The Altschuler Laboratory examines the cochlear response to stress and the intracellular molecular pathways that lead to protection, repair and recovery. Researchers also study how the central auditory pathways react and adapt to deafness at the genetic, molecular, neurochemical and morphological levels. Visit lab webpage.
The Basura Laboratory's research interests include: auditory cortex plasticity following hearing loss; central auditory neuroanatomy and neurophysiology; and the clinical specturm of neurotology, including cochlear implantation, hearing restoration and skull base tumors, including cutaneous peri-auricular malignancy. Visit lab webpage.
The Brenner Laboratory's research interests include: elucidating mechanisms of oxidative stress injury, cochlear reactive oxygen species formation and free radical mediated apoptosis and injury in the ear; neuropharmacology; ototoxicity and otoprotection; molecular targets for auditory hair cell protection; and translational research study of nerve regeneration, nerve reconstruction, axonal guidance, nerve transfer, senescence and tissue engineered constructs. Visit lab webpage.
The Carey Laboratory studies the basis for autoimmune hearing loss, including the detection of pathogenic antibodies, identification of the inner ear target antigen and development of new diagnostic tests. Visit lab webpage.
The Corfas Laboratory studies the molecular mechanisms involved in the development, function and maintenance of the nervous system and how to use this knowledge to understand nervous system disorders and develop new therapies to treat them. Visit lab webpage.
The Duncan Laboratory studies the excitability of sensory cells in the cochlea. The laboratory uses molecular biology, histology and electrophysiology to address the structure and function of hair cell ion channels. Researchers are particularly interested in mechanisms that regulate ion channel behavior, in the normal, regenerative and pathological cochlea. Visit lab webpage.
The King Laboratory studies the processing of neural signals in vestibular and oculomotor pathways using behavioral methods and signal cell neurophysiological recordings. The laboratory is particularly interested in the interplay between vestibular sensory and efference copy signals during actively coordinated eye and head movements and in ways to effectively evaluate otolith dysfunction in humans and animals exposed to damaging levels of noise. Visit lab webpage.
The Kohrman Laboratory is interested in the identification and analysis of genes affected in mouse models of inherited inner ear dysfunction. Visit lab webpage.
The Lesperance Laboratory identifies changes in genes that cause hearing loss by analyzing DNA. The lab also studies families with hearing loss in order to develop better ways to diagnose and treat genetic hearing loss. Visit lab webpage.
The Miller Laboratory aims to define new drug interventions that can prevent noise-induced hearing loss and treatments that can promote auditory nerve survival and regrowth after deafness (differentiation) to enhance the benefits of cochlear prostheses in the severely hearing impaired. Visit lab webpage.
The Papagerakis Laboratory seeks to understand the structural and functional consequences following disruption of the circadian clock genes in regard with the auditory system. Outstanding collaborative efforts at U-M and beyond are undergoing to understand the link between circadian gene networks and organ physiology, stem cell biology, inflammation and metabolic processes. Visit lab webpage.
The Pfingst Laboratory aims to understand the mechanisms of electrical hearing and to identify ways to improve speech recognition and quality of life for patients with auditory prostheses. Visit lab webpage.
The Raphael Laboratory studies repair and regeneration in the inner ear, tissue engineering technologies as applied to the cochlea and vestibular organs, and hereditary sensorineural deafness. Visit lab webpage.
The Roberts Laboratory investigates the cellular, synaptic, and network mechanisms used by neural circuits in the auditory system to extract and encode important features of sounds. Visit lab webpage.
The Schacht Laboratory investigates the biochemical and molecular events that regulate the normal function of the inner ear and the mechanisms by which drugs and noise can cause hearing loss. These studies lead to the design of protective therapies for drug- and noise-induced hearing loss. Visit lab webpage.
The Shore Laboratory studies neural connections from auditory and somatosensory nuclei to the cochlear nucleus and their role in the coding of complex sounds, as well as their role in neural plasticity and tinnitus. Visit lab webpage.