Akira Ono, PhD
Professor of Microbiology and Immunology
[email protected]

Available to mentor

Akira Ono, PhD
Professor
  • About
  • Links
  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    My lab is interested in the relationships between virus life cycle and cellular structures. In particular, our research focuses on roles played by cellular membranes during replication and spread of retroviruses (e.g., HIV-1) and orthomyxoviruses (e.g., influenza A virus).

    Links
    • Ono Lab
    Qualifications
    • visiting fellow
      National Institute of Allergy and Infectious Diseases, Laboratory of Molecular Microbiology, 2000
    • postdoctoral fellow
      National Institute of Health (Japan), Japan, 1996
    • PhD
      University of Tokyo, Tokyo, 1994
    • MS
      University of Tokyo, Tokyo, 1991
    • BS
      Waseda University, Tokyo, 1989
    Research Overview

    My lab is interested in the relationships between virus life cycle and cellular structures. In particular, our research focuses on roles played by cellular membranes during replication and spread of retroviruses (e.g., HIV-1) and orthomyxoviruses (e.g., influenza A virus). Current major areas of research in my laboratory are:
    i) molecular mechanisms that determine the sites of virus assembly,
    ii) relationships among virus assembly, plasma membrane microdomains, and cortical actin cytoskeletons,
    iii) roles played by cell polarity and virus morphology in virus spread,
    iv) incorporation of host plasma membrane proteins into nascent virus particles and their effects on virus spread, and
    v) roles played by macropinocytosis in virus entry.

    Recent Publications See All Publications
    • Presentation
      Seminar "The molecular mechanisms that determine the site of HIV-1 particle assembly and the efficiency of virus spread" (scheduled)
      2024 Apr 19;
    • Presentation
      Seminar "The molecular mechanisms that determine the site of HIV-1 particle assembly and the efficiency of virus spread" (scheduled)
      2024 Apr 3;
    • Journal Article
      The "basics" of HIV-1 assembly.
      Sumner C, Ono A. PLoS Pathog, 2024 Feb; 20 (2): e1011937 DOI:10.1371/journal.ppat.1011937
      PMID: 38300900
    • Presentation
      Invited Talk, "The roles Gag plays in HIV-1 particle assembly and subsequent steps"
      2023 Dec 1;
    • Presentation
      Seminar "The molecular mechanisms that determine the site of HIV-1 particle assembly and the efficiency of virus spread"
      2023 Nov 30;
    • Presentation
      Invited Talk, "HIV-1 Gag interaction with tRNA via MA-HBR"
      2023 Sep 1;
    • Journal Article
      The role of tunneling nanotubes during early stages of HIV infection and reactivation: implications in HIV cure.
      Valdebenito S, Ono A, Rong L, Eugenin EA. NeuroImmune Pharm Ther, 2023 Jun; 2 (2): 169 - 186. DOI:10.1515/nipt-2022-0015
      PMID: 37476291
    • Presentation
      Workshop Talk, "MA highly basic region-dependent binding of selenocysteine-TCA tRNA to HIV-1 Gag in cells"
      2023 Jun 1;
    Featured News & Stories
    Department News
    Meet Vicky Wang, an undergraduate student in Dr. Akira Ono’s lab
    Meet Vicky Wang, an undergraduate student in Dr. Akira Ono’s lab