New State-of-the-Art Review Published in The British Medical Journal

Antiphospholipid Syndrome: Advances in Diagnosis, Pathogenesis, and Management

Authors: Jason S. Knight, D. Ware Branch, Thomas L. Ortel

Prothrombotic Autoantibodies in Serum from Patients Hospitalized with COVID-19

Prothrombotic Autoantibodies in Serum from Patients Hospitalized with COVID-19, published in Science Translational Medicine in November 2020, has been featured in over 110 news outlets.

Recent Publications

Non-Pharmacological Rehabilitation Interventions for Individuals with Antiphospholipid Syndrome: A Scoping Review
Alexandra E Harper, Yen T Chen, Stephanie Tancer, Kyla R Rodgers, Amber D Crumb, Whitney A Townsend, Jason S Knight, Susan L Murphy. Lupus. December 19, 2023

Inhibition of Neutrophil Extracellular Trap Formation Alleviates Vascular Dysfunction in Type 1 Diabetic Mice
Chao Liu, Srilakshmi Yalavarthi, Ajay Tambralli, Lixia Zeng, Christine E Rysenga, Nikoo Alizadeh, Lucas Hudgins, Wenying Liang, Somanathapura K NaveenKumar, Hui Shi, Miriam A Shelef, Kevin B Atkins, Subramaniam Pennathur, Jason S Knight. Science Advances. October 25, 2023

Taxifolin Inhibits NETosis Through Activation of Nrf2 and Provides Protective Effects in Models of Lupus and Antiphospholipid Syndrome
Christine E Rysenga, Linda May-Zhang, Miela Zahavi, Jason S Knight, Ramadan A Ali. Rheumatology (Oxford Academic). October 10, 2023

Interaction of the Antiphospholipid Syndrome Autoantigen Beta-2 Glycoprotein I with DNA and Neutrophil Extracellular Traps
Katarína Kmeťová, Elena Lonina, Srilakshmi Yalavarthi, Jerrold S Levine, Claire K Hoy, Cyrus Sarosh, Kelsey Gockman, Alexandra E Morris, Ajay Tambralli, Jacqueline A Madison, Yu Zuo, Rebecca Subang, Joyce Rauch, Jason S Knight. Clinical Immunology. October, 2023

Ginger Intake Suppresses Neutrophil Extracellular Trap Formation in Autoimmune Mice and Healthy Humans
Ramadan A. Ali, Valerie C. Minarchick, Miela Zahavi, Christine E. Rysenga, Kristin A. Sturm, Claire K. Hoy, Cyrus Sarosh, Jason S. Knight, and M. Kristen Demoruelle. JCI Insight. September 22, 2023

Associations Among Antiphospholipid Antibody Types, Isotypes, and Titers: An AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Study
Elena Gkrouzman, Rohan Willis, Danieli Andrade, Maria G Tektonidou, Vittorio Pengo, Guillermo Ruiz-Irastorza, H Michael Belmont, Paul R Fortin, Maria Gerosa, Flavio Signorelli, Tatsuya Atsumi, D Ware Branch, Cecilia Nalli, Esther Rodriguez-Almaraz, Michelle A Petri, Ricard Cervera, Jason S Knight, Maria Efthymiou, Hannah Cohen, Maria Laura Bertolaccini, Doruk Erkan, Robert Roubey, on behalf of APS ACTION. Laboratory Investigation. April 10, 2023

Prevalence of Antiphospholipid Antibodies and Association With Incident Cardiovascular Events
Yu Zuo, Sherwin Navaz, Wenying Liang, Chun Li, Colby R Ayers, Christine E Rysenga, Alyssa Harbaugh, Gary L Norman, E Blair Solow, Bonnie Bermas, Oludamilola Akinmolayemi, Anand Rohatgi, David R Karp, Jason S Knight, James A de Lemos. JAMA Netw Open. April 4, 2023

Antiphospholipid Syndrome Management: a 2023 Update and Practical Algorithm-Based Approach
Ambati, Amala; Knight, Jason S.; Zuo, Yu. Current Opinion in Rheumatology. March 3, 2023

Anti-NET Antibodies in Antiphospholipid Antibody-Positive Patients: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository
Yu Zuo MD, Sherwin Navaz BS, Alex Tsodikov PhD, Katarina Kmetova MS, Lyndsay Kluge, Amala Ambati MD, Claire K. Hoy BS, Srilakshmi Yalavarthi MS, Danieli de Andrade MD, PhD, Maria G. Tektonidou MD, PhD, Savino Sciascia MD, PhD, Vittorio Pengo MD, Guillermo Ruiz-Irastorza MD, H. Michael Belmont MD, Maria Gerosa MD, PhD, Paul R. Fortin MD, Guilherme Ramires de Jesus MD, D. Ware Branch MD, Laura Andreoli MD, PhD, Esther Rodriguez-Almaraz MD, Michelle Petri MD, Ricard Cervera MD, Rohan Willis MD, David R. Karp MD, PhD, Quan-Zhen Li MD, PhD, Hannah Cohen MD, Maria Laura Bertolaccini PhD, Doruk Erkan MD, Jason S. Knight MD, PhD, on behalf of APS ACTION. Arthritis & Rheumatology. March 2, 2023

An Update on Inflammation in Antiphospholipid Syndrome
Ambati, Amala; Zuo, Yu; Knight, Jason S. Current Opinion in Rheumatology. March 2023