Presentations & Posters

2019 American Society of Nephrology (ASN) Kidney Week

Below are the Michigan Medicine physicians and researchers who are participating in the 2019 American Society of Nephrology (ASN) Kidney Week taking place November 5 - 10, 2019 in Washington, DC.
 

Committee Members, Chairs, Moderators

ASN Kidney Week Planning Committee

Subramaniam Pennathur (Committee Member)

Tuesday, November 5 – Wednesday, November 6

Critical Care Nephrology: 2019 Update (Early Program)
Michael Heung (Co-Chair)
November 5 (7:00 AM - 06:00 PM) | November 6 (7:30 AM - 06:00 PM)

Advances in Research Conference: Machine Learning and Kidney Diseases (Early Program)
Matthias Kretzler (Co-Chair)
November 5 (7:00 AM - 06:00 PM) | November 6 (7:00 AM - 06:00 PM)

Thursday, November 7

Unraveling Connections Between Obesity and Kidney Diseases
Subramaniam Pennathur (Moderator)
2:00 – 4:00 PM

AKI: Mechanisms of Injury and Repair
Joel Weinberg (Moderator)
4:30 - 6:30 PM

Friday, November 8

Functional Proteomics: Unraveling Molecular Machines to Protein Networks in Metabolic Disease”
Anna Mathew (Moderator)
10:30 AM - 12:30 PM

Hope on the Horizon: Novel Therapeutics for Glomerular Disease
Markus Bitzer (Moderator)
2:00 – 4:00 PM

Saturday, November 9

The Right Tools for the Job: Model Systems for Glomerular Disease
Puneet Garg (Moderator)
2:00 – 4:00 PM

Sunday, November 10

Beating the Law of Averages: Predicting Diabetic Kidney Disease Outcomes Through Integrative Biology
Jennifer Harder (Moderator)
10:00 AM – 12:00 PM

Speakers

Tuesday, November 5

Kidney Transplantation (Early Program)
Outcomes, Risk Assessment, and Ethical Considerations for the Living Kidney Donor
Mona Doshi
4:30 – 5:00 PM

Real-Life Cases and Questions and Answers
Mona Doshi
5:30 – 6:00 PM

Wednesday, November 6

Advances in Research Conference Day 2: Machine Learning & Kidney Diseases (Early Program)
Targeted Therapeutics: Matching Patients to Trials
Matthias Kretzler
9:00 – 10:00 AM

Thursday, November 7

MBD Guidelines and Quality Improvement Program: Anything Changed in Clinical Practice?
Rajiv Saran
1:15 - 1:35 PM

Indications and Goals of Treatment in FSGS
Laura Mariani
1:15 - 1:35 PM

Obesity, Podocyte Depletion, and Risk for Allograft Loss
Abhijit Naik
2:30 – 3:00 PM

Characterization of Nephrotic Syndrome: What Are We Learning from Deep Learning?
Laura Mariani
2:30 – 3:00 PM

Modeling the Renal Epithelial-Microvascular Niche with Perfusable Pericyte-Lined Capillary Networsk in Vitro
Jeffrey Beamish
4:42 - 4:54 PM

Friday, November 8

Outcomes of AKI Patients Receiving Dialysis in ESRD Facilities
Jonathan Segal
5:42 - 5:54 PM

Saturday, November 9

Oxidative Metabolism Reprogramming in AKI
Joel Weinberg
2:00 - 2:30 PM

Lipid Remodeling in CKD
Farsad Afshinnia
3:00 - 3:30 PM

Sunday, November 10

Unraveling Molecular Mechanisms of Diabetic Kidney Disease for Therapeutic Target Characterization
Matthias Kretzler
10:30 AM - 11:00 AM

Oral Abstracts

Friday, November 8

Integrative analysis of single cell and bulk transcriptomic data identifies FSGS subgroup with endothelial cell activation
Rajasree Menon, Jennifer Harder, Brad Godfrey, Viji Nair, Matthias Kretzler, Edgar Otto, Sean Eddy, Laura Mariani, Celine Berthier, Felix Eichinger, Wenjun Ju
Session Title: New Techniques and Breakthroughs in Renal Pathology
5:30 PM to 5:42 PM

A Metabolomics-Based Pathway Analysis for How Dapagliflozin May Slow Kidney Function Decline in Patients with Type 2 Diabetes
Skander Mulder, Viji Nair, Wenjun Ju
Session Title: Translating Discovery to Patients with Diabetic Kidney Disease
5:30 PM to 5:42 PM

Regional Transcriptomic Profiling of the Human Kidney Uncovers Major Signature Shifts in the Interstitium During Diabetes
Rajasree Menon, Edgar Otto
Session Title: Diabetic Kidney Disease: Basic
5:54 PM to 6:06 PM

Risk Factors for Infection in Patients with Glomerular Disease: An Analysis of the Cure Glomerulonephropathy (CureGN) Study
Laura Mariani
Session Title: Lupus and Then Some
6:18 PM to 6:30 PM

Saturday, November 9

Identification of dicarbonyl and L-xylulose reductase (DCXR) as a therapeutic target in human chronic kidney disease
Wenjun Ju, Rajasree Menon, Matthias Kretzler
Session Title: Identification of Dicarbonyl and L-Xylulose Reductase (DCXR) as a Therapeutic Target in Human CKD
4:30 PM to 4:42 PM

Serum transforming growth factor 1 is a sex-specific risk factor for accelerated GFR decline in the general population
Jon Norvik, Wenjun Ju, Viji Nair, Matthias Kretzler, Bjørn O Eriksen, Toralf Melsom
Session Title: Women's Health and Kidney Diseases
5:06 PM to 5:18 PM

RNA Sequencing of Microdissected Kidney Biopsies Differentiates HIV+ FSGS from HIV-Negative FSGS
Brad Godfrey, Felix Eichinger
Session Title: Glomerular Diseases: Immunology, Inflammation - I
6:18 PM to 6:30 PM

Posters

Thursday, November 7

Kidneys from African American (AA) Donors Are Associated with Accelerated Podocyte Detachment After Kidney Transplantation
Abhijit Naik
Session Title: Transplantation: Clinical - Pretransplant Management
10:00 AM to 12:00 PM

Living Kidney Donation Is Accompanied by Persistently Increased Urine Pellet Nephrin mRNA in the First Year Post-Donation
Abhijit Naik
Session Title: Transplantation: Clinical - Pretransplant Management
10:00 AM to 12:00 PM

Longitudinal and Cross-Sectional Analysis of Kidney Transplant Urine mRNAs Reveals Glomerular Disease as an Important Driver of Long-Term Graft Loss
Abhijit Naik
Session Title: Transplantation: Clinical - Predictors of Outcomes - Biomarkers and Beyond
10:00 AM to 12:00 PM

Early Post Donation Hyperfiltration Is Associated with Accelerated Podocyte Detachment
Abhijit Naik
Session Title: Transplantation: Clinical - Pretransplant Management
10:00 AM to 12:00 PM

Pruritus and Mortality in Hemodialysis Patients: Results from the International DOPPS
Nidhi Sukul
Session Title: Hemodialysis and Frequent Dialysis - II
10:00 AM to 12:00 PM

The Kidney Precision Medicine Project (KPMP)
Matthias Kretzler
Session Title: Informational Posters - I
10:00 AM to 12:00 PM

Implications of Different Methods for Calculating Time to Percent eGFR Decline Outcomes
Maria Larkina, Laura Mariani, Wenjun Ju, Viji Nair
Session Title: CKD: (Non-Dialysis): Clinical, Outcomes, and Trials - I
10:00 AM to 12:00 PM

TGFBI and Kidney Disease Progression
Wenjun Ju, Matthias Kretzler, Debra L Walter, Sean Eddy, Viji Nair, Rajasree Menon
Session Title: CKD: Mechanisms - I
10:00 AM to 12:00 PM

Optimizing Machine Learning Methods for Clinical Outcome Prediction
Laura Mariani
Session Title: CKD: Risk Scores and Translational Epidemiology
10:00 AM to 12:00 PM

A novel deep learning model outperforms Cox regression model to predict renal and cardiovascular risk in patients with diabetic kidney disease
Wenjun Ju
Session Title: Diabetic Kidney Disease: Basic-I
10:00 AM to 12:00 PM

Multi-omics data integration identifies molecular pathways associated with renal response to atrasentan
Wenjun Ju, Hiddo Viji Nair, Matthias Kretzler
Session Title: Diabetic Kidney Disease: Biomarkers, Pathogenesis
10:00 AM to 12:00 PM

Stakeholder Perspectives on Implementing Precision Medicine in Diabetic Kidney Diseases
Matthias Kretzler
Session Title: Diabetic Kidney Disease: Biomarkers, Pathogenesis
10:00 AM to 12:00 PM

Association Between Histologic Variants of Focal Segmental Glomerulosclerosis and Outcomes: Results from the Japan Renal Biopsy Register
Takaya Ozeki
Session Title: Glomerular Diseases: Clinical, Outcomes, and Trials
10:00 AM to 12:00 PM

Can Estimated Glomerular Filtration Rate (eGFR) Slope Be a Good Outcome Measure for Glomerular Disease?
Laura Mariani
Session Title: Glomerular Diseases: Epidemiology, Mechanisms, Complications, Outcomes
10:00 AM to 12:00 PM

Differences in Disease Activity by Sex and Pubertal/Menopausal Status in Primary Glomerulonephropathies
Laura Mariani
Session Title: Glomerular Diseases: Epidemiology, Mechanisms, Complications, Outcomes
10:00 AM to 12:00 PM

Functional Subclasses of Nephrotic Syndrome Identified Using Consensus Non-Negative Matrix Factorization Clustering of Kidney Tubulointerstitial Tissue Transcriptome
Sean Eddy, Matthias Kretzler, Laura Mariani
Session Title: Glomerular Diseases: Epidemiology, Mechanisms, Complications, Outcomes
10:00 AM to 12:00 PM

Nephrotic Syndrome Acquired Hypercoagulopathy is Strongly Associated with Proteinuria and Hyperlipidemia
Matthias Kretzler
Session Title: Glomerular Diseases: Epidemiology, Mechanisms, Complications, Outcomes
10:00 AM to 12:00 PM

Association Between Kidney Tissue Estrogen Gene Signature and Nephrotic Syndrome Remission
Tiffany Rose Bellomo, John Hartman, Matthias Kretzler, Maria Larkina, Laura Mariani
Session Title: Glomerular Diseases: Minimal  Change Disease, FSGS, IgAN
10:00 AM to 12:00 PM

Clinical Outcome and Molecular Profile of Perihilar FSGS Are Similar to Other FSGS Subtypes
Neal Doshi, Maria Larkina, Sean Eddy, Matthias Kretzler, Laura Mariani
Session Title: Glomerular Diseases: Minimal  Change Disease, FSGS, IgAN
10:00 AM to 12:00 PM

The Incidence and Timing of Infectious Complications Relting to Immunosuppressive Treatment Among Adult Japenses Minimal Change Disease and Fogal Segmental Glomerulosclerosis: A Retrospective Study
Takaya Ozeki
Session Title: Glomerular Diseases: Minimal  Change Disease, FSGS, IgAN
10:00 AM to 12:00 PM

The Levels of Plasma suPAR May Not Discriminate the Patients with Poor Therapeutic Reactivity Among Adult Japanese Focal Segmental Glomerulosclerosis and Minimal Change Disease
Takaya Ozeki
Session Title: Glomerular Diseases: Minimal  Change Disease, FSGS, IgAN
10:00 AM to 12:00 PM

PAR-CLIP Identification of Cell Type and Context Specific miRNA:mRNA Interactions
Debra Walter
Session Title: Glomerular Diseases: Podocyte Biology - I
10:00 AM to 12:00 PM

University of Michigan O'Brien Kidney Translational Core Center
Matthias Kretzler, Wenjun Ju
Session Title: Informational Posters - I
10:00 AM to 12:00 PM

Friday, November 8

Identification of gene signatures and molecular pathways associated with UACR response to renal protective drugs
Wenjun Ju, Matthias Kretzler, John Hartman, Viji Nair
Session Title: Diabetic Kidney Disease: Basic - II
10:00 AM to 12:00 PM

The Use of Quantitative Morphometrics in Nephrectomy Specimens to Understand Focal Segmental Glomerulosclerosis
Jennifer Schaub
Session Title: Pathology and Lab Medicine: Clinical
10:00 AM to 12:00 PM

Preclinical Studies on N-Acetylmannosamine (ManNAc) for Glomerular Diseases
Matthias Kretzler
Session Title: Glomerular Diseases: Immunology, Inflammation - I
10:00 AM to 12:00 PM

A Novel Role for NPY-NPY2R Signalling in Albuminuric Kidney Disease
Viji Nair, Wenjun Ju, Matthias Kretzler
Session Title: Diabetic Kidney Disease: Basic
10:00 AM to 12:00 PM

Genome-Wide Association Study for AKI in the ASSESS-AKI Study
Jennifer Schaub
Session Title: AKI: Mechanisms - Inflammation/Sepsis/Remote Injury
10:00 AM to 12:00 PM

Variable penetrance of the therapy-resistant phenotype among children with genetic form of nephrotic syndrome
Jennifer Lai Yee, Damian Fermin, Virginia Vega-Warner
Session Title: Genetic Diseases of the Kidney - II
10:00 AM to 12:00 PM

Preclinical Studies on N-Acetylmannosamine (ManNAc) for Glomerular Diseases
Matthias Kretzler
Session Title: Glomerular Diseases: Immunology, Inflammation - I
10:00 AM to 12:00 PM

The Renal Pre-Competitive Consortium (RPC2) as a mechanism to bridge the translational gap for molecular target and biomarker identification in renal diseases
Mark Tomilo, Matthias Kretzler, Heather Ascani, Viji Nair, Sean Eddy, Wenjun Ju
Session Title: CKD (Non-Dialysis)
12:00 PM to 2:00 PM

Saturday, November 9

Hypertension Is Associated with Podocyte Hypertrophic Stress and Detachment Among a Healthy Living Donor Cohort
Abhijit Naik
Session Title: Hypertension and CVD: Mechanisms
10:00 AM to 12:00 PM

Nephrotic Syndrome Study Network (NEPTUNE)
Matthias Kretzler
Session Title: Glomerular Diseases
10:00 AM to 12:00 PM

Glomerular Gene Coexpression Networks Suggest Pathogenic Mechanisms in a Mouse Model of HIV-Associated Nephropathy
Viji Nair, Matthias Kretzler
Session Title: Glomerular Diseases: Immunology, Inflammation - II
10:00 AM to 12:00 PM

APOL1 and JAK1/2 Are Required for Interferon gamma-stimulated Inflammatory Responses in Human Kidney Cells
V. Vega-Warner , Wenjun Ju
Session Title: Glomerular Diseases: Immunology, Inflammation - II
10:00 AM to 12:00 PM

Unraveling the Genetic Contributions to Kidney Disease with the Kidney Genome Atlas
Matthias Kretzler
Session Title: 1002 Genetic Diseases of the Kidneys: Non-Cystic
10:00 AM to 12:00 PM

Anti-KITLG Therapy in Renal Injury
Debra Walter, Wenjun Ju
Session Title: Glomerular Diseases: Fibrosis, Extracellular Matrix
10:00 AM to 12:00 PM

Pediatric Nephrology Presentations and Posters

Speakers

Thursday, November 7

Clinical Trials in Glomerular Disease: Famine to Feast?
Debbie Gipson
4:30 PM - 6:30 PM

Posters

Thursday, November 7

Anticoagulation and Anti-Platelet Prescribing in Glomerular Disease: An Observational Study
Sharon Adler and Jonathan Troost
10:00 AM to 12:00 PM

Mood, Anxiety, and Hyperactivity Disorders in Patients with Glomerular Disease
Hailey Desmond, MS and Jonathan Troost
10:00 AM to 12:00 PM

Development of a Clinician-Reported Outcome Measure for Edema Assessment
Debbie Gipson and Noelle Carlozzi
10:00 AM to 12:00 PM

FSGS-MCD Patient Reported Outcome Measure (PRO) Development
Debbie Gipson and Noelle Carlozzi
10:00 AM to 12:00 PM

Kidney Research Network (KRN)
Jonathan Troost and Debbie Gipson on behalf of the Kidney Research Network
10:00 AM to 12:00 PM

State-Level Kidney Disease Surveillance Using Medicaid Data in Michigan and California
Zubin Modi
CKD: Risk Scores and Translational Epidemiology
10:00 AM to 12:00 PM 

Nephrotic Syndrome Acquired Hypercoagulopathy Is Strongly Associated with Proteinuria and Hyperlipidemia
Jonathan Troost
10:00 AM to 12:00 PM

Implications of Different Methods for Calculating Time to Percent eGFR Decline Outcomes
Jonathan Troost
10:00 AM to 12:00 PM

Incremental Reduction of Proteinuria and Kidney Survival in FSGS
Jonathan Troost
10:00 AM to 12:00 PM

Clinical Trials in Glomerular Disease: Famine to Feast?
Debbie Gipson
Clinical Trials in FSGS: Opportunities and Challenges
06:00 PM - 06:30 PM

Saturday, November 9

A Phase 2 Multicenter, Open Label, Randomized Study of Two Titration Regimens of Oral CXA-10 in Subjects with Primary Focal Segmental Glomerulosclerosis (FSGS). (FIRSTx)
Jonathan Troost and Debbie Gipson
10:00 AM to 12:00 PM