Available to mentor
My lab is interested in the relationships between virus life cycle and cellular structures. In particular, our research focuses on roles played by cellular membranes during replication and spread of retroviruses (e.g., HIV-1) and orthomyxoviruses (e.g., influenza A virus).
Ono Lab
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visiting fellowNational Institute of Allergy and Infectious Diseases, Laboratory of Molecular Microbiology, 2000
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postdoctoral fellowNational Institute of Health (Japan), Japan, 1996
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PhDUniversity of Tokyo, Tokyo, 1994
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MSUniversity of Tokyo, Tokyo, 1991
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BSWaseda University, Tokyo, 1989
My lab is interested in the relationships between virus life cycle and cellular structures. In particular, our research focuses on roles played by cellular membranes during replication and spread of retroviruses (e.g., HIV-1) and orthomyxoviruses (e.g., influenza A virus). Current major areas of research in my laboratory are:
i) molecular mechanisms that determine the sites of virus assembly,
ii) relationships among virus assembly, plasma membrane microdomains, and cortical actin cytoskeletons,
iii) roles played by cell polarity and virus morphology in virus spread,
iv) incorporation of host plasma membrane proteins into nascent virus particles and their effects on virus spread, and
v) roles played by macropinocytosis in virus entry.
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2024 Apr 19;PresentationSeminar "The molecular mechanisms that determine the site of HIV-1 particle assembly and the efficiency of virus spread" (scheduled)
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2024 Apr 3;PresentationSeminar "The molecular mechanisms that determine the site of HIV-1 particle assembly and the efficiency of virus spread" (scheduled)
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Sumner C, Ono A. PLoS Pathog, 2024 Feb; 20 (2): e1011937Journal ArticleThe "basics" of HIV-1 assembly.
DOI:10.1371/journal.ppat.1011937 PMID: 38300900 -
2023 Dec 1;PresentationInvited Talk, "The roles Gag plays in HIV-1 particle assembly and subsequent steps"
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2023 Nov 30;PresentationSeminar "The molecular mechanisms that determine the site of HIV-1 particle assembly and the efficiency of virus spread"
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2023 Sep 1;PresentationInvited Talk, "HIV-1 Gag interaction with tRNA via MA-HBR"
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Valdebenito S, Ono A, Rong L, Eugenin EA. NeuroImmune Pharm Ther, 2023 Jun; 2 (2): 169 - 186.Journal ArticleThe role of tunneling nanotubes during early stages of HIV infection and reactivation: implications in HIV cure.
DOI:10.1515/nipt-2022-0015 PMID: 37476291 -
2023 Jun 1;PresentationWorkshop Talk, "MA highly basic region-dependent binding of selenocysteine-TCA tRNA to HIV-1 Gag in cells"