JoAnn M. Sekiguchi, PhD

U-M Genetic Medicine Division, Dr. JoAnn Sekiguchi
JoAnn M. Sekiguchi, PhD

Associate Professor, Department of Internal Medicine
Associate Professor, Department of Human Genetics

Biomedical Science Research Building
109 Zina Pitcher Place, Room 2063
Ann Arbor, MI 48109
Phone: 734-764-9514


  • BA/BS (Psychology/Biochemistry), University of California, Davis, CA, 1987
  • PhD (Molecular Biology), Cornell University Graduate School of Medical Sciences, New York, NY, 1996
  • Postdoctoral Training (Molecular Biology), Sloan Kettering Institute, New York, NY, 1997
  • Postdoctoral Training (Immunology and Genetics), Harvard Medical School, Boston, MA, 2003

Research Interests

Research in the Sekiguchi lab focuses on elucidating the mechanisms and regulation of DNA repair processes in mammalian cells. The two major pathways of repair we study are DNA double strand break repair via the non-homologous end joining pathway and resolution of stalled or blocked replication forks via the Fanconi anemia pathway. Both pathways play critical roles in preventing accumulation of unwanted DNA damage and in maintaining the integrity of the genome. Studies in my lab take advantage of a combination of biochemical, molecular, cellular and genetic approaches to elucidate the roles of proteins in DNA repair and to determine the impact of defective repair on genome stability, immune system development, and tumorigenesis. We have generated several novel mouse models harboring gene-targeted null, hypomorphic knock-in and conditional alleles in genes known to be mutated in human immunodeficiency and/or cancer predisposition syndromes. Recent work has focused on identification of pathways required for repair of oncogene induced DNA damage and targeted inhibition of these pathways to selectively kill tumor cells overexpressing oncogenes. In addition, the lab is investigating effective therapeutic strategies for treating or attenuating disease symptoms caused by DNA repair deficiencies.


View all Dr. Sekiguchi's publications in PubMed.

Appointments & Honors

  • 1995: Frank Lappin Horsfall, Jr., Fellowship, Sloan Kettering Institute
  • 1998: Young Investigator Award; FASEB Summer Conference-Nucleic Acid Enzymes
  • 1999: Richard D. Frisbee III Foundation Fellow, Leukemia and Lymphoma Society
  • 2002: Ranadive Endowment Award, Leukemia and Lymphoma Society
  • 2003: Biomedical Sciences Scholars Award, University of Michigan
  • 2004: Pew Scholars Award in Biomedical Sciences, Pew Charitable Foundation
  • 2006: W.M. Keck Foundation Distinguished Young Scholars Semi-finalist
  • 2008: Elizabeth Caroline Crosby award, University of Michigan
  • 2009-2013: Member, University of Michigan Medical School, Biomedical Research Council
  • 2012-2017: Director, Graduate Studies; University of Michigan; Department of Human Genetics
  • 2013-present: Member, Molecular Genetics B Study Section - MGB
  • 2015-present: Chair, Human Genetics Graduate Education Committee; Department of Human Genetics
  • 2015-present: Member, Rackham Integrity Review Board; Rackham Graduate School; University of Michigan
  • 2016: Basic Sciences Teaching Award; Endowment for Basic Sciences; University of Michigan Medical School
  • 2017-present: Member, Chair’s Advisory Committee; Department of Human Genetics