Shore Laboratory

Photomicrograph of an octopus cell labeled after an injection of fluorescent tracer into the adjacent posteroventral cochlear nucleus during a tract-tracing experiment

The Shore Laboratory has been studying the contributions of multisensory systems to auditory processing. In particular, we discovered that ‘touch-sensitive’ neurons in the brain, which receive input from the face and head, send neural projections to the auditory system. These projections terminate in the first stop in the brain, the cochlear nucleus, which receives input directly from the cochlea. Our work has shown that these ‘somatosensory’ neurons can alter the cochlear nucleus response to sound. These somatosensory neurons contribute to sound-localization coding. Most remarkably, after deafness, there is a strong enhancement in somatosensory influences on the cochlear nucleus, as if in compensation for the loss of input from the cochlea. An undesirable side effect of these somatosensory inputs, which are excitatory, is the development of tinnitus (ringing in the ear). Our previous work demonstrates that in animals with tinnitus (tested behaviorally), the major change in the cochlear nucleus was an increase in excitation from the somatosensory system.  Work extending these findings is now focused on synaptic plasticity as an underlying mechanism to explain the long-term nature of these changes. Ongoing work is laying the groundwork for treatments that include specific, patterned stimulation that may ‘reverse’ the increased excitation that contributes to tinnitus (see 2018 press release). 

Dr. Susan E. Shore, Ph.D.

Another focus of interest is sensory-motor integration in the cochlear nucleus. Ongoing work is seeking to identify and characterize neurons from the pontine nuclear complex to the cochlear nucleus and determine their role in sound localization and tinnitus. In addition to electrophysiology to study these neurons, we use tract tracing and optogenetics. Immunocytochemistry and genetic modifications of neurotransmitter systems are also employed to study mechanisms underlying tinnitus.

 

 


Featured News

CBS News-"Experimental device tested to help treat ringing in the ears"

Newsweek-"Tinnitus: New Device Targets Brain's Neurons to Treat Ringing in the Ears"

Chicago Tribune-"New hope for ringing in the ears"

Shore Laboratory Team

Adam Hockley

Adam Hockley

Adam Hockley is a first-year post-doc using in vivo recordings to study the physiology of the cochlear nucleus. His current interests lie in investigating how neural circuits in the auditory brainstem, including olivocochlear projections, contribute to hearing in normal and pathological systems. These circuits within the cochlear nucleus are altered after cochlear synaptopathy.  Further understanding of these circuits may explain how signals are extracted from background noise and how this ability is degraded after cochlear synaptopathy or ‘hidden hearing loss’. 

Lorraine Horwitz

Lorraine Horwitz

Neuroscience Graduate Student
BS: University of California, Riverside
PREP: University of Michigan

Lorraine Horwitz is interested in the neuronal mechanisms of an auditory hypersensitivity disorder known as hyperacusis, in which normal auditory stimuli are misperceived as too loud, uncomfortable, or even painful. To tackle this question, she is carefully dissecting how the auditory and somatosensory systems interact in the cochlear nucleus.

Other interests include: Running, rock climbing, baking, growing plants, hiking, and pampering her cat, Luna.

Gerilyn Jones

Research Fellow

Room 2335A Med Sci I

Karan Joseph

Karan Joseph, B.S.

Karan is an undergraduate at the University of Michigan studying neuroscience. The project he is involved with is investigating changes in acetylcholine levels in the cochlear nucleus before and after noise exposure and the development of tinnitus. 

David Martel

David Martel, MSE

David Martel is a PhD Candidate in the University of Michigan's Department of Biomedical Engineering, with undergraduate degrees in biomedical and electrical engineering. His interests include neurophysiology/engineering, machine learning and systems-level development. His experience broadly ranges from real time embedded systems and signal processing to biological modeling, electrophysiology and machine learning. His previous experiences have been in industry, developing embedded systems, and academia, researching how cochlear nucleus physiology is altered in tinnitus.

Michael Selesko

Michael Selesko

Michael Selesko is a Research Technician in the Shore Lab.  He received his bachelor's degree in Cell and Molecular Biology at the University of Michigan and his master's degree in Biomedical Engineering at Grand Valley State University.  His masters thesis investigated connectivity of brain regions before, during and after seizures in patients with refractory epilepsy using information theoretic techniques.  In the Shore Lab, he works on running behavior experiments and analyzing single unit recordings from the cochlear nucleus.  In addition, he is also interested in looking into the role of choline acetyltransferase in the cochlear nucleus and superior olivary complex.  

Katherine Thorne

Katherine Thorne

Undergraduate - Junior
Major - Neuroscience
September 2018 - Present

Katie Thorne works primarily with Lorraine Horwitz on establishing a mouse behavioral model of hyperacusis. She is studying neuroscience here at the University of Michigan with the intent of continuing her studies in graduate school.

Outside of the lab, Katie plays club water polo and enjoys the time that she can spend outside.

Travis Riffle

Research Fellow

Room 2335A Med Sci I

Calvin Wu

Calvin Wu, Ph.D.

Calvin Wu is a Research Investigator and received his PhD from University of North Texas, where he studied cellular and network physiology in developing cortical neurons in vitro. He joined the Shore Lab in 2013 to pursue his interest in sensory systems and circuits that regulate normal and abnormal perception. Specifically, he worked on 1) multisensory integration in inhibitory neurons in the cochlear nuclei and 2) electrophysiological correlates of tinnitus. Currently, he is applying statistical methods to examine dorsal cochlear nucleus circuit connectivity via simultaneous recording of spontaneous activity from different cell populations.