Clinical Studies

The Division of Rheumatology conducts and participates in a number of clinical studies.

Antiphospholipid Syndrome (APS) Clinical Studies

ANSWERS Study
This observational study is being conducted with the goal of developing better treatments, and ultimately a cure, for APS. Individuals who agree to participate will have the opportunity to donate blood for cutting-edge genetic, transcriptomic, and metabolomic analyses. Participants will also be kept up-to-date on all the newest APS advances and research at University of Michigan.
Questions: michiganANSWERS@med.umich.edu or 734-647-3949
Principal Investigator: Jason S. Knight, MD, PhD
 
Phenotyping Endothelial Cells in APS
This study is being conducted with the goal of developing more precise and individualized treatments for APS. Specifically, we are isolating endothelial (blood vessel) cells from the skin of APS patients to determine why these cells do not function normally. We are especially interested in studying patients with livedo reticularis, a common APS-associated skin rash caused by slow-moving blood flow in vessels near the surface of the skin.
Questions: michiganANSWERS@med.umich.edu or 734-647-3949
Principal Investigator: Jason S. Knight, MD, PhD 
 
APS ACTION International Clinical Database and Repository
This is a multi-center collaborative effort to maintain a secure, web-based clinical database of persistently antiphospholipid antibody-positive individuals so that the natural course of these patients can be followed over the next 10 years.
Questions: michiganANSWERS@med.umich.edu or 734-647-3949
Site Principal Investigator: Jason S. Knight, MD, PhD
 
IMPACT (IMProve Pregnancy in APS with Certolizumab Therapy) Study
This treatment trial evaluates the addition of an anti-tumor necrosis factor-alpha drug, certolizumab, to usual treatment (a heparin agent and low-dose aspirin) in pregnant women with antiphospholipid syndrome (APS) and repeatedly positive tests for lupus anticoagulant (LAC) to determine if this regimen will improve pregnancy outcomes.
Questions: michiganANSWERS@med.umich.edu or 734-647-3949
Site Principal Investigator: Jason S. Knight, MD, PhD