Abstract: Gene expression is regulated by multiple factors including genetic variation, sex, and cell type. I will describe differences by sex in human skeletal muscle cell type composition, cell type-level gene expression and chromatin accessibility, and bulk miRNA expression in 287 people. I will describe regulation of subcutaneous adipose gene expression by genetic variants in a meta-analysis of >2,200 people. These studies help to better understand transcription and post-transcriptional regulation of gene expression by sex and genetic regulation of gene expression.
About Dr. Scott's research: Dr. Scott uses a combination of bulk and single nucleus omic data - RNA expression, chromatin accessibility, metabolites and DNA methylation - to understand the cellular genetic regulatory landscape and to infer biological connections between genetic variation and disease risk.
Read more about Dr. Scott's research in this 2020 Center for RNA Biomedicine "featured researcher" article.
