Publications

Chenchen He, PhD (2019-2021)

  • Kimutai B, He CC, Roberts A, Jones ML, Bao X, Jiang J, Yang Z, Rodgers MT, and Chow CS. Amino Acid-Linked Platinum (II) Compounds: Non-Canonical Nucleoside Preferences and Influence on Glycosidic Bond Stabilities. (2019). J. Biol. Inorg. Chem. 24:985-997. PMC3139185. 
  • Devereaux ZJ, Roy HA, He CC, Zhu Y, Cunningham NA, Hamlow LA, Berden G, Oomens J, and Rodgers MT. Influence of 2’-Fluoro Modification on Glycosidic Bond Stabilities and Gas-Phase Ion Structures of Protonated Pyrimidine Necleosides. (2019). J. Fluor. Chem. 210:10-22. 
  • Hamlow LA, He CC, Devereaux ZH, Roy HA, Cunningham NA, Soley EO, Berden G, Oomens J, and Rodgers MT. Gas-Phase Structures of Protonated Arabino Nucleosides. (2019). Int. J. Mass Spectrom. 438:124-134.
  • Devereaux ZJ, He CC, Zhu Y, Roy HA, Cunningham NA, Hamlow LA, Berden G, Oomens J, and Rodgers MT. Structures and Relative Glyosidic Bond Stabilities of Protonated 2’-Fluoro Substituted Purine Nucleosides. (2019). J. Am. Soc. Mass Spectrom. 30:1521-1536. 
  • He CC, Hamlow LA, Zhu Y, Nei YW, Fan L, McNary CP, Maitre P, Steinmetz V, Schindler B, Compagnon I, Armentrout PB, and Rodgers MT. Structural and Energetic Effects of 02’-Ribose Methylation of Protonated Pyrimidine Nucleosides. (2019). J. Am. Soc. Mass Spectrom. 30:2318-2334.
  • Afshinnia F, Rajendiran TM, He CC, Byun J, Montemayor D, Darshi M, Turnova J, Kim J, Limonte CP, Miller RG, Costacou T, Orchard TJ, Ahluwalia T, Rossing P, Snell-Bergeon JK, deBoer IH, Nataragjan L, Michailidis G, Sharma K, and Pennathur S. Lipidomic Predictors of Rapid Decline of Kidney Function in Patients with Type 1 Diabetes. (2021). Submitted.
  • Afshinnia F, Rajendiran TM, He CC, Byun J, Montemayor D, Darshi M, Turnova J, Kim J, Limonte CP, Miller RG, Costacou T, Orchard TJ, Ahluwalia T, Rossing P, Snell-Bergeon JK, deBoer IH, Nataragjan L, Michailidis G, Sharma K, and Pennathur S. Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients with Type 1 Diabetes. (2021). Diabetes Care. Under revision.
  • Baek J, He CC, Afshinnia F, Michailidis G, and Pennathur S. Approaches to Dissect Dysregulated Lipid Metabolism in Kidney Disease. (2021). Nat. Rev. Nephrol. Submitted.

Allison Kowalsky, PhD (2019-2021)

  • Cho CS, Kowalsky AH, Namkoong S, Park SR, Wu S, Kim B, James A, Gu B, Semple IA, Tohamy M, Solanki S, Cho US, Greenson JK, Shah YM, Kim M, and Lee JH. Concurrent Activation of Growth Factor and Nutrient Arms of mTORC1 Induces Oxidative Liver Injury. (2019). Cell Discov. 5:60.
  • Kim M, Sujkowaski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, et al. Sestrins Are Evolutionarily Conserved Mediators of Exercise benefits. (2020). Nat Comm. 11:190.
  • Kowalsky AH, Namkoong S, Park HW, Kazyken D, Fingar D, and Lee JH. Sestrin2 Activates Akt Through GATOR2-mTORC2. (2020). J Biol Chem. 14:295(7):1769-1780.
  • Cho CS, Kowalsky AH, and Lee JH. Pathological Consequences of Hepatic mTORC1 Dysregulation. (2020). Genes. 11(8):E896.
  • Kim M, Kowalsky AH, and Lee JH. Sestrins in Physiological Stress Responses. (2021). Ann Rev Physiology. 83:381-403.

Phillip Webster, PhD (2019-2021)

  • Flesher C, Baker N, Barboza C, Polsinelli D, Webster P, Varban O, Lemeng C, and O’Rourke R. A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolism Crosstalk. (2019). Journal of Visualized Experiments.

Irina Zhang, PhD (2020-2021)

  • Zhang IX, Ren J, Vadrevu S, Raghavan M, and Satin LS. ER Stress Increases Store-Operated Ca2+ Entry (SOCE) and Augments Basal Insulin Secretion in Pancreatic B Cells. J Biol. Chem. 295(17):5685-5700.
  • Zhang IX, Raghavan M, and Satin LS. The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells. (2020). Endocrinology. 161.

 

See below for publications by our former trainees.

Rebecca Schill, PhD (2018-2019)

  • Bagchi DP, Corsa CA, Hardij JM, Hiroyuki, Learman B, Lewis KT, Schill RL, Romanelli SM, and MacDougald OA. Wntless Regulates Lipogenic Gene Expression in Adipocytes and Protects Against Diet-Induced Metabolic Dysfunction. (2020). Molecular Metabolism. PMC7264081.
  • Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D. Modification of HDL by Reactive Aldehydes Alters Select Cardio-Protective Functions of HDL in Macrophages. (2019) F.E.B.S J. 2019 Aug 6.
  • Chen N, Schill RL, O’Donnell M, Xu K, MacDougald OA, Koenig RJ, Xu B. Novel Role of the Transcription Factor Nkx1-2 in the Regulation of Adipogenesis. (2019).
  • Li Z, Hardij J, Evers SS, Hutch CR, Choi SM, Shao Y, Learman BS, Lewis KT, Schill RL, Mori H, Corsa CAS, Bagchi DP, Romanelli SM, Kim K, Griffin C, Seeley RJ, Singer K, Sandoval DA, Rosen CJ, MacDougald OA. G-CSF Partially Mediates Effects of Sleeve Gastrectomy on the Bone Marrow Niche. (2019). JCI. 6: 130. PMID: 31063988. 

Sarah Elzinga, PhD (2017-2019)

  • Guo K., Eid S.A., Elzinga S.*, Pacut C., Feldman E.L., Hur J. Genome-Wide Profiling of DNA Methylation and Gene Expression Identifies Candidate Genes for Human Diabetic Neuropathy. Clinical Epigenetics (2020): Accepted for publication. *co-first authorship
  • Zak A., Siwinska N., Elzinga S., et al. Effects of Equine Metabolic Syndrome (EMS) on Inflammation and Acute-Phase Markers in Horses. Domestic Animal Endocrinology (2020): 106448.
  • Zak A., Siwinska N., Elzinga S., et al. Effects of Advanced Age and Pituitary Pars Intermedia Dysfunction on Components of the Acute Phase Reaction in Horses. Domestic Animal Endocrinology (2020): 106476.
  • Elzinga SE., et al. Effects of Docosahexaenoic Acid (DHA)-Rich Microalgae Supplementation on Metabolic and Inflammatory Parameters in Horses with Equine Metabolic Syndrome. Journal of Equine Veterinary Science (2019): 102811. 
  • Guo K, Elzinga S*, Eid S, et al. Genome-Wide DNA Methylation Profiling of Human Diabetic Peripheral Neuropathy in Subjects with Type 2 Diabetes Mellitus. Epigenetics 14 (2019):1-14. *co-first authorship.
  • Elzinga SE*, et al. Toll-Like Receptors and Inflammation in Metabolic Neuropathy; A Role in Early Versus Late Disease? Experimental Neurology 320 (2019):112967. *co-first authorship.
  • Kim, B., Elzinga, S. E.*, et al. The Effects of Insulin and Insulin-Like Growth Factor I on Amyloid Precursor Protein Phosphorylation in In Vitro and In Vivo Models of Alzheimer's Disease. Neurobiology of Disease 132 (2019):104541. *co-first authorship.
  • Loos, C. M. M., Dorsch S. C., Elzinga S., et al. A High Protein Meal Affects Plasma Insulin Concentrations and Amino Acid Metabolism in Horses with Equine Metabolic Syndrome. The Veterinary Journal 251 (2019): 105341.

Chelsea Hutch, PhD (2017-2018)

  • Hutch CR, Sandoval DA. 2017. Physiological and Molecular Responses to Bariatric Surgery: Markers or Mechanisms Underlying T2DM Resolution? Ann NY Acad Sci. 1391(1):5-9.
  • Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D’Alessio DA, Seeley RJ, Sandoval DA. 2017. The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice. Cell Metab. 25(4):927-934.
  • Hutch CR, Sandoval D. 2017. The Role of GLP-1 in the Metabolic Success of Bariatric Surgery. Endocrinology. 158(12):4139-4151.
  • Hutch CR, Stalmak D, Kanakadurga S, Sandoval D. 2018. Diet-Dependent Sex Differences in the Response

Bailey Peck, PhD (2017-2018)

  • Peck BCE, Seeley RJ. 2018. How Does “Metabolic Surgery’ Work its Magic? New Evidence for Gut Microbiota. Endocrinology & Diabetes and Obesity. 13:1-6.

Jessica Adams, PhD (2016-2018)

  • Pan W, Adams JM, Allison MB, Patterson C, Flak JN, Jones J, Stohbehn G, Trevaskis J, Rhodes CH, Olson, DP, Myers MG Jr. 2018. Essential Role for Hypothalamic Calcitonin Receptor – Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology. 159(4): 1860-1872.
  • Adams JM, Pei H, Sandoval DA, Seeley RJ, Chang RB, Liberles SD, Olson DP. 2018 Liraglutide Modulates Appetite and Body Weight Via GLP-1R-Expressing Glutamatergic Neurons. Diabetes. PMC29776968.
  • Adams JM, Olson DP. 2017. Investigating the Anorectic Mechanisms of GLP-1R Agonists. Abstract selected for oral presentation, Brehm Center for Diabetes Research Summer Diabetes Symposium, Ann Arbor, MI. ABSTRACT

Callie Corsa, PhD (2015-2017)

  • Corsa CA, Mori H, Barnes TM, Koza RA, MacDougald OA. 2017. Investigating the Role of SFRP5 and Wnt Signaling in Adipocyte Metabolism. Cold Spring Harbor Laboratories: Mechanisms of Metabolic Signaling, Cold Spring Harbor, NY, May. ABSTRACT
  • Corsa CA, Mori H, Barnes TM, Koza RA, MacDougald OA. 2017. Investigating the Role of SFRP5 and Wnt Signaling in Adipocyte Metabolism. University of Michigan Brehm Summer Symposium, Ann Arbor, MI, August. ABSTRACT

Lisa Guth, PhD (2015-2017)

  • Van Pelt DW, Guth LM, Horowitz JF. 2017. Aerobic Exercise Elevates Markers of Angiogenesis and Macrophage IL-6 Gene Expression in the Subcutaneous Adipose Tissue of Overweight-to-Obese Adults. J Appl Physiol 123:1150-1159.
  • Van Pelt DW, Guth LM, Wang AY, Horowitz JF. 2017. Factors Regulating Subcutaneous Adipose Tissue Storage, Fibrosis, and Inflammation May Underlie Fatty Acid Mobilization in Insulin-Sensitive Obese Adults. Am J Physiol Endocrinol Metab. 313:E429-E439.
  • Guth LM, Van Pelt DW, Horowitz JF. 2016. Basal Systemic Fatty Acid Mobilization Is Higher in Exercise-Trained vs. Untrained Obese Adults. Poster presentation, American Diabetes Association, New Orleans, Louisiana, June. ABSTRACT
  • Van Pelt DW, Guth LM, Horowitz JF. 2016. A Single Session of Exercise Initiates Adaptive Responses in Adipose Tissue That May Lead to Improvements in Inflammation And Adipose Tissue Vascularization. Poster presentation, American Diabetes Association, New Orleans, Louisiana, June. ABSTRACT
  • Ma D, Guth LM, Qi Y, Caruso M, Zhang X, Horowitz JF, Yi Z. 2016. Effect of Exercise on Skeletal Muscle Phosphoproteome in Obese Insulin Resistant Adults. Poster presentation, American Society for Mass Spectrometry, San Antonio, Texas, June. ABSTRACT
  • Guth LM, Van Pelt DW, Yi, Z and Horowitz JF. 2016. Systemic Fatty Acid Mobilization Rates Are Elevated in Endurance-Trained Obese/Overweight Adults, but Are Blunted the Day After Acute Exercise. Poster presentation, The Integrative Biology of Exercise VII, Phoenix, Arizona, November. ABSTRACT
  • Yuan F, Guth LM, Van Pelt DW, Jawanda HS, Horowitz JF. 2016. Human Serum Collected Immediately After Exercise Does Not Alter mRNA Expression Related to Fatty Acid Metabolism or Inflammation in Cultured 3T3-L1 Adipocytes. Poster presentation, The Integrative Biology of Exercise VII, Phoenix, Arizona, November. ABSTRACT
  • Van Pelt DW, Guth LM, Karabetsos KC, Horowitz JF. 2016. A Single Session of Aerobic Exercise Reduces Markers of Inflammation in Subcutaneous Adipose Tissue. Poster presentation, The Integrative Biology of Exercise VII, Phoenix, Arizona, November. ABSTRACT
  • Ludzki AC, Gillen JB, Guth LM, Karabetsos KC, Horowitz JF. 2016. Effect of Exercise on Adipose Tissue Responses to Short-term Overeating in Healthy Adults. Poster presentation, The Integrative Biology of Exercise VII, Phoenix, Arizona, November. ABSTRACT
  • Jawanda HS, Van Pelt DW, Guth LM, Horowitz JF. 2016. Endurance Exercise Training Decreases mRNA Expression of Inflammatory Genes in Peripheral Blood Mononuclear Cells in Overweight And Obese Adults. Poster presentation, The Integrative Biology of Exercise VII, Phoenix, Arizona, November. ABSTRACT
  • Gillen JB, Nelson RK, Van Pelt DW, Guth LM, Horowitz JF. 2016. Mild-Intensity Exercise Training Alters Skeletal Muscle Phospholipid Composition in Obese Adults. Poster presentation, The Integrative Biology of Exercise VII, Phoenix, Arizona, November. ABSTRACT
  • Schleh MW, Guth LM, Jing H, Horowitz JF. 2018. Exercise-Induced Energy Deficit Lowers Glycemia at Breakfast the Next Day, but Not Over 24-Hours. American College of Sports Medicine Annual Meeting, Minneapolis, MN, May. ABSTRACT
  • Ryan BR, Van Pelt DW, Guth LM, Ludzki AC, Gioscia-Ryan RA, Ahn C, Horowitz JF. 2018. Insulin Resistance and In Vivo Lipolytic Rate Are Positively Associated with Body Iron Stores in Obese Women. Submitted to American Diabetes Association, Orlando, Florida, June. ABSTRACT

Tammy Barnes, PhD (2014-2016)

  • Bodur C, Kazyken D, Huang K, Ekim Ustunel B, Siroky KA, Tooley AS, Gonzalez IE, Foley DH, Acosta-Jaquez HA, Barnes TM, Steinl GK, Cho KW, Lumeng CN, Riddle SM, Myers MG Jr, Fingar DC. 2018. The IKK-Related Kinases TBK1 Activates mTORC1 Directly in Response to Growth Factors and Innate Immune Agonists. EMBO J. 37(1):19-38.
  • Allison MC, Pan W, MacKenzie A, Patterson C, Shah K, Barnes T, Cheng W, Rupp A, Olson DP, Myers MG. 2018. Defining the Transcriptional Targets of Leptin Reveals a Role for Atf3 in Leptin Action. Diabetes.

Amy Rumora, PhD (2014-2016)

  • Hinder L, Park M, Rumora AE, Hur J, Eichinger F, Kretzler M, Brosius III FC, Feldman E. 2016. Pioglitazone Mediates Tissue-Specific Mitochondrial Gene Expression Changes in the Sciatic Nerve and Kidney of db/db Mice. Journal of Cell and Molecular Medicine. 21(9):2140-2152.
  • Rumora AE, Lentz SI, Hinder LM, Jackson SW, Valesano A, Levinson GE, Feldman EL. 2018. Dyslipidemia Impairs Mitochondrial Trafficking and Function in Sensory Neurons. FASEB J. 32:195-2017.
  • Hinder LM, Murdock BJ, Park M, Bender DE, O’Brien PD, Rumora AE, Hur J, Feldman EL. 2018. Transcriptional Networks of Progressive Diabetic Peripheral Neuropathy in the db/db Mouse Model of Type 2 Diabetes: An Inflammatory Story. Exp Neurol. March 2018. Epub ahead of print.

Mark Jimenez Canet, PhD (2014-2015)

  • Chen Z, Canet MJ, Sheng L, Jiang L, Xiong Y, Yin L, Rui L. 2015. Hepatocyte TRAF2 Promotes Insulin Resistance and Type 2 Diabetes in Mice with Obesity. Mol Metab. 4(12):951-60.

Lindsey Muir, PhD (2014–2015)

  • Muir LA, Neeley CK, Meyer KA, Baker NA, Brosius AM, Washabaugh AR, Varban OA, Finks JF, Zamarron BF, Flesher CG, Chang JS, DelProposto JB, Geletka L, Martinez-Santibanez G, Kaciroti N, Lumeng CN, O’Rourke RW. 2016. Adipose Tissue Fibrosis, Hypertrophy, and Hyperplasia: Correlations with Diabetes in Human Obesity. Obesity Biology and Integrated Physiology. 24:597-605.
  • Zammarron BF, Mergian TA, Cho KW, Martinez-Santibanez G, Luan D, Singer K, DelProposto JL, Geletka LM, Muir LA, Lemeng CN. 2016. Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice. Diabetes. 66(2):392-406.
  • Cho KW, Zamarron BF, Muir LA, Singer K, Porsche CE, DelProposto JB, Geletka L, Meyer KA, O’Rourke RW, Lumeng CN. 2016. Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance. J Immunol. 197(9):3650-3661.
  • Baker NA, Muir LA Washabaugh AR, Neely CK, Chen SY, Flesher CG, Vorwold J, Finks JF, Ghaferi AA, Mulholland MW, Varban OA, Lumeng NC, O’Rourke RW. 2017. Diabetes-Specific Regulation of Adipocyte Metabolism by the Adipose Tissue Extracellular Matrix. J Clin Endocrinol Metab. 103(3):1032-1043.
  • Muir LA, Baker NA, Washabaugh AR, Neeley CK, Flesher CG, DelProposto JB, Geletka LM, Ghaferi AA, Finks JF, Singer K, Varban OA, Lumeng CN, O’Rourke RW. 2017. Adipocyte Hypertrophy-Hyperplasia Balance Contributes to Weight Loss After Bariatric Surgery. Adipocyte. 6(2):134-140.
  • Baker NA, Muir LA, Lumeng CN, O’Rourke RW. 2017. Differentiation and Metabolic Interrogation of Human Adipocytes. Methods Mol Biol. 1566:61-76.
  • Muir LA, Kiridena S, Griffin C, DelProposto JB, Geletka L, Martinez-Santibanez G, Zamarron BF, Lucas H, Singer K, O’Rourke RW, Lumeng CH. 2018. Rapid Adipose Tissue Expansion Triggers Unique Proliferation and Lipid Accumulation Profiles in Adipose Tissue Microphages. J Leukoc Biol. 2018:1-15.