Wednesday, February 7, 2024

Why Do We Sleep? The Circadian and Homeostatic Control of Sleep and Wake

4:00 PM to 5:00 PM

Forum Hall
Palmer Commons

Held as part of the Department of Computational Medicine and BioInformatics's (DCMB) Seminar Series and featuring MNI Executive Director Ravi Allada, M.D.

Ravi Allada, M.D.

Why we sleep remains one of the most enduring mysteries in science. Sleep is homeostatically regulated, where the duration of wakefulness drives subsequent sleep. Here, we aim to determine how the waking experience is sensed to trigger sleep and how sleep restores the brain. How does the circadian clock interact with the sleep homeostat? How does impaired sleep lead to human diseases such as Alzheimer’s disease? Our work makes widespread use of -omics approaches, including identifying diagnostic biomarkers in human sleep disruption.