Achievements and News

News Spotlight

Exploring New Treatments for Autoimmune Diseases

Dinesh Khanna, MD, MSc; David Fox, MD; and J. Michelle Kahlenberg, MD, PhD awarded a NIH Autoimmunity Centers of Excellence (ACE) grant to explore personalized approaches to treating autoimmune diseases. Read more on Michigan Medicine Health Lab.
 
 

Publications

May 2019
David Roofeh, MD, who will join the Scleroderma Program in July 2019, writes a state-of-the-art review on the management of scleroderma-associated lung fibrosis. Read more

March 2019
Dinesh Khanna, MD, MSc, participates in an international consensus meeting to propose standard of care for the management of scleroderma. Read more.

February 2019
Dr. Khanna co-authors the updated Pulmonary Hypertension Association Pulmonary Hypertension & Scleroderma Brochure.

January 2019
Dr. Khanna publishes an updated version of the Scleroderma Foundation Digestive System Involvement in Scleroderma Medical Report.

February 2017
Dr. Khanna and colleagues publish "Standardization of the Modified Rodnan Skin Score for Use in Clinical Trials of Systemic Sclerosis" in the Journal of Scleroderma and Related Disorders.

July 2016
"Hand Impairment in Systemic Sclerosis: Various Manifestations and Currently Available Treatment" article was published by the UM Scleroderma Program and Occupational Therapy Division in the Department of Physical Medicine and Rehabilitation.

UM Scleroderma team leads a pilot study of pirfenidone in scleroderma-associated lung fibrosis. Read more

June 2016
UM Scleroderma Program publishes pilot study of acupressure in Raynaud’s phenomenon. Read more.

Dr. Khanna publishes "Emerging Strategies for Treatment of Systemic Sclerosis."

May 2016
UM Scleroderma Program Director is the lead author for 2 large clinical trials in scleroderma. Read more. Learn more about the "Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis".

Dr. Khanna publishes findings of the FaSScinate study in The Lancet. Learn more about the "Safety and Efficacy of Subcutaneous Tocilizumab in Adults with Systemic Sclerosis (faSScinate): A Phase 2, Randomised, Controlled Trial".

February 2016
Dr. Khanna and the UM Scleroderma Program led the development of the "American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis", which has the potential to revolutionize the conduct of clinical trials in systemic sclerosis. Supplemental material.

Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis

September 2014
"Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Gastrointestinal Symptom Scales", co-written by Dr. Dinesh Khanna, is published in The American Journal of Gastroenterology.

April 2014
"Targeting the Myofibroblast Genetic Switch: Inhibitors of MRTF/SRF-regulated Gene Transcription Prevent Fibrosis in a Murine Model of Skin Injury", The Journal of Pharmacology and Experimental Therapeutics.

December 2013
"Recommendations for Screening and Detection of Connective Tissue Disease-Associated Pulmonary Arterial Hypertension".

Invited Lectures & Workshops

March 2019
Dr. Khanna gives an Update on Scleroderma to rheumatologists at the NYU Langone Seminar in Advanced Rheumatology on March 16th. View schedule.

October 2018
Dr. Khanna is an invited speaker at the 55th Annual André Aisenstadt Memorial Clinical Day in Montreal, Canada to honor the achievements of Dr. Murray Baron. View schedule.

September 2018
Dr. Khanna was an invited guest at the Emirates Society of Rheumatology and American College of Rheumatology meeting in Dubai, UAE. Speakers included (L to R): Dr. Nigrovic, Dr. Khanna, Dr. Petri, Dr. Daikh, Dr. Lakhanpal, Dr. Ritchlin, and Dr. O’Dell.

Emirates Society of Rheumatology and American College of Rheumatology meeting in Dubai

June 2018
Dr. Dinesh Khanna to speak at the Scleroderma Foundation’s National Patient Education Conference in July 2018.

May 2018
Dr. Dinesh Khanna is invited to chair the Monsoon Rheumatology Summit on scleroderma, which is taking place in Cochin, India, July 2018.

January 2018
Dr. Dinesh Khanna is a guest speaker on ReachMD and discusses managing patients with SS-ILD, Interstitial Lung Disease in Scleroderma: Early Recognition and Emerging Therapeutic Options.

August 2017
Dr. Khanna serves as a member of the Teaching Faculty at the 18th Singapore Society of Rheumatology-Malaysian Society of Rheumatology Workshops in Rheumatology 2017.

18th Singapore Society of Rheumatology-Malaysian Society of Rheumatology Workshops in Rheumatology

18th Singapore Society of Rheumatology-Malaysian Society of Rheumatology Workshops in Rheumatology

August 2016
Professor Khanna attends the First Scleroderma meeting arranged by the Indian Rheumatology Association in Bangalore, India.

Indian Rheumatology Association, 2016 Advanced Rheumatology Course

September 2015
Dr. Khanna speaks on Scleroderma at the Harvard Rheumatology CME Program.

The APLAR 2015 meeting, organized by the American College of Rheumatology, was held in Chennai, India.

Dr. Khanna at APLAR 2015 meeting

April 2015
Dr. Khanna presents at the 33rd Annual Carl M. Pearson Memorial Symposium.

February 2014
Dr. Khanna speaks at the 3rd Systemic Sclerosis World Congress in Rome, Italy. He also served on the Steering Committee.

3rd Systemic Sclerosis World Congress

August 2013
Dr Khanna invited to Hamilton, New Zealand to present at their annual rheumatology meeting. Dr. Khanna discussed the latest evidence in the management of pulmonary arterial hypertension and other topics on diagnosis and management of scleroderma.

June 2013
Dr. Khanna presented the first recommendations for screening and diagnosis of connective tissue disease-associated pulmonary arterial hypertension at the annual EULAR meeting in Madrid, Spain.

Meetings

September 2017
Doctors, professors, and professionals from the ASSET study met from around the world at the University of Michigan to discuss the progress of the study, as well as the successes of its collaboration.

Doctors, professors, and professionals from the ASSET study meet at U-M

December 2014
Meeting of the Prospective Registry of Systemic Sclerosis (PRESS) took place at the University of Michigan. The project spans 11 centers, and met to standardize and align research efforts in the various fields at each center.

In the News

May 2019
Dr. Dinesh Khanna, Dr. David Fox, and Dr. J. Michelle Kahlenberg awarded a NIH Autoimmunity Centers of Excellence (ACE) grant to explore personalized approaches to treating autoimmune diseases. "Exploring New Treatments for Autoimmune Diseases".

February 2019
Dr. Amber Young, Kate Homer, and Dr. Dinesh Khanna find that a significant proportion of patients have coexisting pulmonary hypertension that occurs early after SSc-ILD diagnosis. "Pulmonary Hypertension Often Occurs Early After SSc-ILD Diagnosis".

Results from clinical trials FaSScinate and FocuSSced, led by Dr. Dinesh Khanna, are recognized at the Basic and Clinical Immunology for the Busy Clinician symposium. "Tocilizumab Better Than Placebo in Preserving Forced Vital Capacity in Systemic Sclerosis".

Dr. Pei-Suen (Eliza) Tsou, Phillip Campbell, Dr. M. Asif Amin, Patrick Coit, Shaylynn Miller, Dr. David Fox, Dr. Dinesh Khanna, and Dr. Amr Sawalha discover a specific molecule that could be contributing to the progression of scleroderma in patients. "Inhibiting Cancer-Causing Protein Could Prevent Scleroderma Fibrosis".

January 2019
Dr. Dinesh Khanna, who led development of a novel, recently endorsed scleroderma outcome measure, discusses current and future clinical trials and treatments. "Systemic Scleroderma Treatments: Where Are We Now?"

July 2018
Dr. Dinesh Khanna and the Scleroderma Program team featured on Michigan Medicine Health Blog. “Living with Scleroderma: Personalized Treatment & Support Makes All the Difference”.

October 2017
Sheri Hicks, a patient of the U-M Scleroderma Program talks about her experience with the Scleroderma Program and Director, Dr. Dinesh Khanna, in USA Today. "Journey of Hope: Autoimmune Disease Patient Raises Funds, Promotes Education".

Dr. Dinesh Khanna featured in Michigan Medicine Headlines. Service Spotlight: Doc's Commitment to Patient ‘Priceless’.

July 2017
The STAR Trial of Habeo Cell Therapy in Patients with Scleroderma announces details and results from its study. This form of cell therapy appears to benefit patients with the diffuse form of the disease, representing a valuable new piece of information for the field. Learn more about the STAR trial and the announcement from Cytori.

June 2017
NIAMS (National Institute of Arthritis and Musculoskeletal and Skin Diseases) hosts a Twitter chat with experts from across the nation participating.

August 2015
The Prospective Registry of Systemic Sclerosis (PRESS) is featured in Scleroderma Voice magazine. The PRESS Registry recently received the Scleroderma Foundation Collaborative Research (SCORE) grant.

June 2015
"FDA Grants Breakthrough Therapy Designation for Actemra in Systemic Sclerosis".

January 2015
"Cytori and Leading Expert Discuss Importance of ‘STAR’ Trial and Treatment for Scleroderma Patients".

April 2014
"Scientists Find ‘Off’ Switch for Scleroderma". Discovery brings researchers one step closer to unraveling devastating disease.

"Flipping the Switch on Scleroderma". Colleagues from Michigan State University and the University of Michigan have identified the core signaling pathway that activates the disease and the chemical compounds that can turn it off.

October 2013
New scleroderma classification criteria published by ACE/ EULAR. Dr. Khanna participated and played a pivotal role in developing this criteria. Learn more.

Events

November 2018
The Scleroderma Program was selected to participate in Giving Blueday, the University of Michigan’s annual day of giving. Scheduled to coincide with Giving Tuesday, a global day of giving following Thanksgiving weekend, Giving Blueday is a day for everyone who loves Michigan to join together to combine their support and maximize impact.

June 2017
The Scleroderma Foundation Michigan Chapter hosted its annual Stampede Scleroderma event: a 5k at the Detroit Zoo to raise money for scleroderma research, support, and education.

June 2016
The Scleroderma Program hosted its Scleroderma Update event, where patients were able to talk to doctors and coordinators about the latest research. View pictures.

U-M Scleroderma Research team members participated in the 2016 Stampede Scleroderma Walk at the Detroit Zoo. As part of the event, a 10K run, 5K run, 1 mile run, and a Zoo walk were all offered to participants. There was a tremendous turnout for the event, and best of all, we missed the rain by minutes!

2016 Stampede Scleroderma Walk at the Detroit Zoo

Awards & Recognition

December 2017
Jody Fisher, Program Manager of the Scleroderma Program, is nominated for an Evan Newport HOPE Award.

February 2016
Eliza Tsou, PhD, receives the Marta Marx Fund for the Eradication of Scleroderma.

December 2015
Dinesh Khanna, MD, MSc, is awarded the American College of Rheumatology Henry Kunkel Young Investigator Award, which is part of the ACR Awards of Distinction, a series of awards given out annually to recognize its members’ contributions to the field of rheumatology. The Henry Kunkel Young Investigator Award is awarded to a young physician scientist, age 45 or younger by October 1 of the year in which they are nominated, who has made outstanding and promising independent contributions to basic or clinical research in the field of rheumatology.

August 2015
The Prospective Registry of Systemic Sclerosis (PRESS) is featured in Scleroderma Voice magazine. The PRESS Registry recently received the Scleroderma Foundation Collaborative Research (SCORE) grant.

January 2015
U-M researchers, Dinesh Khanna, MD, MSc and Cathie Spino, ScD, receive $7M to study scleroderma treatment.

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