Available to mentor
Andrew W. Tai, MD, PhD is an Associate Professor in the Department of Internal Medicine and in the Department of Microbiology & Immunology. Dr. Tai obtained his bachelor's degree in biochemistry from Harvard University, followed by a combined MD-PhD training program at the Weill Medical College of Cornell University. Following a residency in internal medicine at the Brigham and Women's Hospital in Boston, he completed a clinical and research fellowship in gastroenterology and hepatology at the Massachusetts General Hospital.
Dr. Tai joined the faculty at the University of Michigan in 2009. His research work focuses on the molecular mechanisms by which cells support RNA virus infection, such as by hepatitis C virus, dengue and Zika viruses, and SARS-CoV-2. He has been awarded a Research Scholar Award by the American Gastroenterological Association and is an elected member of the American Society for Clinical Investigation (ASCI). He also co-directs the preclinical curriculum at the University of Michigan Medical School and has been recognized by several awards for his teaching.
In his spare time, he enjoys running, cycling, soccer, and downhill skiing.
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FellowMassachusetts General Hospital, Gastroenterology, 2009
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Research FellowMassachusetts General Hospital, Gastroenterology, 2009
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ResidentBrigham and Women's Hospital, Internal Medicine, 2005
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InternBrigham and Women's Hospital, Internal Medicine, 2003
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MDWeill Medical College, Cornell University, 1300 York Avenue, 2002
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PhDWeill Graduate School of Medical Sciences, Cornell University, 1300 York Ave, 2001
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ABHarvard University, Cambridge, 1994
Specialty
Gastroenterology, Internal Medicine
Area of practice
Liver disease, including viral hepatitis B and hepatitis C, cirrhosis, nonalcoholic fatty liver disease; liver cancer including hepatocellular carcinoma
All viruses are parasites in that they need to infect a cell in order to replicate and produce more viruses. During viral infection, viruses hijack many cellular proteins and cellular functions. My laboratory seeks to discover these cellular proteins and to understand how they are exploited during viral infection, as they may represent targets for antiviral therapies. We focus on a large class of viruses called “positive-strand RNA viruses” that includes many medically important viruses such as hepatitis C virus, dengue virus, Zika virus, and SARS-CoV-2 (the virus that causes COVID-19).
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Zhang J, Kennedy A, de Melo Jorge DM, Xing L, Reid W, Bui S, Joppich J, Rose M, Ercan S, Tang Q, Tai AW, Wang Y. 2024 Mar 15;PreprintSARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion.
DOI:10.1101/2022.03.04.483074 PMID: 35291301 -
Bragazzi Cunha J, Leix K, Sherman EJ, Mirabelli C, Frum T, Zhang CJ, Kennedy AA, Lauring AS, Tai AW, Sexton JZ, Spence JR, Wobus CE, Emmer BT. J Virol, 2023 Dec 21; 97 (12): e0127623Journal ArticleType I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection.
DOI:10.1128/jvi.01276-23 PMID: 37975674 -
Tai AW, Sewell JL. Gastroenterology, 2023 Sep; 165 (3): 529 - 533.Journal ArticleHow to Effectively Engage With Preclinical Medical Learners.
DOI:10.1053/j.gastro.2023.05.014 PMID: 37209950 -
Williams JM, Chen Y-J, Cho WJ, Tai AW, Tsai B. J Cell Biol, 2023 Jul 3; 222 (7):Journal ArticleReticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication.
DOI:10.1083/jcb.202203060 PMID: 37093123 -
Xu C, Dobson HE, Yu M, Gong W, Sun X, Park KS, Kennedy A, Zhou X, Xu J, Xu Y, Tai AW, Lei YL, Moon JJ. J Control Release, 2023 May; 357: 84 - 93.Journal ArticleSTING agonist-loaded mesoporous manganese-silica nanoparticles for vaccine applications.
DOI:10.1016/j.jconrel.2023.03.036 PMID: 36948420 -
Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu S-L, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou J-H, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. mSphere, 2023 Apr 20; 8 (2): e0003423Journal ArticleVirology under the Microscope-a Call for Rational Discourse.
DOI:10.1128/msphere.00034-23 PMID: 36700653 -
Hoffstadt J, Wotring J, Porter S, Halligan B, O’Meara M, Tai A, Sexton J. 2023 bioRxiv,PreprintHigh-Content Screening to Identify Inhibitors of Dengue Virus Replication
DOI:10.1101/2023.03.24.534108 -
Cunha JB, Leix K, Sherman EJ, Mirabelli C, Kennedy AA, Lauring AS, Tai AW, Wobus CE, Emmer BT. 2023 Mar 1;PreprintType I interferon signaling induces a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection.
DOI:10.1101/2023.02.28.530557 PMID: 36909579
