Digestive Disease Week 2021

DDW 2021 Michigan Medicine Highlights  

See below for the Michigan Medicine Division of Gastroenterology and Hepatology faculty and fellows participating in the 2021 Digestive Disease Week® (DDW) taking place May 21-23, 2021. Download The GI Digest for a printer friendly version.

Friday, May 21

10:00 am | AASLD Research Forum
COVID-19 and the Liver
Moderator: Robert Fontana

10:29 am | ASGE Topic Forum
Endoluminal functional lumen imaging probe (EndoFLIP) can be used to assess severity of gastric sleeve stenosis
Jessica X. Yu, Kevin D. Platt, Sean Bhalla, Lydia Watts, Allison R. Schulman

11:00 am | AASLD Research Forum
Risk of progression to hepatocellular carcinoma in patients with indeterminate (LI-RADS 3) observations
Ashwini Arvind, Timothy A. Zaki, Takeshi Yokoo, David T. Fetzer, Travis Browning, Nicole E. Rich, Jorge A. Marrero, Hao Zhu, Adam Yopp, Yujin Hoshida, Purva Gopal, Neehar D. Parikh, Amit G. Singal

11:10 am | ASGE Topic Forum | Advances and Refinements in Bariatric Endoscopy
Roundtable Discussion: Tips and tricks for endoscopic therapy to treat weighty regain or complications after bariatric surgery
Allison R. Schulman, Erik B. Wilson

11:30 am | DDW Networking
Grand Rounds: Gastrointestinal Oncology
Moderator: Michelle Anderson

1:00 pm | AGA Research Forum
Molecular and Immune Profiling of GI Cancers
Moderator Introduction: Yatrik M. Shah

1:03 pm | AGA Clinical Symposium
Path to partnership in private practice
John I. Allen

1:15 pm | AASLD Research Forum
Specificity and positive predictive value of international classification of diseases-10 diagnosis codes for cirrhosis
Isabel J. Moran, Daniel A. Burkholder, Jacob V. DiBattista, Vincent L. Chen

1:16 pm | AGA Research Forum
How often does Squatty Potty correct an abnormal balloon expulsion test in chronically constipated patients?
Eden Koo, Gabrielle Ezell, William D. Chey, Jason Baker, Moira Armstrong, Borko Nojkov

1:16 pm | AGA Research Forum
Working smarter not harder: Using simulation to evaluate evidence-based strategies to offload colonoscopy backlogs related to COVID-19
Adam VanDeusen, Sameer Saini, Eve Kerr, Amy Cohn, Timothy Hofer, Andrew Gawron, Jason Dominitz, Jacob Kurlander

1:26 pm | AGA Research Forum
A prediction model for metachronous advanced neoplasia after colorectal polypectomy utilizing polyp, demographic, and quality factors
Samir Gupta, Ranier Bustamante, Ashley Earles, Joshua Demb, Hanin Yassin, Maria Elena Martinez, Sameer Dev Saini, Deborah A. Fisher, Andrew J Gawron, Tonya R. Kaltenbach, Olga V Patterson, Scott L DuVall, Karen Messer, Lin Liu

1:54 pm | AGA Research Forum
Efficacy and safety of mirikizumab after 52-weeks maintenance treatment in patients with moderate-to-severe Crohn’s disease
Bruce E. Sands, William J. Sandborn, Laurent Peyrin-Biroulet, Peter D.R. Higgins, Fumihito Hirai, Vipul Jairath, Geert D’Haens, Maria T. Abreu, Ruth Belin, Elisa Gomez Valderas, Debra Miller, April N Naegeli, Vipin Arora, Paul Pollack, Jay Tuttle, Toshifumi Hibi

1:58 pm | AGA Research Forum
Demographic and clinical factors associated with severe abdominal bloating in FGIDs: Female sex, constipation, and dyspepsia, but not psychological factors are associated with severe bloating
Catherine Parkhurst Gardiner, Prashant Singh, Sarah Ballou, Rafla Hassan, Vanessa Yu, Anthony Lembo, Judy Nee, Johanna Iturrino

3:30 pm | AGA Research Symposium
Funderburg Symposium - Gastric Tumorigenesis Models: Organoids and Mice
Moderator: John Kao

4:44 pm | AGA Research Symposium | AGA Funderburg Symposium
Gastric Tumorigenesis Models: Organoids and Mice
Live Q&A: Diane Bimczok, John Y. Kao, Anne Muller, Jose Saenz, Daniel E. Stange

5:30 pm | AGA Research Forum
Exploring Issues of Diversity & Disparity in Gastroenterology
Moderator: John Carethers

5:30 pm | AGA Translational Symposium
AGA-CSG: Best of DDW in Chinese
Moderator Introduction: John Y. Kao

5:32 pm | AGA Translational Symposium
IBD and microbiota related to GI disorders
John Y. Kao

5:33 pm | AGA Plenary | AGA Basic Science Plenary
Discrete LGR4 expressing BDNF neurons in the paraventricular hypothalamus controls thermogenesis in brown adipose tissues: Impairment by high fat feeding
Ji-Yao Li, Xiaoyin Wu, Gintautas Grabauskas, Chung Owyang

5:54 pm | AGA Clinical Symposium
How do I integrate behavior and dietary therapy in irritable bowel syndrome?
William D. Chey

6:00 pm | AGA Research Forum
Crohn’s disease, anxiety and depression, and baseline C-reactive protein level predict risk for incident irritable bowel syndrome–like symptoms in quiescent inflammatory bowel disease
Mehwish Ahmed, Krishna Rao, Shrinivas Bishu, William D. Chey, Peter D.R. Higgins, Allen Lee

6:45 pm | AGA Plenary
AGA Basic Science Plenary
Live Q&A: Kathleen DelGiorno, Mark Donowitz, Yuan Fang, Klaus H. Kaestner, Ji-Yao Li, Simon M. Mwangi, Michael Pack, Chi Chun Wong

Saturday, May 22

10:02 am | AGA Clinical Symposium | Barrett’s Esophagus: What’s New From Diagnosis Through Treatment
Presentation of Research Mentor Award: John M. Inadomi, MD, AGAF
Presenter: Joel H. Rubenstein

10:06 am | AGA Clinical Symposium | Barrett’s Esophagus: What’s New From Diagnosis Through Treatment
Who is at risk and should we screen?
Joel H. Rubenstein

10:16 am | AGA Research Forum
Mast-cell activation leading to colonic barrier dysfunction following high-FODMAP diet is mediated via lipopolysaccharide
Prashant Singh, Gintautas Grabauskas, Shi-Yi Zhou, Yawen Zhang, Chung Owyang

10:30 am | AASLD Research Forum
Viscoelastic testing prior to procedures reduces blood product utilization without increasing bleeding risk in cirrhosis: A systematic review and meta-analysis
Abhishek Shenoy, Jeremy Louissaint, Carol Shannon, Elliot B. Tapper, Anna Lok

10:30 am | AGA Research Forum
B cell clonotypes underlying Helicobacter-induced gastric pre-neoplasia in mice
Mohamad El-Zaatari, Min Zhang, Helmut Grasberger, Marilia Cascalho, John Y. Kao

10:38 am | AGA Research Forum
Inflammatory bowel disease risk variants are associated with an increased risk of skin cancer
Kelly Cushing, Xiaomeng Du, Yanhua Chen, LC Stetson, Annapurna Kuppa, Vincent L. Chen, J Michelle Kahlenberg, Johann Gudjonsson, Peter D.R. Higgins, Elizabeth Speliotes

10:44 am | AGA Plenary | Liver & Biliary Distinguished Abstract Plenary
GALAD demonstrates high sensitivity for early-stage detection of hepatocellular carcinoma in a cohort of patients with cirrhosis
Amit G. Singal, Nabihah Tayob, Austin J Fobar, Qingchun Jin, Cristian Saenz de Viteri, Jorge A. Marrero, Neehar Dilip Parikh

11:00 am | AGA Research Forum
CB6, a novel gut-selective BCL-2 inhibitor, attenuates intestinal fibrosis in myofibroblast cell models and the mouse S. typhimurium model of intestinal fibrosis
Yongjia Feng, Laura Johnson, Meng Zhang, Stephen Collins, Shaomeng Wang, Peter D.R. Higgins

11:10 am | AGA Clinical Symposium
Barrett’s Esophagus: What’s New From Diagnosis Through Treatment
Live Q&A: Douglas A. Corley, Rebecca C. Fitzgerald, Joel H. Rubenstein, Nicholas J. Shaheen

1:00 pm | AGA State-of-the-Art Lecture
AGA Morton I. Grossman Distinguished Lectureship
Welcome and Introduction of Lectureship and Lecturer: Linda C. Samuelson

1:10 pm | AGA State-of-the-Art Lecture | AGA Morton I. Grossman Distinguished Lectureship
Communicate!! The Essential Nature of Crosstalk in Development, Disease and Science
Deborah L. Gumucio

1:16 pm | AGA Research Forum
Functional dyspepsia and gastroparesis are interchangeable syndromes with common clinical and pathological features
Pankaj J. Pasricha, Madhusudan Grover, Katherine Parker Yates, Thomas Abell, Cheryl Bernard, Kenneth L. Koch, Richard W. McCallum, Irene Sarosiek, Braden Kuo, Robert S Bulat, Jiande Chen, Robert J. Shulman, Linda A Lee, James Tonascia, Laura A Miriel, Frank A. Hamilton, Henry P. Parkman

1:17 pm | ASGE Plenary | ASGE Presidential Plenary II
Panel Discussion: Impact of health care reform on the practice of gastroenterology
John I. Allen, Michael Chernew

1:20 pm | AASLD Plenary | AASLD Clinical Science Plenary
The association of sustained virologic response on treatment outcomes in patients with hepatocellular carcinoma with hepatitis C
Neehar D. Parikh, Neil Mehta, Maarouf Hoteit, Ju Dong Yang, Binu V. John, Andrew M. Moon, Reena Salgia, Anjana A. Pillai, Ihab Kassab, Naba Saeed, Emil Thyssen, Piyush Nithani, Jeffrey Mckinney, Wesley Chan, Claire Durkin, Matthew Connor, Manaf Alsudaney, Brenda Durand, Nicholas N. Nissen, Hannah P. Kim, Raghavendra Paknikar, Nicole E. Rich, Matthew Schipper, Amit G. Singal

2:00 pm | AASLD Plenary | AASLD Clinical Science Plenary
Panel Discussion: Joseph Ahn, Bashar Aqel, Jasmohan Bajaj, Waihong Chung, Neehar D. Parikh, Andy Tien

2:10 pm | AGA State-of-the-Art Lecture
AGA Morton I. Grossman Distinguished Lectureship
Live Q&A: Deborah L. Gumucio, Linda C. Samuelson

2:15 pm | AASLD Research Forum
Alpha-1 antitrypsin Pi*MZ genotype associates with more rapid decompensation and decreased transplant-free survival among patients with compensated cirrhosis
Daniel A. Burkholder, Isabel J. Moran, Jacob V. DiBattista, Elizabeth Speliotes, Vincent L. Chen

3:30 pm | AGA Research Forum
Inflammation and GI Cancers
Moderator Introduction: John Y. Kao

3:32 pm | AGA Clinical Symposium
Genetics of obesity – The hammer or the nail?
Elizabeth Speliotes

3:48 pm | AGA Translational Symposium
Association of deleterious DUOX2 variants with a preclinical hallmark of disturbed microbiota-immune homeostasis and risk of inflammatory bowel disease
Helmut Grasberger, Andrew Magis, Elisa Sheng, Matthew P. Conomos, Min Zhang, Lea Sophia Garzotto, Guoqing Hou, Shrinivas Bishu, Hiroko Nagao-Kitamoto, Mohamad El-Zaatari, Sho Kitamoto, Nobuhiko Kamada, Ryan Stidham, Yasutada Akiba, Jonathan D. Kaunitz, Yael Haberman, Subra Kugathasan, Lee A. Denson, Gilbert S. Omenn, John Y. Kao

4:00 pm | AGA Research Forum
Endoscopy and systematic biopsy of patients with chronic gastrointestinal symptoms leads to high discovery rate of patients who meet histologic criteria for eosinophilic gastritis and/or eosinophilic duodenitis
Nicholas J. Talley, Amol P. Kamboj, William D. Chey, Henrik S Rasmussen, Brian E. Lacy, Ikuo Hirano, Mirna Chehade, Nirmala Gonsalves, Kathryn A. Peterson, Anthony Lembo, Colleen Maclin Schmitt, Marc E. Rothenberg, Robert M Genta, Maria A Pletneva, Kevin Turner, Malika Pasha, Evan S. Dellon, William J. Sandborn

5:30 pm | AGA Clinical Symposium
Gender Disparities in GI: Progress and Challenges
Moderator Introduction: Megan A. Adams

5:30 pm | AGA Research Symposium
Kiron and Kamala Das Symposium: Cell Death in the Intestinal Epithelium
Moderator Introduction: Yatrik M. Shah

5:33 pm | AGA Clinical Symposium
Promotions and pay structure
John I. Allen

5:50 pm | AGA Research Symposium | Kiron and Kamala Das Symposium: Cell Death in the Intestinal Epithelium
Ferroptosis in the intestinal epithelium
Yatrik M. Shah

6:02 pm | AGA Clinical Symposium | Identifying and Managing Issues of Pancreatic Insufficiency
Nutritional evaluation and dietary management
Amanda Lynett

6:14 pm | AGA Research Forum
Efficacy of high-dose dual therapy and bismuth quadruple therapy in first-line and rescue Helicobacter pylori eradication – a final report of multi-center, randomized control study
Chien-Chih Tung, Chi-Tan Hu, Chun-Jung Lin, I-Nan Kuo, Bor-Ru Lin, Hong-Long Wang, Jin-De Chen, Mu-Liang Cheng, Chia-Tung Shun, John Y. Kao, Jyh-Chin Yang

6:17 | AGA Clinical Symposium | Identifying and Managing Issues of Pancreatic Insufficiency
Charting a pathway of success in enzyme replacement
Matthew J. DiMagno

6:31 | ASGE Clinical Symposium
Putting it all together: How to set up your bariatric program
Allison R. Schulman

Sunday, May 23

10:00 am | AGA Clinical Symposium
Bringing QI to GI: Translating Quality Measures to Practice
Moderator Introduction: Megan A. Adams

10:00 am | AGA Research Forum
Novel Approaches to Studying Physiology of the Esophagus
Moderator: Joan Chen

10:00 am | AGA Research Forum
Microbiome and Host Response in IBD
Moderator Introduction: Nobuhiko Kamada

10:31 am | AGA Clinical Symposium
The forgotten indication: National estimates of proton pump inhibitor prescribing for prevention of upper gastrointestinal bleeding in the United States from 2005–2016
Jacob E. Kurlander, John N. Mafi, Elliot B. Tapper, Geoffrey Barnes, Caroline R. Richardson, Joel H. Rubenstein, Sameer Dev Saini, Patrick D Meek

10:45 am | AGA Clinical Symposium
Implementing quality measures in integrated healthcare delivery systems: Endoscopic overuse
Sameer D. Saini

11:01 am | AGA Research Symposium
The risks and benefits of JAK inhibitors in acute severe UC
Peter D. Higgins

1:00 pm - ASGE Clinical Symposium
ERCP 101
Moderator: Grace Elta

1:02 pm | AASLD Clinical Symposium | Management of HBV in the Young Population
Management of the “immune tolerant” patient: How to evaluate, to treat or not to treat?
Anna S. Lok

1:02 pm | AGA Clinical Symposium
Artificial intelligence in IBD imaging and endoscopy
Ryan Stidham

1:02 pm | AGA Research Forum
Ameliorating effects and mechanisms of auricular vagal nerve stimulation in a rodent model of functional dyspepsia
Liwei Hou, Juan Han, Wei Wei, Jiande Chen, Jiliang Fang, Jinling Zhang, Junying Wang, Peijing Rong

1:02 pm | AGA Research Symposium
Metabolites regulating gastrointestinal neoplasms
Costas A. Lyssiotis

1:30 pm | AGA Plenary | AGA Clinical Science Plenary
A multicomponent intervention reduces proton pump inhibitor use without evidence of harm: A quasi-experimental study of over 4 million US veterans
Jacob Eli Kurlander, Sameer Dev Saini, Loren Laine, Hyungjin Myra Kim, Christopher B. Roberts, Michelle Shank, Yu-Xiao Yang

2:07 pm | AASLD Clinical Symposium
Liver transplantation for DILI: Predicting the need and managing the patient
Robert J. Fontana

2:12 pm | AGA Plenary
AGA Clinical Science Plenary
Live Q&A: Emilie C. Breekveldt, Sine Buhl, Li-Chun Chang, John M. Inadomi, Fasiha Kanwal, Jacob E. Kurlander, Benjamin H. Mullish

2:17 pm | AGA Research Symposum
Metabolites and Bioactive Lipids in GI Disease
LIVE Q&A: Matthew A. Ciorba, Sean P. Colgan, Ravinder K. Gill, Costas A. Lyssiotis, Shipra Vaishnava

3:25 pm | DDW Clinical Symposium | Best of DDW 2021
Best of AASLD
Grace Su

3:30 pm | ASGE Clinical Symposium
ERCP at the Cutting Edge
Welcome: Michelle A. Anderson

3:30 pm | AGA Research Forum
Advances in the Pathogenesis, Diagnosis and Treatment of Gastroesophageal Reflux Disease
Moderator Introduction: Joan W. Chen

3:30 pm | AGA Plenary
Cellular & Molecular Gastroenterology (CMG) Section Distinguished Abstract Plenary
Moderator: Linda Samuelson

3:30 pm | AGA Plenary
Immunology, Microbiology & Inflammatory Bowel Diseases (IMIBD) Section Distinguished Abstract Plenary
Moderator Introduction: Peter D. Higgins

4:11 pm | AGA Plenary | AGA Immunology, Microbiology & Inflammatory Bowel Diseases Section | Distinguished Abstract Plenary
Clinical coordination and intense proactive monitoring to improve utilization of resources and reduce expenditures in high-risk IBD patients (CAPTURE IBD): A randomized, controlled quality improvement trial
Jeffrey Berinstein, Gillian Greenberg, Shirley Cohen-Mekelburg, Peter D.R. Higgins

4:27 pm | DDW Symposium | DDW Diversity Symposium: Unique Patient Populations with GI Diseases Experiencing Barriers to Care
Socioeconomic barriers to gastroenterological care
John M. Carethers

4:36 pm | AGA Plenary
AGA Cellular & Molecular Gastroenterology Section Distinguished Abstract Plenary
Live Q&A: Kathleen DelGiorno, Yuki Hayata, Izumi Kaji, Emilia J. Orzechowska, Saeed Soleymanjahi, Linda C. Samuelson, Xiaohong Wang

4:47 pm | AGA Plenary | AGA Immunology, Microbiology & Inflammatory Bowel Diseases Section | Distinguished Abstract Plenary
Live Q&A: Jeffrey Berinstein, Mark J. Daly, Peter D. Higgins, Yuval Itan, Sun-Ho Lee, James D. Lewis, Florence-Damilola Odufalu, Fernando Velayos

5:00 pm | DDW Symposium
Diversity Symposium Networking Session
Live Q&A: John Carethers, Aline Charabaty, William Dewitt, Pilar Ortega, Matthew Walsh, Julius Wilder

5:30 pm | AGA Research Forum
Biologic and Disease Monitoring in IBD
Moderator: Shirley Cohen-Mekelburg

6:28 pm | AGA Plenary | Clinical Practice Distinguished Abstract Plenary
Validation of tools for predicting incident adenocarcinoma of the esophagus or esophagogastric junction
Joel H. Rubenstein, Trivellore Raghunathan, Cecilia Doan, Jennifer L Schneider, Wei K. Zhao, Valbona Metko, Kimberly Nofz, Maryam Khodadost, Douglas A. Corley

Poster Sessions

Friday, May 21

Fr080
Prevalence of bowel disorders in multiple sclerosis and Parkinson’s disease: Results from a nationwide survey of nearly 90,000 Americans
Christopher Velasquez Almario, William D. Chey, Carolyn S. Higgins, Brennan Spiegel

Fr085
Estimating the system-level costs of for-profit journals on academic gastroenterology research
Emily Harding-Theobald, Bharat Maraj

Fr105 | AGA Poster of Distinction
Continuity of care for patients with chronic gastrointestinal disease: A latent class analysis of patients with high-intensity specialty care needs
Shirley Cohen-Mekelburg, Liberty Greene, Akbar K. Waljee, Timothy Hofer, Sameer Dev Saini, Donna Zulman

Fr384
Doylestown Plus algorithm as a novel biomarker to detect hepatocellular carcinoma in patients with cirrhosis
Amit G. Singal, Nabihah Tayob, Anand Mehta, Austin J. Fobar, Qingchun Jin, Cristian Saenz de Viteri, Jorge A. Marrero, Neehar D. Parikh

Fr393
Stage migration after transarterial chemoembolization as a predictor of survival in patients with hepatocellular carcinoma
Ihab Kassab, Sagar Joshi, Amit G. Singal, Vincent L. Chen, Neehar D. Parikh

Fr429 | AGA Poster of Distinction
TLR4 signal transduction pathway mediates upregulation of 2-pore domain potassium TRESK channel and is responsible for high-fat diet-induced vagal afferent dysfunction
Shi-Yi Zhou, Xiaoyin Wu, Ji-Yao Li, Gintautas Grabauskas, Merritt Gillilland, Chung Owyang

Fr438
Prevalence and burden of illness of Rome IV chronic idiopathic constipation, opioid-induced constipation, and opioid-exacerbated constipation in the U.S.
Christopher Velasquez Almario, William D. Chey, Carolyn S. Higgins, Brennan Spiegel

Fr440
Women’s health factors are not associated with altered bowel habits: Results of a national health and nutrition examination survey
Sophie L Brigstocke, Judy Nee, Sarah Ballou, Shuji Mitsuhashi, Vikram Rangan, Prashant Singh, Rafla Hassan, Carsten Langholm, Johanna Iturrino

Fr445
Do chronically constipated patients with an evacuation disorder have impaired constipation-specific quality of life?
Borko Nojkov, Jason R Baker, Gabrielle Ezell, Moira Armstrong, Lydia Watts, William D. Chey

Fr546
Interventions to increase vaccinations rates with inflammatory bowel disease and rheumatoid arthritis: a systematic review and meta-analysis
Jalpa Patel, Dina Fakhouri, Mohamed Noureldin, Iris Kovar-Gough, Francis A Farraye, Bradley Warren, Akbar K. Waljee, Marc Steven Piper

Fr553
Patient perceptions on transition from clinic-based infusions to home-based infusions for inflammatory bowel disease patients during the COVID-19 pandemic: a qualitative quality improvement study
Janson Jacob, Daniel Aintabi, Melissa DeJonckheere, John I. Allen, David Irani, A. Mark Fendrick, Akbar K. Waljee, Peter D.R. Higgins, Jeffrey Berinstein

Fr562
Detection of pks+ Escherichia coli associates with the presence of tubular adenomas and left-side colonic polyps in healthy patients undergoing screening colonoscopy
Victoria L Campodónico, Myron Jackson, Madison Mcmann, Emma Spence, Celina Santiago, Carisse Lansiquot, Samara Rifkin, Julia L Drewes, Courtney Stevens, Joell J Gills, Amy Lynn Schiller, Pamela Schearer, Stacy Gerhart, David M Cromwell, Marshall Bedine, Eduardo Gonzalez-Velez, Hazel Marie Galon Veloso, Gerard Mullin, David Kafonek, Louis La Luna, Linda Hylind, Francis Giardiello, Cynthia L Sears

Fr565
Initial and repeat colonic microbial biofilm detection in a healthy screening colonoscopy cohort
Julia L Drewes, Madison Mcmann, Courtney Stevens, Samara Rifkin, Emma Spence, Celina Santiago, Joell J Gills, Carisse Lansiquot, Amy Lynn Schiller, Pamela Schearer, Stacy Gerhart, Karin Donato, David M Cromwell, Marshall Bedine, Eduardo Gonzalez-Velez, Hazel Marie Galon Veloso, Gerard Mullin, David Kafonek, Louis La Luna, Linda Hylind, Francis Giardiello, Cynthia L Sears

Fr568
Fusobacterium nucleatum infection is facilitated in colon cancer cells expressing gel-forming mucins
Koki Takeda, Minoru Koi, Jovan Pierre-Charles, Chan Choi, Eric Martens, John M. Carethers

Saturday, May 22

Sa058
Rapid onset of time to first spontaneous bowel movement (SBM) and predictable efficacy of oral once daily naloxegol: Pooled analysis of two global randomized controlled trials
William D. Chey, Carol B. Rockett, Enoch Bortey, June Almenoff

Sa059
Naloxegol given orally once daily achieved rapid and sustained improvement of opioid-induced constipation (OIC) symptoms: A pooled analysis of two global randomized placebo-controlled trials
William D. Chey, Carol B. Rockett, Enoch Bortey, June Almenoff

Sa121
Polymorphic Δ27bpMSH3, enriched in colorectal cancer and ulcerative colitis, relies on the NF-κB-associated protein NEMO for stability after MSH2 dissociation by IL-6
Stephanie Tseng-Rogenski, John M. Carethers

Sa250 | AGA Poster of Distinction
The suitability of the current EUCAST H pylori amoxicillin resistance breakpoints in predicting high-dose amoxicillin-PPI dual salvage therapeutic efficacy and in assessing amoxicillin resistance rates in the U.S.
Ashley Cawthon, Chien-Chih Tung, Min Zhang, Mohamad El-Zaatari, Helmut Grasberger, Jyh-Chin Yang, John Y. Kao

Sa343
Comparison of scoring systems for diagnosing hepatic steatosis in the absence of imaging using real-world health data
Jacob V. DiBattista, Daniel A. Burkholder, Anna Lok, Vincent L. Chen

Sa357
Disease knowledge, health-related quality of life and lifestyle behavior change in patients with non-alcoholic fatty liver disease
Lisa Glass, Haila Asefa, Michael Volk, Anna Lok, Monica A. Tincopa

Sa387
Dietary monosodium glutamate (MSG) acts on TAS1R1/TAS1R3 expressing gastric tuft cells to stimulate ATP release and induce visceral hypersensitivity
Yawen Zhang, Gintautas Grabauskas, Xiaoyin Wu, Jun Gao, Chung Owyang

Sa393 | AGA Poster of Distinction
Gastroparesis patients with greater short-term symptom improvements after G-POEM demonstrate less severe pyloric dysfunction on EndoFLIP testing
Lydia Watts, Moira Armstrong, Gabrielle Ezell, Jason R Baker, Nicole Bowers, Ryan Law, William L. Hasler

Sa399
Wireless motility capsule identifies a distinct phenotype of gastric dysmotility with an associated differential response to drug therapy
Trisha Satya Pasricha, John Russell Semler, Allen Lee, Baha Moshiree, William L. Hasler, Braden Kuo

Sa403
Coefficients of variation of pyloric diameter and distensibility and reproducibility of EndoFLIP testing in gastroparesis patients undergoing pyloric therapy
Moira Armstrong, Lydia Watts, Gabrielle Ezell, Jason R Baker, Nicole Bowers, Ryan Law, William L. Hasler

Sa409
Terminology impacts simulated defecation responses during anorectal manometry: Analysis of the London classification for disorders of anorectal function
Jason Baker, Mackenzie Jarvis, Elyse Thakur, William D. Chey, Rafat Rizk, Darren M. Brenner, Eric D. Shah, Baha Moshiree

Sa423
Quantifying healthcare utilization and delay in treatment of gastric stenosis following sleeve gastrectomy
Jiwon V. Park, Maxwell T. Sievers, Paris D. Rollins, Alyssa M. Hardin, Hootan M. Omidvar, Laura Mazer, Allison R. Schulman

Sa542
Initial results from a multicenter prospective registry evaluating pouch-related outcomes
Edward Lee Barnes, Parakkal Deepak, Poonam Beniwal-Patel, Laura Harrell Raffals, Maia Kayal, Marla Dubinsky, Shannon Chang, Peter D.R. Higgins, Jennifer I Barr, Joseph Galanko, Raymond K. Cross, Millie Dascomb Long, Hans H. Herfarth

Sa593
Fermentation product propionic acid produced by specific gut bacteria induces barrier dysfunction and subclinical mucosa inflammation
Yawen Zhang, Jun Gao, Shi-Yi Zhou, Binrui Chen, Ning Dai, Xin Wang, Chung Owyang

Sa602 | AGA Poster of Distinction
The gut microbiota utilizes different signaling mechanisms to stimulate DUOX2 expression in the colon of IBS patients
Jun Gao, Gintautas Grabauskas, Chung Owyang

Sa625
Closed-loop intestinal electrical stimulation synchronized with intrinsic intestinal slow wave ameliorates glucagon-induced hyperglycemia in rats via enhanced release of GLP-1
Shiying Li, Hongbing Zhu, Philippe Fady Moussalli, Jiande Chen

Sa628
M3 cholinergic pathway underlies the hypoglycemic effect of intestinal electrical stimulation via enhanced release of incretin hormones in the postprandial state
Yan Dong, Yiling Zhang, Shiying Li, Jiande Chen

Sunday, May 23

Su007 | ASGE Poster of Distinction
Variability in endoscopic assessment of Nissen fundoplication wrap integrity and hiatus herniation: A multi-center study
Erin J. Song, Rena H. Yadlapati, Joan W. Chen, Alice Parish, Matthew J. Whitson, Karthik Ravi, Amit Patel, Dustin Carlson, Abraham Khan, Donna Niedzwiecki, David A. Leiman

Su085
Prevalence and burden of illness of Rome IV irritable bowel syndrome in the U.S.
Christopher Velasquez Almario, William D. Chey, Carolyn S. Higgins, Brennan Spiegel

Su092
Who reports post-prandial diarrhea? Analysis of a cohort of patients with chronic diarrhea
Rafla Hassan, Prashant Singh, Sarah Ballou, Vanessa Yu, Vikram Rangan, Judy Nee, Johanna Iturrino, Anthony Lembo

Su140
Chronic psychological stress alters gene expression in rat colon epithelial cells associated with barrier dysfunction, inflammation, and chromatin remodeling
John W. Wiley, Gerald A. Higgins, Shuangsong Hong

Su343 | AASLD Poster of Distinction
Ammonia testing is overused and leads to excess lactulose use: A prospective, blinded assessment of ammonia test utility among front-line clinicians
Juan J. Gonzalez, Elliot B. Tapper

Su364
Pill or procedure? Understanding patient preferences regarding beta-blockers as an alternative to endoscopic variceal screening during the COVID-19 pandemic
Zheng Che, Jeremy Louissaint, Ihab Kassab, Elliot B. Tapper

Su474
Healthcare utilization among inflammatory bowel disease patients receiving opioids: A systematic review and meta-analysis
Jessica L. Sheehan, Janson Jacob, Calen Andrew Steiner, Sameer K Berry, Carol Shannon, Shirley Cohen-Mekelburg, Peter D.R. Higgins, Jeffrey Berinstein

Su485
Cannabis users with inflammatory bowel disease in clinical remission have increased levels of subclinical inflammation
Madeline Bertha, Diego Jimenez Lara, Jami Kinnucan, Stephen B. Hanauer

Su554 | AGA Poster of Distinction
Prevalence of sucrase-isomaltase deficiency in adults with irritable bowel syndrome and diarrhea and functional diarrhea: An interim analysis from a prospective US trial
Samuel Chey, William D. Chey, Shanti L. Eswaran

Su562
Does mucosal Akkermansia abundance predict omega fatty acids and PGE2 production after dietary intervention?
Samara Rifkin, Ananda Sen, D. Kim Turgeon, Mack T. Ruffin, Dean E Brenner, Patrick D Schloss, Zora Djuric

Su576
Are all FODMAPs created equal? A blinded, randomized reintroduction trial to determine which FODMAPs drive clinical response in IBS patients
Shanti L. Eswaran, Prashant Singh, Samara Rifkin, William D. Chey

Su577
Does the gut microbiome explain the clinical benefits of green kiwifruit, psyllium, or prunes in US patients with chronic constipation?
Samuel Chey, Christine Marie Bassis, Vincent Bensan Young, William D. Chey, Shanti L. Eswaran