About Our Lab
Antiphospholipid syndrome (APS) is an unpredictable, chronic autoimmune disease that can cause dangerous clots to form in the body's blood vessels. An estimated 200,000 people in the United States have this condition that leads to serious and sometimes life-threatening complications including stroke, heart attack, and pregnancy-related problems such as miscarriage or premature birth.
Our team, along with many collaborators across Michigan Medicine, are working to advance the understanding of the disease process and identify new, sophisticated approaches to the treatment of APS that are both personalized and proactive. We are also taking what we learn about blood clotting in APS and applying that knowledge to other diseases including lupus, diabetes, and COVID-19.
Dr. Jason Knight and Dr. Yu (Ray) Zuo give a virtual tour of their lab and discuss their research work on APS and COVID-19.
The patients in our APS clinic help to accelerate our research and are our most important partners in our fight against APS. Patients seen in our clinic are given the opportunity to be a part of our ANSWERS study, a prospective cohort study in which we regularly sample blood in pursuit of deep molecular phenotyping. Blood samples are taken to our lab, where we study the process of how antiphospholipid antibodies accelerate blood clotting. We believe this study will eventually allow us to treat patients before their first blood clot even happens.
Please visit the Antiphospholipid Syndrome Program section on UofMHealth.org to learn about APS and how to make an appointment at our clinic.
PROTHROMBOTIC AUTOANTIBODIES IN SERUM FROM PATIENTS HOSPITALIZED WITH COVID-19
Prothrombotic Autoantibodies in Serum from Patients Hospitalized with COVID-19, published in Science Translational Medicine in November 2020, has been featured in over 100 news outlets.
To make a gift to support our COVID-19 research, please visit: COVID-19 Research Fund (Knight Lab).
To make a gift to support our APS research, please visit: APS Gift Fund (Knight Lab).
- Non-Criteria Manifestations of Pediatric APS Common Yet ‘Under-Recognized’. Healio Rheumatology. May 20, 2022
Kids with Rare Autoimmune Disease Show These Symptoms Before Blood Clots. Michigan Medicine Health Lab. March 21, 2022
Rogue Antibodies Make Cells “Sticky” to Trigger Blood Clots in COVID-19 Patients. Michigan Medicine Health Lab. February 17, 2022
- Pediatric Antiphospholipid Syndrome: Clinical Features and Therapeutic Interventions in a Single Center Retrospective Case Series. Pediatric Rheumatology. February 23, 2022
- Endothelial Cell-Activating Antibodies in COVID-19. Arthritis & Rheumatology. February 17, 2022
- Mechanisms of Immunothrombosis and Vasculopathy in Antiphospholipid Syndrome. Seminars in Immunopathology. February 4, 2022