Publications

Highlights

Targeting CD38-Dependent NAD+ Metabolism to Mitigate Multiple Organ Fibrosis
Bo Shi, Wenxia Wang, Benjamin Korman, Li Kai, Qianqian Wang, Jun Wei, Swarna Bale, Roberta Goncalves Marangoni, Swati Bhattacharyya, Stephen Miller, Dan Xu, Mahzad Akbarpour, Paul Cheresh, Daniele Proccissi, Demirkan Gursel, Jair Machado Espindola-Netto, Claudia C.S. Chini, Guilherme C. de Oliveira, Johann E. Gudjonsson, Eduardo N. Chini, John Varga. iScience. 2021 Jan 22; 24(1): 101902. PMCID: PMC7770554

TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skin and Lung
Swati Bhattacharyya, Wenxia Wang, Wenyi Qin, Kui Cheng, Sara Coulup, Sherry Chavez, Shuangshang Jiang, Kirtee Raparia, Lucia Maria V. De Almeida, Christian Stehlik, Zenshiro Tamaki, Hang Yin, John Varga. JCI Insight. 2018 Jul 12; 3(13): e98850. Published online 2018 Jul 12. doi: 10.1172/jci.insight.98850. PMCID: PMC6124522

Adipocyte-Specific Repression of PPAR-Gamma by NCoR Contributes to Scleroderma Skin
Fibrosis

Benjamin Korman, Roberta Goncalves Marangoni, Gabriel Lord, Jerrold Olefsky, Warren Tourtellotte, John Varga. Arthritis Res Ther. 2018; 20: 145. Published online 2018 Jul 11. doi: 10.1186/s13075-018-1630-z. PMCID: PMC6042240

Tenascin-C Drives Persistence of Organ Fibrosis
Swati Bhattacharyya, Wenxia Wang, Luisa Morales-Nebreda, Gang Feng, Minghua Wu, Xiaodong Zhou, Robert Lafyatis, Jungwha Lee, Monique Hinchcliff, Carol Feghali-Bostwick, Katja Lakota, G. R. Scott Budinger, Kirtee Raparia, Zenshiro Tamaki, John Varga. Nat Commun. 2016; 7: 11703. Published online 2016 Jun 3. doi: 10.1038/ncomms11703. PMCID:PMC4895803 

Myofibroblasts in Murine Cutaneous Fibrosis Originate from Adiponectin-Positive Intradermal Progenitors
Roberta Goncalves Marangoni, Benjamin D. Korman, Jun Wei, Tammara A. Wood, Lauren V. Graham, Michael L. Whitfield, Philipp E. Scherer, Warren G. Tourtellotte, John Varga. Arthritis Rheumatol. Author manuscript; available in PMC 2015 Jun 18. Published in final edited form as: Arthritis Rheumatol. 2015 Apr; 67(4): 1062–1073. doi: 10.1002/art.38990. PMCID:PMC4472310

The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling
Jun Wei, Archit K. Ghosh, Haiyan Chu, Feng Fang, Monique E. Hinchcliff, Jiucun Wang, Roberta Goncalves Marangoni, John Varga. Arthritis Rheumatol. Author manuscript; available in PMC 2015 Jul 29. Published in final edited form as: Arthritis Rheumatol. 2015 May; 67(5): 1323–1334. doi: 10.1002/art.39061. PMCID:PMC4518870 

FibronectinEDA Promotes Chronic Cutaneous Fibrosis Through Toll-like Receptor Signaling
Swati Bhattacharyya, Zenshiro Tamaki, Wenxia Wang, Monique Hinchcliff, Paul Hoover, Spiro Getsios, Eric S. White, John Varga. Sci Transl Med. Author manuscript; available in PMC 2015 Apr 29. Published in final edited form as: Sci Transl Med. 2014 Apr 16; 6(232): 232ra50. doi: 10.1126/scitranslmed.3008264. PMCID: PMC4414050 

A Synthetic Toll-Like Receptor 3 Ligand Mitigates Profibrotic Fibroblast Responses by Inducing Autocrine Interferon Signaling
Feng Fang, Kohtaro Ooka, Xiaoyong Sun, Ruchi Shah, Swati Bhattacharyya, Jun Wei, John Varga. J Immunol. Author manuscript; available in PMC 2014 Sep 15. Published in final edited form as: J Immunol. 2013 Sep 15; 191(6): 2956–2966. Published online 2013 Aug 16. doi: 10.4049/jimmunol.1300376. PMCID: PMC3924580 

Wnt/β-Catenin Signaling Is Hyperactivated in Systemic Sclerosis and Induces Smad-Dependent Fibrotic Responses in Mesenchymal Cells
Jun Wei, Feng Fang, Anna P. Lam, Jennifer L. Sargent, Emily Hamburg, Monique E. Hinchcliff, Cara J. Gottardi, Radhika Atit, Michael L. Whitfield, John Varga. Arthritis Rheum. Author manuscript; available in PMC 2013 Aug 1. Published in final edited form as: Arthritis Rheum. 2012 Aug; 64(8): 2734–2745. doi: 10.1002/art.34424. PMCID: PMC3553791