AASLD 2020

The American Association for the Study of Liver Diseases (AASLD) is the leading organization of scientists and healthcare professionals committed to preventing and curing liver disease.

This year, our faculty continued to earn prestigious AASLD awards and to play key roles in the leadership of AASLD. Please see a daily compilation of the main sessions during which our faculty, fellows, and researchers are presenting at The Liver Meeting Digital Experience, November 13–16, 2020.

AASLD Foundation Awards

Clinical, Translational and Outcomes Research Award

Vincent Chen, MD
Project Title: Integrating genetic and environmental factors to predict risk of non-alcoholic fatty liver disease
Mentor: Elizabeth K. Speliotes, MD, PhD, MPH

Pilot Research Award

Jun Wu, PhD
Project Title: A novel cholinergic circuitry in hepatic regulation
Mentor: Liangyou Rui, PhD

Leadership Positions

Councilor and AASLD President in 2025

We congratulate Grace Su, MD, FAASLD on her election as Councilor for the term 2021 – 2026. She will become the AASLD President in 2025.

AASLD and SIG Committees, Journal Editorial Boards

Patricia P. Bloom, MD
Communications and Technology Committee
Trainee Member

Robert J. Fontana, MD, FAASLD
Nominating Committee
Member (Elected)
Hepatology Communications
Editorial Board
Hepatology Communications
Editorial Board

Anna S. Lok, MD, FAASLD
Hepatitis B SIG
Steering Committee
Hepatology
Editorial Board

Jessica L. Mellinger, MD, MSc
Alcohol-associated Liver Disease SIG
Steering Committee
Clinical Liver Disease
Editorial Board
Hepatology Communications
Editorial Board

Pratima Sharma, MD, MS
Acute on Chronic Liver Failure SIG
Steering Committee
Liver Transplantation and Surgery SIG
Steering Committee
Public Policy Committee
Member
Liver Transplantation
Associate Editor

Elizabeth K. Speliotes, MD, PHD, MPH
Research Awards Committee
Member

Grace L. Su, MD, FAASLD
Annual Meeting Education Committee
Chair
Maintenance of Certification (MOC) Committee
Member
Scientific Program Committee
Member

Elliot B. Tapper, MD
Cirrhosis Quality Collaborative (CQC)
Steering Committee
Practice Metrics Committee
Chair-Elect
Public Health / Health Care Delivery SIG
Steering Committee
Hepatology
Editorial Board
Hepatology Communications
Editorial Board

Monica A. Tincopa, MD, MSc
Clinical Research Committee
Member

The Liver Meeting Program - Chairs, Moderators

Saturday, November 14, 2020

Emerging Trends Symposium
Artificial Intelligence (AI) in Hepatology
9:00 – 10:30 am
Co-chair: Grace L. Su

Parallel Session 2: Liver Transplantation: Immunosuppression/Outcomes/Complication
2:00 – 3:30 pm
Moderator: Pratima Sharma

Sunday, November 15, 2020

COVID-19 and the Liver Symposium
2:00 – 3:30 pm
Moderator: Robert J. Fontana 

Parallel Session 16: Hepatobiliary Neoplasia: Experimental and Novel Diagnostic/Imaging
5:30 – 7:00 pm
Moderator: Grace L. Su

Parallel Session 17: Hepatotoxicity
5:30 – 7:00 pm
Moderator: Robert J. Fontana

Monday, November 16, 2020

Parallel Session 20: Hepatobiliary Neoplasia: Clinical
9:00 – 10:30 am
Moderator: Neehar Parikh

Special Session

Conversation with our Nobel Laureates (2020 Nobel Laureates in Physiology and Medicine, Harvey Alter, MD, Michael Houghton, PhD, Charles Rice, PhD)
12:00-1:00 pm
Moderators: Jorge Bezerra, Raymond Chung, Anna Lok

Postgraduate Course

Saturday, November 14, 2020

Part 1. Paradigm Shifts in Hepatology: Rethinking Conventional Wisdom
8:00 am – 12:00 pm

In Session I Toward a biopsy-free world
Elliot B. Tapper

In Session V HBV and HDV: Can we now talk about cure?
Anna S. Lok

Pre-Events, Symposiums, Meet the Experts, Workshops

Friday, November 13, 2020

Pre-Events

Social Media in Hepatology

How to maintain professionalism on social media
Patricia P. Bloom

Value-based Medicine in Hepatology

Valued-based Hepatology Care Post COVID-19
Elliot B. Tapper, MD

Saturday, November 14, 2020

Emerging Trends Symposium

9:00 – 10:30 am

9:50 – 10:10 am
Use for deep learning in imaging of patients with liver disease
Grace L. Su

Workshops

Clinical Research Workshop
10:30 am – 12:00 pm

Qualitative research methodologies to understand barriers in alcohol use disorder
Jessica L. Mellinger

Career Development Workshop
2:00 pm – 3:30 pm

How to be a good mentee and identify mentors/sponsors to launch your career
Elliot B. Tapper

Sunday, November 15, 2020

Meet the Experts

12:00-1:00 pm

Management of substance abuse disorders for the hepatologist
Jessica L. Mellinger

Hepatitis B: The treatment pipeline
Anna S. Lok

COVID-19 and the Liver Symposium

2:00 – 3:30 pm

3:05 – 3:20 pm
Impact of health disparities in the treatment and outcomes of patients with COVID-19
John Carethers

Oral Abstract Presentations

Saturday, November 14, 2020

Parallel Session: Hepatitis B: Therapeutics (Established)
9:00 – 10:30 am

9:00 am
Abstract #19
Randomized trial of 192 weeks of tenofovir with or without peginterferon alfa for the first 24 weeks followed by protocolized withdrawal in adults with chronic hepatitis B
Norah Terrault, Anna S Lok, Abdus Wahed, David KH Wong, Mandana Khalili, Michael W Fried, Daryl Lau, Marc G Ghany, Richard K Sterling, Adrian M Di Bisceglie, Robert P Perrillo, Mauricio Lisker-Melman, Stewart Cooper, Raymond T Chung, Keyur Patel, Lewis R Roberts, Charles Landis, Mohamed A Hassan, Christopher A Aoki, Steve Belle, Harry LA Janssen

Sunday, November 15, 2020

Presidential Plenary – Clinical and Outcomes Discoveries
9:00 – 10:30 am

AASLD Foundation Abstract Award
Abstract #9
Predictors of outcomes of COVID-19 in patients with chronic liver disease: US multi-center study
Nia Adeniji, Donghee Kim, Nyan L Latt, Sonal Kumar, Patricia P Bloom, Elizabeth S Aby, Ponni V. Perumalswami, Marina Roytman, Michael Li, Alexander S Vogel, Andreea M Catana, Kara Wegermann, Rotonya M Carr, Costica Aloman, Vincent Chen, Akshata Moghe, Veronica Nguyen, Brett Sadowski, Atoosa Rabiee, Winston Dunn, Kenneth D. Chavin, Kali Zhou, Blanca Lizaola-Mayo, Jose D Debes, Tzu-Hao Lee, Andrea D Branch, Kathleen Viveiros, Walter W Chan, David M Chascsa, Paul Y Kwo, Renumathy Dhanasekaran

Parallel Session 17: Hepatotoxicity
5:30 – 7:00 pm

Abstract #117
HLA risk alleles associated with drug induced liver injury due to antiepileptic drugs
Paola Nicoletti, Yi-Ju Li, Elizabeth J Phillips, Andrew Dellinger, Huiman Barnhart, Robert J Fontana, Herbert L Bonkovsky, Naga P Chalasani, and for the Drug Induced Liver Injury Network (DILIN)

Monday, November 16, 2020

Parallel Session 19: Acute/Acute on Chronic Liver Failure
9:00 am

Abstract #127
Prediction of survival in adults with ALF and non-acetaminophen ALI using the 13C methacetin breath test: Results of a prospective, multicenter trial
Robert J Fontana, R Todd Stravitz, Valerie L Durkalski-Mauldin, James Hanje, Bilal Hameed, David G Koch, Daniel R Ganger, Jody C Olson, Iris W Liou, Brendan M McGuire, Kristen Clasen, William M Lee

Parallel Session: Hepatitis B: Non-Therapy
10:30 am – 12:00 pm

Abstract #157
Do novel assays improve phenotypic characterization of adults with chronic hepatitis B?
Marc G Ghany, Wendy King, Mauricio Lisker-Melman, Gavin Cloherty, Mandana Khalili, Raymond T Chung, Norah Terrault, William M Lee, Daryl Lau, Harry LA Janssen, Anna S Lok, Richard K Sterling, and on behalf of the HBRN

Oral Session
Abstract #62
Association of serum biomarkers with liver stiffness assessed by transient elastography in 330 children with cholestatic liver disease
Daniel H Leung, Sridevi Devaraj, Nathan P Goodrich, Xinpu Chen, Deepthi B Rajapakshe, Wen Ye, Victor Andreev, Charles Minard, Danielle Guffey, Jean Pappas Molleston, Lee M Bass, Saul J Karpen, Binita M Kamath, Kasper S Wang, Shikha S Sundaram, Philip Rosenthal, Patrick James McKiernan, Kathleen M Loomes, M Kyle Jensen, Simon P Horslen, Jorge A Bezerra, John C Magee, Robert Merion, Ronald J Sokol, Benjamin L Shneider

Oral Session
Abstract #73
The relationship between physical frailty and impaired cognition in patients with cirrhosis
Kacey Berry, Andres Duarte-Rojo, Joshua D Grab, Michael A Dunn, Brian J Boyarsky, Betsy C Verna, Matthew R Kappus, Michael Volk, Mara McAdams-DeMarco, Dorry L Segev, Daniel R Ganger, Daniela P Ladner, Monica A Tincopa, Robert S Rahimi, Jennifer Cindy Lai

Oral Session
Abstract #339
Prognostic value of serum bile acids after achieving bile flow with the Kasai portoenterostomy in biliary atresia (formerly a poster abstract) okay to delete?
Sanjiv Harpavat, Kieran Hawthorne, Benjamin L Shneider, Lisa Henn, Charlotte Beil, Saul J Karpen, Vicky Lee Ng, Kenneth DR Setchell, Estella M Alonso, Jorge A Bezerra, Stephen L Guthery, Simon P Horslen, Binita M Kamath, Kathleen M. Loomes, Patrick James McKiernan, John C Magee, Robert M Merion, Jean Pappas Molleston, Philip Rosenthal, Richard J Thompson, Kasper S Wang, Ronald J Sokol, James E Heubi

Oral Session
Abstract #374
Multiomic integrated molecular landscape of hyperammonemia show a time-dependent change in chromatin accessibility and the translatome of sarcopenia of cirrhosis
Nicole M Welch, Avinash Kumar, Shashi S Singh, Saurabh Mishra, Jinendiran Sekar, Annette Bellar, Lin Ling, Dongmei Zhnag, Belinda Willard, Michelle Longworth, Yatrik Shah, Srinivasan Dasarathy

Posters

Acute/Acute on Chronic Liver Failure

Abstract #184
Bleeding, thrombosis, and outcome according to rotational thromboelastometry (ROTEM) parameters in patients with acute liver injury/failure
R Todd Stravitz, Robert J Fontana, Caitlyn Meinzer, Valerie L Durkalski-Mauldin, Adam James Hanje, Jody C Olson, David G Koch, Bilal Hameed, Michael L Schilsky, Brendan M McGuire, Daniel R Ganger, Iris W Liou, Constantine J Karvellas, Ton Lisman, Kristen Clasen, William M Lee, ALF Study Group

Abstract #186
CPS1 is a prognostic biomarker in patients with acute liver failure
Raymond Kwan, Min-Jung Park, Sujith VW Weerasinghe, Zemin Su, William M Lee, Valerie L Durkalski-Mauldin, Robert J Fontana, M Bishr Omary

AASLD Presidential Poster of Distinction
Abstract #203
Trends in severe acute idiosyncratic drug induced liver injury: An update from the ALFSG Registry
Ashwin Rao, Jody A Rule, Bilal Hameed, Daniel R Ganger, Robert J Fontana, William M Lee

Alcohol Associated Liver Disease: Clinical and Experimental

Abstract #276
Provider attitudes and practices for alcohol screening, treatment and education in patients with liver disease
Jessica L Mellinger, Gene Y Im, Adam Winters, Elizabeth S Aby, Zurabi Lominadze, Michael R Lucey, John P Rice, Loretta Jophlin, Juan Pablo Arab, Aparna Goel, Courtney Sherman, Deepika Devuni, Richard Parker, Po-Hung Chen, Sandeep Sidhu, Winston Dunn, Gyongyi Szabo, Ashwani K Singal, Vijay Shah

COVID-19 and the Liver

Abstract #430
COVID-19 outcomes among solid organ transplant recipients: a matched case-control study
Pratima Sharma, Vincent Chen, Christopher M Fung, Jonathan P Troost, Vaiibhav N Patel, Michael Combs, Silas P Norman, Puneet Garg, Monica Colvin, Keith Aaronson, Christopher J Sonnenday, Jonathan Golob, Emily C Somers, Mona M Doshi

Abstract #438
Hepatic steatosis is associated with elevated alanine aminotransferase (ALT) but not elevated bilirubin or hepatic decompensation in patients with novel coronavirus disease 2019 (COVID-19)
Ihab A Kassab, Fadi Hawa, Jeffrey A Berinstein, Calen A Steiner, Kevin D Platt, Jeremy Louissaint, Chia-Yang Hsu, Chanakyaram A Reddy, Naresh T Gunaratnam, Vincent Chen, Pratima Sharma

Abstract #439
Hepatic steatosis is associated with increased disease severity in patients with novel coronavirus 2019 (COVID-19)
Fadi Hawa, Ihab A Kassab, Jeffrey A Berinstein, Calen A Steiner, Kevin D Platt, Jeremy Louissaint, Chia-Yang Hsu, Chanakyaram A Reddy, Naresh T. Gunaratnam, Vincent Chen, Pratima Sharma

Abstract #471
Patterns and predictors of liver injury in liver transplant recipients with coronavirus disease 2019 (COVID-19)
Atoosa Rabiee, Brett Sadowski, Nia Adeniji, Veronica Nguyen, Akshata Moghe, Ponni V Perumalswami, Nyan L Latt, Sonal Kumar, Costica Aloman, Maria-Andreea Catana, Patricia P Bloom, Kenneth D Chavin, Rotonya M Carr, Winston Dunn, Vincent Chen, Elizabeth S Aby, Jose D Debes, Renumathy Dhanasekaran, COLD Consortium

Genomics and Precision Medicine

Abstract #606
Polygenic risk scores for transaminases are associated with hepatic steatosis and cirrhosis
Vincent Chen, Xiaomeng Du, Yanhua Chen, LC Stetson, Elizabeth K Speliotes

Cirrhosis

Abstract #627
A telemonitoring system is feasible for outpatient cirrhotic ascites management
Patricia P Bloom, Zoe Reinus, Jessica Shay, Jasmine Ha, James M Richter

Health Services Research: Patient Centered Outcomes Research

Abstract #703
Cost-effectiveness of alcohol cessation interventions among patients with alcohol-related cirrhosis
Anton Avencena, Nicholas Miller, Sarah Uttal, David Hutton, Jessica L Mellinger

Hepatitis B: Epidemiology, Prevention, Natural History

Abstract #773
Symptoms of chronic liver disease are associated with higher risk of adverse clinical outcomes: A longitudinal study in a large cohort of North American adults with chronic hepatitis B
Donna M Evon, Hsing-Hua Lin, Robert J Fontana, Mandana Khalili, Colina K Yim, Abdus Wahed, Jay H Hoofnagle, Hepatitis B Research Network (HBRN) 

Hepatobiliary Neoplasia: Clinical

AASLD Presidential Poster of Distinction
Abstract #1057
Incidence and predictive factors of hepatocellular carcinoma (HCC) in a prospectively followed US cohort of patients at risk: Hepatocellular carcinoma early detection strategy (HEDS) study
K Rajender Reddy, Neehar D Parikh, Lewis R Roberts, Myron E Schwartz, Mindie H Nguyen, Alex Befeler, Stephanie Page-Lester, Dale McLerran, Sudhir Srivastava, Jo Ann Rinaudo, Ziding Feng, Jorge A Marrero 

Hepatotoxicity: Pathogenesis and Mechanisms; Drug Metabolism, Toxicity, and Therapeutics; Predictors of Drug Toxicity

Abstract #1181
A revised electronic version of RUCAM for the diagnosis of drug induced liver injury
Paul H Hayashi, M Isabel Lucena, Robert J Fontana, Einar Bjornsson, Guruprasad P Aithal, Huiman Barnhart, A Gonzalez-Jimenez, Qinghong Yang, Jiezhun Gu, Raul J Andrade, Jay H Hoofnagle, DILIN Investigators

Abstract #1185
Checkpoint inhibitor hepatotoxicity is characterized by peripheral eosinophilia and hepatocellular or mixed injury at onset but a low risk of liver failure during follow-up
Robert J Fontana

Abstract #1194
Identifying cases of idiosyncratic drug-induced liver injury using ICD-10 codes for drug toxicity/poisoning and liver failure
Jeremy Louissaint, Ihab A Kassab, Amoah Yeboah-Korang, Robert J Fontana

Liver Transplantation

Abstract #1317
Automated measurements of body composition in abdominal CT scans using deep learning can predict survival in patients with cirrhosis
Winnie Zou, Binu Enchakalody, Nidhi Shah, Peng Zhang, Grace L Su

Abstract #1342
Factors associated with cardiovascular events after simultaneous liver kidney transplant (SLKT): Results from the U.S. multicenter SLKT Consortium
Jennifer Jo, Dyanna Gregory, Jasmine Sinha, Jiaheng Xie, Min ZhangJohn C Magee, Pranab M. Barman, Yuval Patel, Aaron Schluger, Kara Walter, Scott W Biggins, Giuseppe Cullaro, Randi Wong, Jennifer Cindy Lai, Elizabeth C Verna, Pratima Sharma, Lisa B VanWagner

Abstract #1389
Predictors of length of stay and death for simultaneous liver–kidney transplant (SLKT) index admission: Results from the US multicenter SLKT Consortium
Pranab M Barman, Jiaheng Xie, Min Zhang, Jennifer Jo, Jasmine Sinha, Aaron Schluger, Kara Walter, Scott W Biggins, Giuseppe Cullaro, Randi Wong, Jennifer Cindy Lai, Lisa B. VanWagner, John C Magee, Betsy C Verna, Yuval Patel, Pratima Sharma

Abstract #1402
Risks of early hospitalization after simultaneous liver and kidney transplant (SLKT): Analysis from the United States (US) multicenter SLKT Consortium
Pratima SharmaJiaheng Xie, Min Zhang, Pranab M Barman, John C Magee, Jennifer Jo, Jasmine Sinha, Aaron Schluger, Kara Walter, Giuseppe Cullaro, Randi Wong, Scott W Biggins, Jennifer Cindy Lai, Lisa B VanWagner, Betsy C Verna, Yuval Patel

Abstract #1419
The relationship between frailty and etiology of cirrhosis: from the multi-center functional assessment in liver transplantation (FRAILT) study
Chelsea Xu, Yara Mohamad, Matthew R Kappus, Brian J Boyarsky, Daniel R Ganger, Michael Volk, Robert S Rahimi, Andres Duarte-Rojo, Mara McAdams-DeMarco, Dorry L Segev, Daniela P Ladner, Betsy C Verna, Monica A Tincopa, Michael A Dunn, Jennifer Cindy Lai

Liver Disease and Cystic Fibrosis

Abstract #1457
Characteristics and clinical liver disease in children with sonographic nodular liver (sonic) in cystic fibrosis
Jean Pappas Molleston, Wen Ye, Sarah Jane Schwarzenberg, Alvin J Freeman, Joseph Palermo, Alexander Weymann, Estella M Alonso, Wikrom Karnsakul, Karen F Murray, John C Magee, Daniel H Leung, Michael R Narkewicz,

Nonalcoholic Fatty Liver Disease

Abstract #1565
A pragmatic clinical prognostic classification suitable for universal application stratifies patients with NAFLD by risk of mortality and both hepatic and extrahepatic outcomes
Arun J Sanyal, Meng Wang, Kenneth Cusi, Alfred Sidney Barritt IV, Mark Dhinesh Muthiah, Stephanie Watkins, K Rajender Reddy, Roberto J Firpi, Paul J. Thuluvath, Kalyan Ram Bhamidimarri, Anna S Lok, Michael W Fried 

Abstract #1569
Association of nonalcoholic fatty liver disease with cognition and brain volumes in the ACCORD randomized clinical trial
Neal Parikh
, Cenai Zhang, Russell Rosenblatt, Sonal Kumar, Elliot B Tapper, Hooman Kamel, Costantino Iadecola

Nonalcoholic Steatohepatitis

Abstract #1574
Burden of stage 2/3 fibrosis associated with nonalcoholic steatohepatitis: A cost of illness analysis
Darshini Shah, Elliot B Tapper, Kate Burslem, Steve Marcus, Jalpa A Doshi 

Abstract #1595
Heterogeneous documentation and poor concordance of NASH pathology may limit its clinical utility in real-world practice
Hannah Kim, Michael O Idowu, Richard C. Zink, Andrea Mospan, Michael Roden, Philip N Newsome, Anna S Lok, Paul J Thuluvath, Jawahar L Taunk, Michael W Fried, Arun J Sanyal, Alfred Sidney Barritt IV

Other Portal Hypertension Complications

Abstract #1743
Comparison of seven noninvasive models for predicting decompensation and hospitalization in patients with cirrhosis
Chia-Yang Hsu, Teh-Ia Huo, Neehar D. Parikh, Elliot B Tapper

AASLD Presidential Poster of Distinction
Abstract #1758
Hepatic encephalopathy is associated with a distinct speech pattern
Patricia P Bloom, Ashwini Arvind, Michael Daidone, Jessica Robin, Mengdan Xu, Anoopum S Gupta, Raymond T Chung

Abstract #1769
Noninvasive liver indices predict early decompensation in patients with newly diagnosed cirrhosis
Chia-Yang Hsu, Neehar D Parikh, Elliot B Tapper, Teh-Ia Huo

Abstract #1771
Nonselective beta-blocker use as an independent predictor of total number of hepatic encephalopathy-related admissions in patients with cirrhosis
Mohammad Amin Fallahzadeh, Sumeet K Asrani, Elliot B Tapper, Giovanna Saracino, Daniel Bizzarri, Robert S Rahimi

Abstract #1776
Prophylaxis and treatment of hepatic encephalopathy improves health-related quality of life, sleep, and social functioning
Andrew Moon, Hannah Kim, Jennifer S Walker, Charles Poole, Alfred Sidney Barritt IV, Elliot B Tapper

Abstract #1826
Morbidity and mortality following emergent or non-emergent umbilical hernia surgery in a national sample of US veterans with or without cirrhosis
Kay Johnson, Kira Newman, Kristin Berry, Pamela Green, Peter C Wu, Paul B Cornia, Lauren A. Beste, Kamal Itani, Alex HS Harris, Patrick S Kamath, George Ioannou