shen, Sarah Tischer, Christopher Sonnenday, Jeong Park

Parallel 18: Pediatric Cholestasis – Basic and Clinical
Moscone Center, Room 312/314
2:45 PM
Abstract 0136
Neurocognitive outcomes in older children with biliary atresia and native liver: Results from the Childhood Liver Disease Research Network (ChiLDReN) Study
James Squires, Lisa Sorensen, Emily Fredericks, Vicky Ng, Kieran Hawthorne, Lisa Henn, Karen Murray, Kathleen Loomes, Saul Karpen, Laurel Cavallo, Jean Molleston, Jorge Bezerra, Philip Rosenthal, Robert Squires, Kasper Wang, Kathleen Schwarz, Stephen Guthery, Binita Kamath, Estella Alonso, John Magee, Ronald Sokol, Childhood Liver Disease Research Network (ChiLDReN)

Parallel 18: Pediatric Cholestasis – Basic and Clinical
Moscone Center, Room 312/314
3:00 PM
Abstract 0137
Prognostic value of serum bile acids after Kasai portoenterostomy in biliary atresia
Sanjiv Harpavat, James Heubi, Saul Karpen, Vicky Ng, Kenneth Setchell, Benjamin Shneider, Estella Alonso, Jorge Bezerra, Stephen Guthery, Kathleen Loomes, John Magee, Jean Molleston, Karen Murray, Philip Rosenthal, Averell Sherker, Robert Squires, Kasper Wang, Ronald Sokol, Childhood Liver Disease Research Network (ChiLDReN)

Parallel 20: Ongoing Benefits of HCV Therapy
Moscone Center, Room 157/160
5:30 PM
Abstract 0149
Improvements in symptoms shortly following viral cure for chronic hepatitis C: A large multi-site clinical cohort study
Donna Evon Paul Stewart, Jipcy Amador, Nancy Reau, Souvik Sarkar, Rajender Reddy, Bryce Reeve, Anna Lok, Richard Sterling, Carol Golin, Marina Serper, Joseph Lim, Adrian Di Bisceglie, Michael Fried, David Nelson

Parallel 24: Genomics Link to Disease Phenotypes
Moscone Center, Room 22/23
5:45 pm
Abstract 0174
Plasma glycoprotein profile in liver transplant recipients reveals enrichment of inflammatory proteins with advancing chronic kidney disease
Pratima Sharma, Pradeep Kayampilly, Venkat Basrur, Raji Menon, Hellan Kwon, Subramaniam Pennathur

Parallel 25: Health Economics and Patient Centered Outcomes
Moscone Center, Room 306/308
5:00 PM
Abstract 0177 - AASLD Foundation Abstract Award - Student Research Award
Frailty and opiate use are strongly correlated with quality of life in patients with cirrhosis: A prospective study of 300 outpatients without hepatic encephalopathy
Jad Baki, Jane Wong, Neehar Parikh, Anna Lok, Elliot Tapper

Monday, November 12, 2018

Presidential Plenary – Clinical Science
Moscone Center, Hall D
8:30 AM
Abstract 0015
Predictors of outcome in children with biliary atresia surviving with native liver at two years of age
Veena Venkat, Vicky Ng, John Magee, Wen Ye, Kieran Hawthorne, Sanjiv Harpavat, Karen Murray, Kasper Wang, Jean Molleston, Henry Lin, Lee Bass, Nisreen Soufi, Cara Mack, Jorge Bezerra, Stephen Guthery, Averell Sherker, Philip Rosenthal, Ronald Sokol, Saul Karpen, Childhood Liver Disease Research Network (ChiLDReN)

Parallel 32: Complications of Cirrhosis III
Moscone Center, Room 206/208
11:15 AM
Abstract 0220
Incidence and predictors of hepatic encephalopathy in a population-based cohort of older Americans with cirrhosis: Role of opiates, benzodiazepines and proton-pump inhibitors (PPIs)
Elliot Tapper, James Henderson, Jad Baki, Neehar Parikh, Anna Lok

Parallel 33: HCV Therapy in Unique Populations
Moscone Center, Room 154/156
11:15 am
Abstract 0226
High efficacy of glecaprevir/pibrentasvir in patients with chronic HCV GT1 infection who failed prior treatment with NS5A-inhibitor plus sofosbuvir regimens
Mark Sulkowski, Anna Lok, Ira Willner, Rajender Reddy, Mitchell Shiffman, Mohamed Hassan, Brian Pearlman, Federico Hinestrosa, Ira Jacobson, Giuseppe Morelli, Joy Peter, Monika Vainorius, Larry Michael, Michael Fried, Gary Wang, Yiran Hu, Jens Kort, David Nelson

Abstracts – Poster Presentations

Moscone Center, Hall C – Poster Hall

Friday, November 9, 2018: 8:00 AM – 5:30 PM

Drug Metabolism and Toxicity
Abstract 0334
Asparaginase-induced hepatotoxicity
Natasha Kamal, Niharika Samala, Christopher Koh, Robert Fontana, Andrew Stolz, Francisco Durazo, Paul Hayashi, Jay Hoofnagle

Health Care Delivery, Access, and Quality
Abstract 0461
Women with cirrhosis are at increased risk of hospitalization compared to men
Jessica Rubin, Marie Sinclair, Robert Rahimi, Elliot Tapper, Jennifer Lai

Health Care Delivery, Access, and Quality
Abstract 0477
Advanced care planning in end stage liver disease: opportunity for improvement
Meaghan Trainor, Tammy Ellies, Pratima Sharma

Health Care Delivery, Access, and Quality
Abstract 0518
Opioid and benzodiazepine use in alcoholic cirrhosis patients is common and associated with increased hospital admissions
Jessica Mellinger, Gerald Winder, Kerby Shedden, Anne Fernandez, Allison Lin, Michael Volk, Frederic Blow, Anna Lok

Hepatitis C Therapeutics: Approved Agents
Abstract 0612
Patient-reported symptom experiences are heterogeneous during direct acting antiviral therapy for chronic hepatitis C: A prospective real-world cohort study
Souvik Sarkar, Donna Evon, Jipcy Amador, Paul Stewart, Anna Lok, Richard Sterling, Bryce Reeve, Marina Serper, Rajender Reddy, Nancy Reau, Joseph Lim, Carol Golin, David Nelson, Adrian Di Bisceglie, Michael Fried

Hepatitis C Therapeutics: Approved Agents
Abstract 0653
Efficacy and safety of 8 weeks of glecaprevir/pibrentasvir in treatment-naïve adults with HCV genotype 1–6 and aspartate aminotransferase to platelet ratio index (APRI) ≤1
Robert Fontana, Sabela Lens, Stuart McPherson, Magdy Elkhashab, Krum Katzarov, Ana Gabriela Pires, Zhenyi Xue, Roger Trinh, Lino Rodrigues Jr., Ariel Porcalla, Stefan Zeuzem

Hepatotoxicity and Drug Induced Liver Injury
Abstract 0716
The role of HEV infection in U.S. patients with suspected drug induced liver injury
Robert Fontana, Paul Hayashi, Jay Hoofnagle, Huiman Barnhart, Ronald Engle, Patrizia Farci

Hepatotoxicity and Drug Induced Liver Injury
Abstract 0721
Liver injury during pembrolizumab immunotherapy is associated with a lower rate of tumor remission and higher rate of mortality
Russell Dolan, Irene Tsung, Leslie Fecher, Christopher Lao, Robert Fontana

Hepatotoxicity and Drug Induced Liver Injury
Abstract 0729A
Quantitation of catechin content in herbal and dietary supplements implicated in human hepatotoxicity: A preliminary report from the Drug Induced Liver Injury Network (DILIN)
Victor Navarro, Bharathi Avula, Yanhong Wang, Huiman Barnhart, Manisha Verma, Ikhlas Khan, Jawad Ahmad, Herbert Bonkovsky, Naga Chalasani, Robert Fontana, Leonard Seeff, Jose Serrano, Andrew Stolz, Drug Induced Liver Injury Network

Patient Centered Outcomes Research
Abstract 0756
Liver disease is associated with falls and fractures: A nationally-representative cohort study
Maria Camila Perez-Matos, Gordon Jiang, Elliot Tapper

Patient Centered Outcomes Research
Abstract 0758
Use of prescription opioid and benzodiazepines is two-folds higher among patients with cirrhosis compared to other forms of chronic disease
Monica Konerman, Mary Rogers, Brooke Kenney, Brahmajee Nallamothu, Amit Singal, Pratima SharmaElliot TapperSameer SainiAkbar Waljee

Patient Centered Outcomes Research
Abstract 0781
Awareness and knowledge of non-alcoholic fatty liver disease among office employees in Beijing, China
Wei Zhang, Samantha Chao, Stephanie Chen, Huiying Rao,  Rui Huang,  Lai Wei, Anna Lok

Saturday, November 10, 2018: 2:00 PM – 7:30 PM

Clinical and Translational Hepatobiliary Cancer I
Abstract 0904
A high proportion of hepatocellular carcinoma have indolent growth patterns
Nicole Rich, Binu John, Neehar Parikh, Christopher Hernandez, Jorge Marrero, Mobolaji Odewole, Latha Sundaram, Venkata Konjeti, Shivangi Sharma, Amit Singal

Clinical and Translational Hepatobiliary Cancer I
Abstract 0908
Cost-effectiveness of sorafenib versus selective internal radiation therapy for patients with advanced hepatocellular carcinoma
Neehar Parikh, Amit Singal, Laura Kulik, David Hutton

Complications of Cirrhosis I
Abstract 0962
Limited progress in hepatorenal syndrome (HRS) reversal and survival 2002–2016
Mary Thomson, Arthur Taylor, Pratima Sharma, Anna Lok, Elliot Tapper

Liver Transplantation: Management and Outcomes
Abstract 1205
Prevalence and patterns of prescription opioid use before and after liver transplantation
David Cron, Monica Konerman, Ali Hammoud, Jay Lee, Akbar Waljee, Chad Brummet, Jennifer Waljee, Michael Englesbe, Christopher Sonnenday

Sunday, November 11, 2018: 8:00 AM – 5:30 PM

Alcoholic Liver Disease: Clinical and Experimental
Abstract 1400
Women with alcoholic liver disease are less likely to be listed for liver transplantation
Alisa Likhitsup, Lisa McElroy, Jessica Mellinger, Naba Saeed, Ammar Hassan, Gerald Winder, Christopher Sonnenday, Robert Fontana

Alcoholic Liver Disease: Clinical and Experimental
Abstract 1401
Alcoholic liver disease has rapidly emerged as the leading indication for liver transplant evaluation
Alisa Likhitsup, Jessica Mellinger, Lisa McElroy, Naba Saeed, Ammar Hassan, Gerald Winder, Christopher Sonnenday, Robert Fontana

Cholangiocyte Biology – Poster of Distinction
Abstract 1449
HH signaling regulates extrahepatic bile duct epithelial cell proliferation after injury
Junya Shiota, Nureen Hanisah Mohamad Zaki, Juanita Merchant, Linda Samuelson, Nataliya Razumilava

Cholangiocyte Biology
Abstract 1452
An important role for Wnt signaling in cholangiocyte regeneration in extrahepatic bile ducts
Nataliya Razumilava, Junya Shiota, Nureen Hanisah Mohamad Zaki, Juanita L Merchant, Linda Samuelson

HCV Diagnostics, Epidemiology and Natural History
Abstract 1616
Prevalence and predictors of medication non-adherence in a multi-center cohort treated with hepatitis C direct-acting antivirals: Results from the Patient-Reported Outcomes Project (PROP-UP)
Marina Serper, Donna Evon, Paul Stewart, Anna Lok, Jipcy Amador, Bryce Reeve, Carol Golin, Michael Fried, Rajender Reddy, Richard Sterling, Souvik Sarkar, Adrian Di Bisceglie, Joseph Lim, David Nelson, Nancy Reau

Monday, November 12, 2018: 8:00 AM – 5:30 PM

NAFLD and NASH: Clinical II
Abstract 2271
Fat accumulation, liver damage and metabolic abnormalities in Chinese NAFLD patients with moderate/severe hepatic steatosis
Wei Zhang, Elizabeth Ann Wu, Yi Wang, Rui Huang, Sravanthi Kaza, Anqi Li, Chao Sun, Huiying Rao, Lai Wei, Grace Su, Anna Lok

NAFLD and NASH: Clinical II
Abstract 2279
The high economic burden of non-alcoholic steatohepatitis (NASH) compared to matched controls: Results from the 2016 US National Health and Wellness Survey (NHWS)
Elliot Tapper, Maria-Magdalena Balp, Nancy Krieger, Raymond Przybysz, Nate Way, Jennifer Cai, Dion Zappe, Sarah Mckenna, Garth Wall, Nico Janssens

NAFLD and NASH: Clinical II
Abstract 2280
Lifestyle modification in patients with non-alcoholic fatty liver disease: The main barrier is motivation to change, not knowledge
Lisa Glass, Jane Wong, Robert Fontana, Elliot Tapper, Michael Volk, Anna Lok, Monica Konerman

NAFLD and NASH: Clinical II
Abstract 2335
Survey of non-alcoholic fatty liver disease knowledge and nutrition and physical activity patterns among the general public in Beijing, China
Stephanie Chen, Samantha Chao, Monica Konerman, Wei Zhang, Huiying Rao, Elizabeth Ann Wu, Andrew Lin, Lai Wei, Anna Lok