Ravi Allada, M.D.
Why we sleep remains one of the most enduring mysteries in science. Sleep is homeostatically regulated, where the duration of wakefulness drives subsequent sleep. Here, we aim to determine how the waking experience is sensed to trigger sleep and how sleep restores the brain. How does the circadian clock interact with the sleep homeostat? How does impaired sleep lead to human diseases such as Alzheimer’s disease? Our work makes widespread use of -omics approaches, including identifying diagnostic biomarkers in human sleep disruption.