Thursday, March 9, 2023

Depression Phenotypes, Motivational Deficits and Precision Psychiatry

3:00 PM to 4:30 PM

Rachel Upjohn Building Auditorium
This talk will be recorded and live-streamed via Zoom.

This faculty candidate is presented by the Eisenberg Family Depression Center in partnership with the Michigan Medicine Department of Psychiatry.

The advancement of precision psychiatry in treating depressive symptoms provides substantial optimism for

David Zald, Ph.D.

improving treatment outcomes beyond the current status quo. The success of precision psychiatry requires attention to the larger dimensional structure of psychopathology, the expansion of predictive biomarkers, and a mechanistic targeting of specific symptoms or symptom clusters.

The first half of this talk explores how data from novel phenotypic and neuroimaging approaches can inform precision psychiatry of affective disorders. Building on past work on the neural underpinnings of motivation, the second half of the talk examines the potential to capitalize on recent neuropharmacological advances to mechanistically target specific symptoms involving motivational deficits and anergia.

David Zald, Ph.D.

Henry Rutgers Professor of Psychiatry
director of the Center for Advanced Human Brain Imaging (CAHBIR)

David Zald, Ph.D. is the inaugural director of the Center for Advanced Human Brain Imaging (CAHBIR), and Henry Rutgers Professor of Psychiatry. His research uses a combination of MRI and PET imaging to examine the links between individual differences in brain structure and function and the risk for, and expression of, psychopathology. With over a quarter century of experience in performing neuroimaging research, he joined the Rutgers faculty in 2020 with express purpose of developing the Center for Advanced Human Brain Imaging.