Jason Knight Lab

About Our Lab

Antiphospholipid syndrome (APS) is an unpredictable, chronic autoimmune disease that can cause dangerous clots to form in the body's blood vessels. An estimated 200,000 people in the United States have this condition that leads to serious and sometimes life-threatening complications including stroke, heart attack, and pregnancy-related problems such as miscarriage or premature birth.

Our team, along with many collaborators across Michigan Medicine, are working to advance the understanding of the disease process and identify new, sophisticated approaches to the treatment of APS that are both personalized and proactive. We are also taking what we learn about blood clotting in APS and applying that knowledge to other diseases including lupus, diabetes, and COVID-19.

This is what clotting looks like.

Dr. Jason Knight and Dr. Yu (Ray) Zuo give a virtual tour of their lab and discuss their research work on APS and COVID-19.

The patients in our APS clinic help to accelerate our research and are our most important partners in our fight against APS. Patients seen in our clinic are given the opportunity to be a part of our ANSWERS study, a prospective cohort study in which we regularly sample blood in pursuit of deep molecular phenotyping. Blood samples are taken to our lab, where we study the process of how antiphospholipid antibodies accelerate blood clotting. We believe this study will eventually allow us to treat patients before their first blood clot even happens.

Watch Dr. Knight's lecture "What Can Queen Anne’s Lupus Teach Us About COVID-19?"

Click here to watch additional lectures given by Dr. Knight and his team.

Patient Inquiries

Please visit the Antiphospholipid Syndrome Program section on UofMHealth.org to learn about APS and how to make an appointment at our clinic.

Join Our Email List

If you are interested in receiving updates on our patient care and research efforts, please join our APS Program email list. Read the APS Program October 2021 Update.

U-M Division of Rheumatology, Dr. Jason Knight

Marvin and Betty Danto Research Professor
of Connective Tissue Research

Associate Professor, Department of Internal Medicine,
Division of Rheumatology

Associate DirectorLupus Program


UofMHealth.org Profile@jasonsknight


Prothrombotic Autoantibodies in Serum from Patients Hospitalized with COVID-19, published in Science Translational Medicine on November 2, is featured in over 95 news outlets.